1WMZ,1WMY


Conserved Protein Domain Family
CLECT_CEL-1_like
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cd03589: CLECT_CEL-1_like 
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C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina
CLECT_CEL-1_like: C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. The CEL-1 CTLD binds three calcium ions and has a high specificity for N-acteylgalactosamine (GalNAc). CEL-1 exhibits strong cytotoxicity which is inhibited by GalNAc. This protein may play a role as a toxin defending against predation. Echinoidin is found in the coelomic fluid of the sea urchin and is specific for GalBeta1-3GalNAc. Echinoidin has a cell adhesive activity towards human cancer cells which is not mediated through the CTLD. Both CEL-1 and Echinoidin are multimeric proteins comprised of multiple dimers linked by disulfide bonds.
Links
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Statistics
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PSSM-Id: 153059
Aligned: 13 rows
Threshold Bit Score: 186.024
Created: 23-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:carbohydrate binding [chemical binding site]
Evidence:
  • Structure:1WMZ_D, Cucumaria echinata C-type lectin Cel-I bound with N-acetyl-D-galactosamine.(GalNAc), contacts at 3.5 A.
  • Comment:Two hydroxyl groups of GalNAc, in addition to forming hydrogen bonds with side chains of various CEl-1 residues, coordinate with the calcium ion designated CA2.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1WMZ_D      3 CPTDWEAEGDHCYRFFnt-lTTWENAHHECVs-YSCstln--------vrsDLVSVHSAAEQAYVFnywrgi-------- 64  Cucumaria echinata
1WMY_A      3 CPTDWEAEGDHCYRFFnt-lTTWENAHHECVs-YSCstln--------vrsDLVSVHSAAEQAYVFnywrgi-------- 64  Cucumaria echinata
P06027      3 CPTFWTSFGSNCYRFFav-sLTWAEGEQFCQs-FSVpsrgd-----idsigHLVSIHSETEQNFVYhyfetst------- 68  Anthocidaris crass...
AAC28441  111 CPTYWVHFQGSCYRYFgd-rVTWEVARESCKdhYSIsg-----------qaELASIHSQQENSFAYdlflsaagg----- 173 Heliocidaris eryth...
BAB78598   31 CPPMWTFYNGNCYRYFgt-gKTYDEAESHCQe-FTEvg-----------lgHLASIASAEENNLLLtmwksv-------- 89  Asterina pectinifera
AAM70488   33 CPTFWTGYGNYCYRYFnd-vKTWLEAEFYCRt-FGAggcmg-----qtgqaHLVSIHSQDENDFLFsyfdtvrnkl---- 101 purple urchin
AAR02404   31 CPKLWTGFRNHCYRFFsh-eLTWLAAENFCRs-FTVpslgewgevtrtnsgHLVSIHSQPEQDFVTalyessr------- 101 purple urchin
XP_698678  44 CPLFWTEFEGYCYRFFpl-nRTWAEADLYCAe-FSNghk----------saKLTSVHSWEENVFVYdlvnsr-------- 103 zebrafish
XP_781582  11 CPEFWNLFGGNCYRYQgd-rLTWSAAEARCNeaFTSag-----------vgHLASIHSLAENRFVYemfkssvsindipd 78  purple urchin
XP_785723  28 CPQFWLLFNGNCYRYFge-rVTWEEARNRCRdhYSLng-----------raDLVSIHSEQENAFVYdlfrssasit---- 91  purple urchin
XP_787997  34 CSPLWTAYNGYCYRFFndrnISWIDAELRCRs-FSIpcgdst---ssqtiaHLVSVHSQEEMDFLTamyeslr------- 102 purple urchin
XP_791383  26 CPHAWTQRNGYCYRYFdd-mLPWSVAESRCHehFDSdg-----------iaHLVSIHDQAENDFIFdifnsangdhgdl- 92  purple urchin
XP_536957  89 CPLFWMEFKGHCYRFFpl-nKTWAEADFYCSe-FSIgrk----------saKLASIHSWEENVFVYdlvnsc-------- 148 dog

Feature 1                                                   # #          #     #             #
1WMZ_D     65 -------dsqagQLWIGLYDky--nEGDFIWTDGSk-vGYTKWAGGQPDNwn-----naEDYGQFRhte------ggAWN 123 Cucumaria echinata
1WMY_A     65 -------dsqagQLWIGLYDky--nEGDFIWTDGSk-vGYTKWAGGQPDNwn-----naEDYGQFRhte------ggAWN 123 Cucumaria echinata
P06027     69 ------kddttpEMWLGFNDrt--tEGNFQWTDGSp-nDFTAWVGSNPDNyg-----sgEDCTQMVmga------glNWI 128 Anthocidaris crass...
AAC28441  174 ---sslaghtyyGAWIGFFQptassTGPFQWSDGTsasDFDSWLPRQPDNag-----nnEGCTHFWrrnag-ddtlqSWN 244 Heliocidaris eryth...
BAB78598   90 ------rttttgGLWIGLNDqa--eEGNFIWTDGSa-vTFTDWATTQPDNyq------nEDCAHMRheld----gddRWN 150 Asterina pectinifera
AAM70488  102 --ppaigpirdeRLWLGLTDkk--qEGFWTWSDGTn-lDYANWRAGEPNNng-----gnEDYAQMSvein----hegLWF 167 purple urchin
AAR02404  102 -----kkgdenaGHWFGLHDts--tDGTFEWTDGTp-vDFTHWKPGQPDNypnh--vgnENCGVMRshs------gsQWK 165 purple urchin
XP_698678 104 ------mpgiptDIWIGLHDrr--qEGTMEWTDGSp-fEYSYWDGNQPDDgihr-ipeeEDCVEIWyrqn---salrSWN 170 zebrafish
XP_781582  79 wvynredrnpiyGIWIGLHQtv--aDGPWKNSDDTdqgDFYKWRPVEPNNsyyq-geqvEDCVHIWrtgse-sddqqTWN 154 purple urchin
XP_785723  92 ---pdlsapptyGVWIGAYQttkgsTGPFIWSDGSg-lDFEQWMIGQPSNwk-----gnEDCAHLWrrdae-ddilqSWN 161 purple urchin
XP_787997 103 ------pkrgpsRAWIGLHDra--sENCSEWIDGTt-vNFTDWGTGQPNDrn-----gfHDCTFFArwg------dyKWN 162 purple urchin
XP_791383  93 ditntpgtdlptGMWTGLHQev--rDGPWVWSDGSs-nDYTHWLPGQPDNgyhargrlnEDCVIIWrnddngsestrQWD 169 purple urchin
XP_536957 149 ------vpgipaDIWTGLHDhr--qEGQFEWTDGSs-yDYSYWDGSQPDDgvha-dpeeEDCVQIWyrps---salrSWN 215 dog

Feature 1     #                  
1WMZ_D    124 DNSAa-----AQAKYMCKL 137 Cucumaria echinata
1WMY_A    124 DNSAa-----AQAKYMCKL 137 Cucumaria echinata
P06027    129 DLPCs----sTRHYLICKL 143 Anthocidaris crassispina
AAC28441  245 DAPCt-----LDFPYICKV 258 Heliocidaris erythrogramma
BAB78598  151 DIACs-----RAFAYVCKM 164 Asterina pectinifera
AAM70488  168 DMTDah--gdYIVHYICKM 184 purple urchin
AAR02404  166 DGRCvqpsdsAIHYFICKT 184 purple urchin
XP_698678 171 DNNCd-----KAFPFVCKI 184 zebrafish
XP_781582 155 DMYCn-----EVMSFVCKM 168 purple urchin
XP_785723 162 DMPCg-----NDQPFICKV 175 purple urchin
XP_787997 163 DMGCdp---dNVESYICKH 178 purple urchin
XP_791383 170 DIGCdi---qGGMPYVCKM 185 purple urchin
XP_536957 216 DNTCn-----HKFPFVCKI 229 dog

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