Conserved Protein Domain Family
WASH_WAHD

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pfam11945: WASH_WAHD 
WAHD domain of WASH complex
This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see pfam04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.
Statistics
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PSSM-Id: 463408
Aligned: 9 rows
Threshold Bit Score: 319.019
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDV98214                       11 AYQVSIIPTDLQHEETIIRAAQSLDCLNKTINSIFGRIDARLARNGVHVQLINERVLRAQAKINALVGSKKSIKIYAPAR 90 
XP_002113304                    5 KFAVPIITTDLRREESLRQTADVLQHVEKVCNDTFDHVVQRVEDVKKKLEAIENRTKVAKAKIDKIRTSTKATTILSANK 84 
WGS:AAGF:cds.TTHERM_00766470A  10 hNKITMSNTDMSQYEGLEKTLSNLSMLDETLSYVIQRFDNQQNQYKNKIQQYLDRIHICQKKIAALQEQKKAITFVSP-- 87 
ETN65114                        3 TYSVPVIKHDMRHEETVLDAINALEYLNEVVNDVFGKINGRIERNRERLQALDARIEKAKDDVRRLHDAKEAIIIYSPSR 82 
B2RYF7                         14 VYAVPLIQPDLRREEAIQQVADALQYLQNISGDIFSRISQRVELSRRQLQAIGERVSLAQAKIEKIKGSKKAIKVFSSAK 93  Norway rat...
XP_025004586                   23 TYSVPLIQPDLRREEAVQQVADALQYLQKVSGDIFNRISQRVETSRAQLQAISERVTLAQAKIEKIKGSKKAIKVFSSAK 102
Q28DN4                         11 AYSLPLILPDLRREEAIHQITDTLQHLQTVSNDIFSRILQRVETNRGQLQRINGRLSLAQAKIERLKGIKKAIKVFSSAK 90  tropical clawed frog...
XP_006004518                   11 VYSVPLIQPDLRREEAIHQITDALQYLQRVSDDIFSRVLERVESNRTRLQGVSDRITIAQARIKKIKGSRKATKVFSSAK 90 
A4IG59                         14 VYSVPLIQPDLRREEAVHQITDALQYLEMISTDIFTRVSESVEKNRAHLQSVTDRIKLAQARVQKIKGSKKATKVFSSAK 93  zebrafish...
EDV98214                       91 FPGtSTLNINISATFpqvvdhqkptsmeTSTSSAAAVPAEFSQRRRHTNNL----------------------------- 141
XP_002113304                   85 YPV-ADIMTNYESLF-------------ASIDSELGELKRSHYRITNDIMPf---------------------------- 122
WGS:AAGF:cds.TTHERM_00766470A  88 ----SSFVQKYKFTHenkks---ilqdyKQKHNISKFETQFGYQLKNDPEQvgpiidnsrpddlyqilnisygkfksrek 160
ETN65114                       83 YPA-SDMEATVEPTF-------------TATNGIRM--PECSYRLKDKPYq----------------------------- 117
B2RYF7                         94 YPA-PEHLQEYNSVF--------------TGALDPGLQRRPRYRIQSKHRPl---------------------------- 130 Norway rat...
XP_025004586                  103 YPA-PERLQEYCSIF--------------AGAEDPAKQKWPRHKIQSKHRMl---------------------------- 139
Q28DN4                         91 YPA-PEHLQEYSSVF--------------AGAEDGWLAKKLRHKIQSKHRPl---------------------------- 127 tropical clawed frog...
XP_006004518                   91 YPA-PERLQEYSSIF--------------MGVEDAATLKRPRYKVQSKHRPl---------------------------- 127
A4IG59                         94 YPA-PEKLQDYSSIF--------------TGAVDPASQKRPRIKVQSKLRPl---------------------------- 130 zebrafish...
EDV98214                      142 ----NDALEEQPSgaeldtvFFHVRGE-EQLETPLVVERqqtnrmaGLGTLPE-TKSVPTLMRFNTNEfayaggqdgned 215
XP_002113304                  123 ---nEKLIDESPK-------IELPNARhRINMVEDQLDE-------GLGGLPTdLTSVSSLLLFNSQE------------ 173
WGS:AAGF:cds.TTHERM_00766470A 161 npveNRKLPLKEK-------FF------------------------GVGTYPKkIKCAESLLVLNTNI------------ 197
ETN65114                      118 ---pSHSLQEKIQ-------FYHVKTVrDGCERIFPFERstkahrlGNRE-RHqTAYLDELLLYGDGAy----------- 175
B2RYF7                        131 ---dERALQEKLK-------YFPVCVS-TKSEPEDEAEE-------GLGGLPSnISSISSLLLFNTTE------------ 180 Norway rat...
XP_025004586                  140 ---dEKSLQEKLK-------YFPVCVN-TKIHQEDDAEE-------GLGSLPRnISSLSSLLLFNTTE------------ 189
Q28DN4                        128 ---dEQAVQEKLK-------YFPVCVN-TRGQDEESAEE-------GLGSLPRnISSVSSLLLFNTTE------------ 177 tropical clawed frog...
XP_006004518                  128 ---eEKLLQEKLM-------YFPVYLN-TKHQEENEGEE-------GLGSLPRnVRSVSSLLLFNTNE------------ 177
A4IG59                        131 ---dDKAQQEKLM-------YLPVCVN-TKKRSEDETEE-------GLGSLPRnVNSVSSLLLFNTTE------------ 180 zebrafish...
EDV98214                      216 lNAWKR--TLPPQRSSHKRATPAVAARsSALLAPAPHSLSHGTIKLATPAGDLRYTPAALAAPAIDVPLDLP---DLPGI 290
XP_002113304                  174 -NPYKKyiTLDPLAGAVTKTRSTIEQE-ANALGDAPVTISQRQGMERKPMESYFYVPNLGDVPEFDVPSFLP---NLSGV 248
WGS:AAGF:cds.TTHERM_00766470A 198 -NPYRKyqQIDNLIIDESKQQQRVKPDdTNQINLQVAPVGISNQLTAYQRSELTYVP---ETKKVDNAVSIPldfGLDGV 273
ETN65114                      176 vREYKG---QDWKRSTLRKGSVHGNVIrEERIMSTSSPMIRSKV--KKKTQDLFYTPSLSDAPKLDVPIDLP---DLPGI 247
B2RYF7                        181 -NLYKKyvFLDPLAGAVTKTHTMLGTE-EEKLFDAPLSISKREQLEQPAPENYFYVPGLGQVPEIDVPSYLP---DLPGV 255 Norway rat...
XP_025004586                  190 -NLYKKyvFLDPLAGAVTKTHVALETEtEEKLFDAPLSITERGQLDRQVAENYFYVPDLGQVPEIDVPSYLP---DLPGI 265
Q28DN4                        178 -NLYKKyvFLDPLAGVVTRTNPALEGEdEEKLFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPYSLP---DLPGV 253 tropical clawed frog...
XP_006004518                  178 -NLYKKyvLLDPLAGAVTKTHNTLETEkEEKPFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPSYLP---DLPGI 253
A4IG59                        181 -NLYKKyvFLDPLAGAVTKTHTTLETEkEDKPFDAPLSITKREQLERQTAENYFYVPDLGQVPEIDVPSYLP---DLPGI 256 zebrafish...
EDV98214                      291 ANDLQYEpVEEQTPIAPSHQFVd-LPDLPGLNEN-EPEPQPEDEK 333
XP_002113304                  249 ADDVTFD-VDNEISIAPSAGFV--FPDLPTVETT-PVPTANGGTE 289
WGS:AAGF:cds.TTHERM_00766470A 274 AEDFDID-YGGQDLIQPSAWLIq-NPTLPDPYAN--AQPSSQSQN 314
ETN65114                      248 VSNINY--VGSNTLIAPSLQLAgiIEQLPSLEDL-TSAIDVADHH 289
B2RYF7                        256 ADDLMYS-ADLGPGIAPSAPGA--IPELPAFHTE-VAEPFQPERE 296 Norway rat
XP_025004586                  266 AADLMYS-ADLGPGIAPSAPSSa-IPELPTFSTE-SVEPSQADLQ 307
Q28DN4                        254 ADDLMYS-ADLGPGIAPSAPGVp-IPELPTFITEdITENSRTDSQ 296 tropical clawed frog
XP_006004518                  254 AADLMYS-ADLGPGIAPSVPGSn-MPELPTFYTE-PTYVNGQDQQ 295
A4IG59                        257 ADDLMYS-ADLGPGFAPSVPASnsIPELPSFGTD-HDESSGSDSQ 299 zebrafish
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