3WXQ,1BWY


Conserved Protein Domain Family
FABP3
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cd19466: FABP3 
fatty acid binding protein 3
FABP3 (also known as heart-type fatty acid binding protein, H-FABP, MDGI, O-FABP) is a cytosolic protein mainly expressed in cardiac and skeletal muscle cells. In these tissues, it plays an important role in fatty acid transportation, cell growth, cell signaling, and gene transcription. This subgroup belongs to the intracellular fatty-acid binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Links
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Statistics
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PSSM-Id: 381241
Aligned: 6 rows
Threshold Bit Score: 222.824
Created: 13-May-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 37 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:ligand is bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on FABP3 and other cytosolic fatty-acid binding protein family members with structure
  • Structure:3WXQ; Homo sapiens FABP3 with bound stearic acid, contacts 4A
  • Citation:PMID 7683727
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #           #  ##  # #   ##  #  # # # #      # # # # ## # # #       ##### #    
3WXQ_A         4 AFLGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDILTLKTHSTFKNTEISFKLGVEFDETTADDRKVKS 83  human
1BWY_A         3 AFVGTWKLVDSKNFDDYMKSLGVGFATRQVGNMTKPTTIIEVNGDTVIIKTQSTFKNTEISFKLGVEFDETTADDRKVKS 82  cow
NP_001026060   4 AFVGTWKLVDTANFDEYMKALGVGFATRQMAGLTKPTTIIEVDGDKATVKTHSTFKNTEISFKLDEEFDETTADDRHVKS 83  chicken
O13008         4 AFAGTWNLKDSKNFDEYMKALGVGFATRQVGGMTKPTTIIEVAGDTVTLKTQSTFKNTEISFKLGAEFDETTADDRKVKS 83  rainbow trout
NP_001079923   3 KFAGTWRLVDSKNFDEYMKALGVGFATRQIGNVTKPTTIISVDGDKIVLQTQSTFKNTEVSFKLNEEFDEITADDRKCKS 82  African clawed ...
NP_694493      4 AFIGTWNLKESKNFDEYMKGIGVGFATRQVANMTKPTTIISKEGDVFTLKTVSTFKSTEINFKLGEEFDETTADDRKVKS 83  zebrafish

Feature 1                # #          # #      # # #        # #  
3WXQ_A        84 IVTLDGGKLVHLQKWDGQETTLVRELIDGKLILTLTHGTAVCTRTYEK 131 human
1BWY_A        83 IVTLDGGKLVHVQKWNGQETSLVREMVDGKLILTLTHGTAVCTRTYEK 130 cow
NP_001026060  84 LVKLDGGKLVHVQKWDGKETSLVRELKDGKLILTLTMGNVVSTRTYEK 131 chicken
O13008        84 LITIDGGKMVHVQKWDGKETTLVREVSGNALELTLTLGDVVSTRSYVK 131 rainbow trout
NP_001079923  83 LVTLEDGKLKHVQKWDGKETILIREVDGDKLVLNLTFGDVASSRHYER 130 African clawed frog
NP_694493     84 VITLDGGKLLHVQKWDGKETTLLREVSDNNLTLTLTLGDIVSTRHYVK 131 zebrafish

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