Conserved Protein Domain Family
GT4_ALG2-like
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cd03805: GT4_ALG2-like 
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins
This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.
Links
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Statistics
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PSSM-Id: 340834
Aligned: 29 rows
Threshold Bit Score: 511.749
Created: 6-Dec-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #                                                                  
P43636         7 RTIAFIHPDLGIGGAERLVVDAALGLq----QQGHSVIIYTSHCDKSHCFEEVKNgqLKVEVYGDFLPTNFLGrFFIVFA 82  baker's yeast
XP_001307724   4 KKIAVLHPDLGIGGAERLIIDVAHAVm----IDHKDTTVYTTHYDTNHCFPDTKD--LTIKVAAAWVPRSIFGfGHIIFS 77  Trichomonas vag...
AAX79041      60 LKVVFLHPDLGIGGAERLVVDAAIALqryqkVTPVQVIIVTNHHDPQRAFAETVDgtVTVQVFGSWLPASIKGrAKVFAA 139 Trypanosoma brucei
CAJ07955      80 LRVAFLHPDLGIGGAERLIIDAAVGLqkrqsIRLVEVIIVTSHHDRSRAFKETTDgtVRIVVRGSALPASIFGhAKVLCA 159 Leishmania major
AAH77444       3 PSVLFVHPDLGIGGAERLVVDAALALk----SRGCHVQVWTSHYDPNHCFSETRNsgIPIRCCGDWLPRSLLGrCHALCA 78  African clawed ...
AAH49444      22 VRVVFLHPDLGIGGAERLVVDAAVALr----SRGCSVQIWTAHYDPQHCFSETLSpdLPVVCVGDWLPTSVFGyFHALCA 97  zebrafish
XP_001450661   8 LKIAFLHPDLGIGGAEQLVVNLALALq----KNHYVKIYTPHHDPNHSFPETNGQ--IPVEVRGNIIPAHFFGyCTAMCA 81  Paramecium tetr...
XP_001017562   8 LRIGFIHPDLGIGGAEQLIVNMAVALk----KQGHNVIIYTPYHDPKHCFQATIDgtIPVEVRGAIVPQTIFGkLWALCA 83  Tetrahymena the...
XP_794663      2 VRVIFLHPDLGIGGAERLVVDAALALq----TRRHSVKIYTAHHDPTHCFKETSDgtLEVVTAGDWLPRNIFGsCYALCA 77  purple urchin
NP_495010      2 VRVTILHPDLGIGGAERLIVDAAVGLq----DRGHSVRIFTNQYSRSHCFQETLD--LDICTVVPWIPRSIFGkGHALCA 75  nematode

Feature 1                                                                                        
P43636        83 TIRQLYLVIqlilqKKVNAYQLIIIDQLSTCIPLLHIFss-aTLMFYCHFPDQLLAq-------------rAGLLKKIYR 148 baker's yeast
XP_001307724  78 LFSFLWLTIy---aALTSKAEIFIVDQISAWVPILRLLcpraKIIFYCHFPDLRLAs-------------hKSLIRKIYR 141 Trichomonas vag...
AAX79041     140 TLRMCWAAWvt--cWMHPDADCFMVDQVAAVLPLLSFVapqiPRLFYCHFPDQCCDgnrden---qqykkkPSIFRLLYR 214 Trypanosoma brucei
CAJ07955     160 TIRMGFAAFat--cWSFPNTDCFVVDQVAAAMPALHLFagrtPILFYSHFPDRLCDpnrnpdgtfksagsgVAPWHAIYR 237 Leishmania major
AAH77444      79 YIRMIFLALyi-vfLSGEQFDVVFCDQVSACIPFFKLArnskKVLFYCHFPDQLLTq-------------rLSWIKRMYR 144 African clawed ...
AAH49444      98 YLRMIYLTIyl-vlFSGEEFDVVFCDQVSACIPFLRLArqrkKVLFYCHFPDQLLTq-------------rRSALKRLYR 163 zebrafish
XP_001450661  82 YIRMILATLyi--iFFSGRWDVIIIDQVSVCLPLLWLFr--rKTIFYCHFPDKLLCve------------rKSFIKKIYR 145 Paramecium tetr...
XP_001017562  84 TIRVIFCTLyl--iCFGFKFDVVIVDQVSPAVPLLRLFn--rKCLFYCHYPDKLLCve------------rRSILKKIYR 147 Tetrahymena the...
XP_794663     78 YIRMIYVALyl-llFSREPYDVIICDQISACIPFLKLGr--sKVLFYCHFPDLLLTk-------------rQSFLKKLYR 141 purple urchin
NP_495010     76 YLKMIIAALyi--vIYHKDTDVILSDSVSASQFVLRHFsk-aKLVFYCHFPDRLLTk-------------rDGNLKAFYR 139 nematode

Feature 1                                                                                        
P43636       149 lPFDLIEQfsVSAADTVVVNSNFTKntFHQTFKYLSNDpd----vIYPCVDLSTIeiedidk---------kffktvFNE 215 baker's yeast
XP_001307724 142 lPFDLIEKwgIKASHLIYVNSNFTAgvTKQEFGDIPVRv------LYPCVDTSRQve-------------------rKQS 196 Trichomonas vag...
AAX79041     215 kLFDEVEVfaMNYASSIVSNSKFSRaaTLKVFPKLSNRidaeadiFYPPVSLAVRegakpngdtkvfdteeldklrdAIQ 294 Trypanosoma brucei
CAJ07955     238 gFFDQVEAssMKFATSIVCNSKFSRqvCIDTFPTLADKihettdiFYPPVETKVRevtedalsk----saalrelkqAVS 313 Leishmania major
AAH77444     145 aPIDWLEEktTGMADCILVNSYFTAavFKKTFTSLAYIep---tvLYPSLNVSNFvstvfe----------dvsdlfPVK 211 African clawed ...
AAH49444     164 gPIDWFEEltTGMADRILVNSQFTAkvFKQTFPKLSEIht---dvLYPSLNSSAFddeveg-----------lggllPEG 229 zebrafish
XP_001450661 146 fFLDSFEEisMLFANLVLVNSQFTReiVKQAFPLYNKYgrq-pevLYPAIEFSKFemapel-----------nrldsRLE 213 Paramecium tetr...
XP_001017562 148 fFLDYIEEfsLLFANKILVNSNFTRevYQRSFKYLSKYnnp--eiLYPAIDFSSFddtik------------qsapvDSK 213 Tetrahymena the...
XP_794663    142 tPIDWLEEktTGMSDCIVVNSNFTAdtFKQTFTTLKDVqp---dvLYPSLNFSAFnarvep-----------agdliPVG 207 purple urchin
NP_495010    140 nIIDWIEEytTGLADVICVNSNFTKnvVRETFKSLASQel---tvLYPSLNTEFFdsieasd---------dfgeeiPRG 207 nematode

Feature 1               ###                                                                      
P43636       216 GDRFYLSINRFEKKKDVALAIKAFALSEdqi-------ndnVKLVICGGYDERVAENVEYLKELQSLadeyelshttiyy 288 baker's yeast
XP_001307724 197 PTPLFVSLNRYERKKDHNLAIKALAKAItki--------pdAKLVIAGGYDDRVTENVEHYKELRELaekl--------- 259 Trichomonas vag...
AAX79041     295 GRSVVLSINRYERKKNLVLAIEAFARLLnsgkt---tcsgaPLLVLAGGYDTRLEENVAHLNELQKVadty--------- 362 Trypanosoma brucei
CAJ07955     314 SAVTFVSINRYERKKNIELAIEAFALLLstgefknaeskkpLMLIIAGGYDPRLAENVQYADELAALatak--------- 384 Leishmania major
AAH77444     212 RQHIFLSINRFERKKNLNLALESMFELRkrlsl---lewerVHLVLAGGYDERVLENVEHYQELKDNaak---------- 278 African clawed ...
AAH49444     230 RSFIYLSINRYERKKNLPLALQALANLKdrlsv---gewecVHLVMAGGYDERVVENVEHYEELRSLvts---------- 296 zebrafish
XP_001450661 214 SNNYFLSLNRYERKKNIALAIHAFAAFRqqlnsd--eniesVRLVIAGGFEQRVEENAQHFEELNQIaqr---------- 281 Paramecium tetr...
XP_001017562 214 ASPFFLSLNRYERKKNINLAIQAFAQFVkesa-----snnqFKLIIAGGYDERIAENVEHHKELLSLake---------- 278 Tetrahymena the...
XP_794663    208 VKTLFLSINRYERKKNLVLAIEAMGELKsrlse---dewqnVHLVMAGGYDGRVTENLEHYEELVQRade---------- 274 purple urchin
NP_495010    208 TKYVFTSLNRFERKKNIVLALDAFEKLKsnlpa---defsqCHLVIAGGYDLKNPENIEHYDELVEHmkkl--------- 275 nematode

Feature 1                                     #                     #                            
P43636       289 qeikrvsdlesfktnNSKIIFLTSISSSLKELLLERTEMLLYTPAYEHFGIVPLEAMKlGKPVLAVNNGGPLETIKsyva 368 baker's yeast
XP_001307724 260 ------------eltEKQVELQRSISDQQKWDLIASATAMIYTPQNEHFGIVPIEAENaGCPVIACNTGGPLETCNv--- 324 Trichomonas vag...
AAX79041     363 ------------klmDSQILFLKNITELEKRYLLSQCCCLLYTPTSEHFGIVPTEAMIsAKPVVAVNRGGPCESVGe--- 427 Trypanosoma brucei
CAJ07955     385 -----------lripASQVRCLKNISDDEKAVLLSEMRALVYTPSREHFGIVPVEAMAySKPVVAIADGGPCESVGsvel 453 Leishmania major
AAH77444     279 ------------ydiCNHVTFLRSFSDEQKRNLLHRAICVLYTPSNEHFGIVPIEAMYmHCPVVAVNSGGPLESVEnn-- 344 African clawed ...
AAH49444     297 ------------lglEDHVTFLRSFSDKQKLSLLHNSTCVLYTPSNEHFGIVPIESMYlRCPVIAVNSGGPLESVAhe-- 362 zebrafish
XP_001450661 282 ------------qnvAEYVSFKKNISDSERTQLMSNALAVLYTPEREHFGIVPVEAMYnQVPVIACNSGGPKESIQng-- 347 Paramecium tetr...
XP_001017562 279 ------------lnvEDKVVFKFSISNKERTQLLQTAQAVLYTPENEHFGIVPVECMYmKRPVLACNSGGPKESVVdg-- 344 Tetrahymena the...
XP_794663    275 ------------lklTDHVTFIRSFSDAQKLTLLDSCTCLLYTPSNEHFGIVPIEAMYmYRPVIAVNSGGPLETIAhk-- 340 purple urchin
NP_495010    276 ------------elpADQIVFLHSPSDTQKVNLIRRSRAVLYTPDREHFGIVPVEAMYlGTPVIAVNTGGPCESVRnn-- 341 nematode

Feature 1                                                                         
P43636       369 genessaTGWLKPAVPIQWaTAIDESRKIlqngSVNFERNGPLRV-------KKYFSREAMTQSF 426 baker's yeast
XP_001307724 325 ------eGCFICEPTVDAFaDAMVEAASMk--sHDKELRENAERFg------FKAFAKQLHDDIL 375 Trichomonas vaginalis G3
AAX79041     428 -------GGTLCDPTPEAFaEAILLYLNDde-lRRRVGEAGRKRA-------SDVFTIERFGEKL 477 Trypanosoma brucei
CAJ07955     454 e-dpskcGGLLSSPEPAAFaEKMACFARDpv-yAAKVGAQGRARV-------LERFSTEAFSTQL 509 Leishmania major
AAH77444     345 ------vTGFLCSPNPKEFaDAMEKFVKNpd-lKNRMGESGHLRV-------KNKFSTEAFSDEI 395 African clawed frog
AAH49444     363 ------eTGFLCEPTPERFsEAMQNFVSDpk-lKQRMGQAGRERV-------QQRFSMQAFAEQL 413 zebrafish
XP_001450661 348 ------vTGYLCESKTNEW-QQREKQRNGrk-rERTSYSIVWIRIisnangqLCKDGYQNRKIKI 404 Paramecium tetraurelia
XP_001017562 345 ------eTGFLLQSNPSDWsKKMDWIAKNps-kAAEMGQNGRKRA-------IEKFGLEAFAESI 395 Tetrahymena thermophila SB210
XP_794663    341 ------qTGFLCEPSAASFaPALERFVREpd-lKNRLGKAGRDRV-------INNFSFRAFGNKL 391 purple urchin
NP_495010    342 ------eTGFLVDQTAEAFaEKMIDLMKDee-mYRRMSEEGPKWV-------QKVFAFEAFARKL 392 nematode

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