Conserved Protein Domain Family
bHLH_TS_TAL2
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cd19707: bHLH_TS_TAL2 
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 (TAL-2) and similar proteins
TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. It has been implicated in T-cell acute lymphoblastic leukemia.
Links
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Statistics
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PSSM-Id: 381550
Aligned: 7 rows
Threshold Bit Score: 123.947
Created: 2-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens SCL (2YPA):E47bHLH heterodimer binds DNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   # ### #    #                 # ##                      
Q16559         2 TRKIFTNTRERWRQQNVNSAFAKLRKLIPTHPPDKKLSKNETLRLAMRYINFLVKVLGEQS 62  human
OCU00965       2 TRKIFTNTRERWRQQNVNSAFAELRKLIPTHPPDKKLSKNETLRLAMKYINFLIDILGDQE 62  African clawed frog
KFQ93151       2 TRKIFTNTRERWRQQNVNSAFAKLRKLIPTHPPDKKLSKNETLRLAMKYINFLVKVLGEPG 62  crested ibis
XP_006009202   2 TRKIFTNTRERWRQQNVNSAFAELRKLIPTHPPDKKLSKNEILRMAMKYINFLMKVLGEQG 62  coelacanth
XP_007890745   2 TRKVFTNTRERWRQQNVNSAFAELRKLVPTHPPDKKLSKNEILRLAMKYIDFLVKLLKDQG 62  elephant shark
AAH93124       2 TRKVFTNTRERWRQHNVNTAFAELRKLIPTHPPEKKLSKNEILRLAMRYINFLVTLLESQG 62  zebrafish
ADB22661      48 TRRMFTNTRERWRQQNNNIAFAELRKLIPTHPPDKKLSKNEILRSAMRYIDFLVKLRDDQD 108 Saccoglossus kowalevskii

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