4A8J,4EJS


Conserved Protein Domain Family
Elp5
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cd19496: Elp5 
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Elongator subcomplex subunit Elp5
Elongator is a highly conserved multiprotein complex involved in RNA polymerase II-mediated transcriptional elongation and many other processes, including cytoskeleton organization, exocytosis, and tRNA modification. It is composed of two subcomplexes, Elp1-3 and Elp4-6. Elp4-6 forms a heterohexameric RecA-like ring structure, although they lack the key sequence signatures of ATPases.
Links
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Statistics
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PSSM-Id: 410904
Aligned: 37 rows
Threshold Bit Score: 41.0768
Created: 16-Jul-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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hexamer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:hexamer interface [polypeptide binding site]
Evidence:
  • Structure:4A8J; Saccharomyces cerevisiae Elongator subcomplex Elp456 hexamer interface, contacts at 4A
  • Structure:4AJ
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #   # #                                        ###                        
4A8J_B         25 ILCLDSIa-qTSYKLIQEFVHQSkskg----------------neyPIVYISFETVnkp---------------syCTQF 72   Saccharomyces...
AAM10496       19 VLLRDSVe-wEGRSLLKALVKKSalc------------------geQVHILGCEVSeeefregfd--sdinnrlvyHDFF 77   human
NP_001073536   15 ILIQDSVq-cCGRGILRCCINAAlkr------------------deDVHVLGFESPetevcag------ldssfaqKLHF 69   zebrafish
CCF48395      902 VILQDSLv-qSSTPLIRELIARSaqr------------------nhPVLLVSTLRRpetyld---------giaagRVAT 953  Ustilago hordei
NP_001242822   22 LTIKDSLaspFAFHVFSHILLQLsshvia-----------qksqsqGIVIVALSRSpssytsllkmngmdvassnkWIHI 90   soybean
ABK94526       22 LTIKDTAaspFGFHVFSHVLSQLssfila-----------sksqsrGIVIVAFSRSpsfyvdllksrgidvnsshkWVQI 90   black cottonwood
XP_002601152   15 VIIEDCVe-hDGRPVFHCFCSELsmr------------------cdSVHLFHLENPaegfla---------ganvsKTHS 66   Florida lancelet
XP_643146      30 ILLEDSLe-sSSQHLLNHLYSLWlptis--------------kqhrNIWFLNFSSTiseykql------skkynncNFIV 88   Dictyostelium...
EFX79461       14 ILIQDSCs-lKGRPLFLSLIRHYsen------------------gySIRYFKYDSPlssettem-----eqlkiswKKSI 69   common water ...
EFA74587       16 LLLEDSLd-sSSQHLLNHLYDYWlrpinsnqstatssglqvpnlkkNVWFINQSQPlseyikl------skkynniNFIV 88   Polysphondyli...

Feature 1          #                                                                              
4A8J_B         73 IDAtq---------------------------------xdFVHLVKQIISYlpaata----------------tqakkHX 103  Saccharomyces...
AAM10496       78 RDPlnwskte-----------------------eafpggpLGALRAMCKRTdp-----------------------vpVT 111  human
NP_001073536   70 HKGfpdplgw-----------------------rgkssftVQQFTSQHITQlirds-----------------qpakaSV 109  zebrafish
CCF48395      954 IDAttlanaydp-------------------daikstielTERIKTQLSSLnas---------------------ttkST 993  Ustilago hordei
NP_001242822   91 LDCytdplgwkdk-----------------arksanvtdpSQQISLATSSYktvkdvdklflviaelgrgligenkarFC 153  soybean
ABK94526       91 LDCytdplcwkdqlmgs----------gnfmdashetsssLSRVCKDVKDLdklysmilelg------kglvgqgkdrFS 154  black cottonwood
XP_002601152   67 HDGfsdpllweeqnrds----------sldridltsppdfLEHIKKTPSQAs-------------------------tVA 111  Florida lancelet
XP_643146      89 IDYysdsfgwnnnnnnnsnnnnitenlqqipmifksvkhdSASIIKDIQNVyncvpn----------------kfkenPI 152  Dictyostelium...
EFX79461       70 VDGnq----------------------------------dVMSVKNSWTSEarn----------------------dqVL 93   common water ...
EFA74587       89 IDCysdpfgwnisnnnsn--------snegpivfncskqdSQSIIETVKSVfnsnsvs--------------sklkesPV 146  Polysphondyli...

Feature 1                                 #                                                       
4A8J_B        104 VIIDSLNyis----------teyITRFLSEIAsp---------------------------------------------- 127  Saccharomyces...
AAM10496      112 IALDSLSwlllr------lpcttLCQVLHAVShqdsrpgd---------------------------------------- 145  human
NP_001073536  110 LVVDSLSlvlrh------hdpviVCQSLQELRkgg--------------------------------------------- 138  zebrafish
CCF48395      994 VIIDSLNlvshvqqngvagtsklVGEALSFIGasgkfivglq-------------------------------------- 1035 Ustilago hordei
NP_001242822  154 VAIDSLSellrh------asmqsVAGLLSNLRshd--------------------------------------------- 182  soybean
ABK94526      155 VAIDTINemlrh------tstptVAGLLSNLRshe--------------------------------------------- 183  black cottonwood
XP_002601152  112 VVIDSLTpflqk------ypgyvICRALQRLLrarles------------------------------------------ 143  Florida lancelet
XP_643146     153 ILINSIStlilk------sglsdTCNLIRSLTnynfnkvkqdkekqekeqkeqqdnnnnnnkkkiekinkietgiegsvs 226  Dictyostelium...
EFX79461       94 VAIDSLSpllln------wtvgaIASALRNLQktt--------------------------------------------- 122  common water ...
EFA74587      147 LVINTISslvlk------nglsdTCNLIRSLInfsnvnnnnsnssgsnnsssnkqstls-----stmnriqtgiqggvqq 215  Polysphondyli...

Feature 1                         # ##                   ##  #        
4A8J_B        128 --------hcTXVATYHKDIkdenrtvipdwnnnypDKLTLLQFXATTIVDI 171  Saccharomyces cerevisiae S288c
AAM10496      146 ---sssvgkvSVLGLLHEELhg-------------pSPVGALNSLAQTEVTL 181  human
NP_001073536  139 -------vvkTIIGLLHSDLhl-------------qGIVGIVCHLASTVISV 170  zebrafish
CCF48395     1036 mggvetstcaALISALHSPLiw-------------rSSSLTSAAAGGAGGTV 1074 Ustilago hordei
NP_001242822  183 -------qisSMFGLLHSDLhe-------------eRAVAVLEYMSSMVASV 214  soybean
ABK94526      184 -------qisSIFWLLHSDLhe-------------iKVTSALEYLSSVVASV 215  black cottonwood
XP_002601152  144 ----dgtevsQVVAGFHGDLhd-------------nSTAAALRHMATTWVQL 178  Florida lancelet
XP_643146     227 nrikmeksfsCIFAILHTDLhey-----------eqSVQKQLQYISSVSIQV 267  Dictyostelium discoideum AX4
EFX79461      123 --------tvSVIALVHGDVhd-------------kHTLQALNYIFPCHLAV 153  common water flea
EFA74587      216 ratksersftCLLGILHNDLhys-----------dtSVTKQLEYISSTSIQV 256  Polysphondylium pallidum PN500

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