Conserved Protein Domain Family
CYCLIN_CNTD2

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cd20542: CYCLIN_CNTD2 
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins
CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410245
Aligned: 9 rows
Threshold Bit Score: 133.986
Created: 15-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9H8S5       108 RALVVDWLVQVHEYLGLaGDTLYLAVHLLDSYLsagrv-rlhrLQLLGVACLFVACKMEEcvlPEPAFLCLLSAdsfsra 186 human
KYO26573       2 RALVVDWLVQVQECLGLaDDTLHLAVQLLDAYGqagpv-rartLQLLGLACLFLACKMEEthcPTPATLCFMTEdmfsht 80  American alligator
OCT67997     131 RTVLVDWLVQVHEYLGLeEETLYLAVYLMNSYMkvhki-htalLQLLAASCLFLASKIEEsliPEPAELCFMMEdafskk 209 African clawed ...
XP_006821854 192 RAILMDWLVKVQCHLELlDQTLFLAMNLIDKFIsvskt-tldkLQLVGITCLLIASKLEErypPEIAVLCYLTDhtyskn 270 Saccoglossus ko...
PAA53888     129 RGVINDWLLQVQVHERCsTDSLHLGVALADHAClrlpf-serlYQLVASVCFFIACKVVErfpPKVSKLVYLTDnaytnk 207 Macrostomum lig...
EKC19463     259 RSILTDWFIQVQVHQELsQQTLHLTVELVDRFLtyqri-plntFQLVGITCLLIAAKYHErfaPEVQTLCYLTDntydkn 337 Pacific oyster
XP_013407692 186 REILVDWLLQVEVHLEIqSQTIHMAIAMLDIFTsrrsi-gldrYQLLGITCLFIAAKFEErfpPEIDTLTHLTDgsytkd 264 Lingula anatina
NP_001038424 164 RAILVDWLIQVHEVFQFsEETLYLTVHLLNRALrlikv-sisgLQLLGVVCLFLAAKREEcllPEVSELCYLMEnayskk 242 zebrafish
CCD74644     212 RATLCDWMIRVQQYLKLrTESLHLAVSLVDQYTwrqitlypseYQLLGVTAIFIAVKFVErfpPATKILCYLTEdsynsk 291 Schistosoma man...
Q9H8S5       187 ELLRAERRILSRLDFRL 203 human
KYO26573      81 ALLRMERRVLRRLRFRL 97  American alligator
OCT67997     210 ELLKMERKILSRLKFEL 226 African clawed frog
XP_006821854 271 MVLRMEIIVLRKIRFGL 287 Saccoglossus kowalevskii
PAA53888     208 EFLRMELSVLEALEFRL 224 Macrostomum lignano
EKC19463     338 QVLKMERQILRTIGFDL 354 Pacific oyster
XP_013407692 265 QVLKMEILVLKVLRFSL 281 Lingula anatina
NP_001038424 243 QLLRMERRVLIGLKFDL 259 zebrafish
CCD74644     292 QVLDFEFKMLEALNFDI 308 Schistosoma mansoni
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