6VJA


Conserved Protein Domain Family
CD20

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pfam04103: CD20 
CD20-like family
This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.
Statistics
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PSSM-Id: 461174
Aligned: 38 rows
Threshold Bit Score: 46.101
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6VJA_C        15 LGAV---QIMNGLFHIALG--GLLMIPAGIyapiCVTVWYPLWGGIMYIISGSLL-AATEKNSR----KCLVKGKMIMNS 84 
Q3TRE0        29 LALL---QLALGIAVTVLG--FLMASISPS----LLVRDTPFWAGIIVCVVAYLG-LFMLCVSYq--vDERTCVQFSMKV 96  house mouse
Q1LVQ8        43 VALL---QLLLGIAVAAVA--FLMLAISSS----LLARETPHWAGIIMCVVSLLG-FVLFCITRvpdeR--ALLQFVIKL 110 zebrafish
EDO41456      21 FGVV---QVILGLSLTGLS--FAAFALSESd---RIRNACPYWAGFTVFFSGGVG-IVAWRHST----ILSMGLFTFFSA 87 
Q5HZJ5        37 LGLA---QVLLGILVITFS--MVASSVTTTe---SIKRSCPSWAGFSLAFSGLVG-IVSWKRPF----TLVISFFSLLSV 103 house mouse
Q9GYM6        46 LANV---HVFLGIIMIVLSglADYASTRINt---IRLHGLEEICSFYFVLVGLVG-ICGSASYR----RGLVITYLVMCI 114 Caenorhabditis ...
EDO34181       8 LGIIssfHLVFGVFSVVLG--IVTFKVAPYf---YGVFGMGIWLGAWMLITGVAGlLTASVPTN----MCRLGSFIGCSL 78 
Q5BLA7        17 LGIL---QVACAGLCVVCG--FMDAVFRKSt--tLSETRAPLWAGLIMAAPGVLA-LFASQKKN----PYLVNVMIVSSV 84  zebrafish
XP_012819541  17 LGIL---QIACAGISIVSG--FMDGAFRREs--tLGRTRAPLWAGLIMTIPGVLA-LFSSQKKN----PVLVNALIAASV 84 
Q925D4        61 LGVT---QILLGLVSCVLG--VCLYFGPWTe---LCASGCAFWSGSVAILAGVGI-VIHEMGQG----KLSGHISRLLLL 127 Norway rat
6VJA_C        85 LSLFAAISGMILSIMDILNIKISHFLKMESLNfira--htpyINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLI 162
Q3TRE0        97 FYFLLSALGLMVCMLAVAFAAHHYSLLAQFTC----------ETSLDSCQCKLPSSEPLSRAFVYRDVTDCTSVTGTFKL 166 house mouse
Q1LVQ8       111 LYFFLCTMGLVMSVVVIAFQCYHYTLTNSFSC----------REMREDCICTLDPEDPIARMFVFSAVSDCSDITSTLPM 180 zebrafish
EDO41456      88 VCVVLHMIGTILTGEVGGLLKSVLECQFSEVDqsc-----icCDSIMTCKQSVPSYKFEGVDDCDILTGLLKELMYGLCV 162
Q5HZJ5       104 LCVMLSMAGSVLSCKNAQLARDFRECSMEGKVcvc----cppIPLHRPCPEWGQELKVALNSTCDEARGALKNLLFSVCG 179 house mouse
Q9GYM6       115 HSIFIFVPAIITVSSFDIHFYQHECWGECDWHlla-----tsFPSNSKCQIMCGDHVDDAMRRRMTRLGTDYRLDAGLIA 189 Caenorhabditis ...
EDO34181      79 VGLVTLFVCAIIIGLGVLQHFKFESSINREYY-----------IAKGPNYHKEYSRPQEHFDERNQNGENGVGIYGTLLA 147
Q5BLA7        85 VSLFAVVIVFVYACVTLSYGEEDDEI-------------------------FHAHPVPEVRFVLSRM---VKGANCTLLV 136 zebrafish
XP_012819541  85 FSCFTTLIVIVYASLTLGYGEDDDDI------------------------FSSPPHVIHARFILGKL---VQGANIAMLI 137
Q925D4       128 ACSATAAAATVMGVKSLIWQTSASYYFEISSTcdslqpsivdRFRSVRFTDDSDWRTERCREYLRMMMNLFLAFCILFTV 207 Norway rat
6VJA_C       163 FAFFQELVIAGIVENE 178
Q3TRE0       167 FLIIQMVLNLVCGLVC 182 house mouse
Q1LVQ8       181 YYLLQVLLNLAQAIVC 196 zebrafish
EDO41456     163 LNIFGSLVCFIATILG 178
Q5HZJ5       180 LTICAAIICTLSAIVC 195 house mouse
Q9GYM6       190 AAILEFLLSIATCVVA 205 Caenorhabditis elegans
EDO34181     148 LIVMDVIVNLVTMAVC 163
Q5BLA7       137 ACTGSLLFSSLIAYIG 152 zebrafish
XP_012819541 138 ASVSSLCVALCIAYMG 153
Q925D4       208 ICILKIVVSVASLGLS 223 Norway rat
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