6M49


Conserved Protein Domain Family
INSIG

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pfam07281: INSIG 
Insulin-induced protein (INSIG)
This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations.
Statistics
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PSSM-Id: 462131
Aligned: 74 rows
Threshold Bit Score: 88.8343
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6M49_A        30 IRGVVLFFIGVFLALVLNLLQIQRNVtlfpp-----dviasIFSSAWWVP-------PCCGTASAVIGLLYPSIDR---- 93 
XP_002172038 118 LGVIIVMFLGWSFTYLAEKLLLEARLpg-----------lrFTVHSQQYKph---wsLLFGFAAILVGFSFPYADRls-- 181
XP_013025325 102 FKFLAIFGLGAIFTYMAEGIVQEAKLsl-----------ltVRYGNWVFKpn---wsVTFGLVAIGLAVSYRLMDVryp- 166
Q9Y7R5        95 CKLCVIFGLGFVFTYLAEQIVQDAKLpl-----------ltVNLKSWKFEpp---wpAIFGFVAVILGLSYRRMDTkyp- 159 Schizosaccharom...
EMR08866     109 LKFICLYIWGRVITIFVFHAQMKENI---------------TSPYKFEILthiphfrTLYSLGMALFGFLTPVIDSlmyk 173
EDV22141       5 LRTLIVFVVGVLLSLALLILQIERNValfppg-----vlsdlSSIPWWVP-------ISCGAGAATIGLSLPKMDEwf-- 70 
XP_002416085  10 WRVAFLFLVGVFFSLMLDFFQIQYRLsafern----ligsmFMSSPWWVP-------AICGTAAVSVGLLYPCVDHk--- 75 
EDO42464      14 VRGVVLFLIGGFLAMMLFVLsvlpeaqkrrwgsfpmeilakVYSTFWWIP-------PSCGTLAAFVGLICPCLDT---- 82 
CDS40446       5 FRSFILFVIGVLFYYIFGLIqgfrsgif------ndkfsqcLLSTSFGIP-------LCCGLLSVACGLTSPRLYH---- 67 
EDV27174      16 RIVIALFFIGVIFALVLNVLQVQRNVaafsrdvlsglalfgLSMSTWWML-------PSYGTGAVLIGLAFPCADH---- 84 
6M49_A        94 -----------HLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIA 162
XP_002172038 182 ----------hNGHRLVARPFEWNLIVRSIMALSFVLIGLKRCLGTDVKQTAIGFAVNALSVWFIFDHTKTGFVMSSFFS 251
XP_013025325 167 ---------sgSSGTKTSNSSQFQVFSRYLAAFATLLLTMKRLLSTQSTHSFAALIASAITIWYVFDRSKNGFTVSCVMS 237
Q9Y7R5       160 ---------lgAAPLRPSQSSKWQWISRYLAAFATLLLSMKKLLFISNSHSIVALVASSASIWYIFDRSRNGIILSTITS 230 Schizosaccharom...
EMR08866     174 fgftqasknayQIEIPNSKYIEIFEIMRVFSTFTGIVYAFVKLSWVLDVKASLFLFFIGFSMWFIFDRAQTGFFLSSITS 253
EDV22141      71 ----------qRKYDYHHDQVEWVGVLRCVGIFVGITYASTLAYNSVIAKFSVSLSLMAIGQWWLFDRSVSGFVLGVAVS 140
XP_002416085  76 -------------lGEETIPHRWSDVMKCIALFVGINQASAKIELQSDWQPSLSLVLLSVSLWWLCDRTHSGFGLSILTA 142
EDO42464      83 -----------KLGKPHNFQREWSSVARCVTMFVGISHAIAKLNFHSSHQLFLFVACTSFLLWWLFDRSQNGFSVAVLSA 151
CDS40446      68 -----------NLKIPNAYEPEWSSIMRCVIFFMGISHASAKLDIISISQLLLTSFCFAIGIWWIFDRSVSGILTGFLMS 136
EDV27174      85 -----------HLGESPKIKNEWTSIMRCTALWIGINHAAATLNFSTPAQLTFWVSAMSLCLWWLYDRTRTGLFLAMLSA 153
6M49_A       163 FLATVVtqLLVy------------nGVYQytsPDF-LYVRSWLPCIFFAGGITMGNIGRQLA 211
XP_002172038 252 SLGTFL--YTAfvevnl---sqgesIHIS-------KSLRYWLPSIIFFACTVIGNVGR-LV 300
XP_013025325 238 IVGSIT--YYVfvdsapfslfetnpPEYQ---------FRYWIPMILFSASTIVGNAGRLLF 288
Q9Y7R5       231 VLGSIL--YYNlvdtskielngvefPEIQ---------FRLWIPMILFSASTIVGNAGRLLF 281 Schizosaccharomyces pombe 972h-
EMR08866     254 IIFTIIlsFTSdif---------knEDLM---RKEiFGIRSWILGFFFSSCITASNIGRRLF 303
EDV22141     141 FTATAVtqIIVhygif-----sfskPDFL--------SIRSWLPGVFFSATIAIGSLGRQLA 189
XP_002416085 143 LIATLVahFLVyyrig-----rcsdKDLT--------FVRSWLPCVFFSGGITVGNIGRLLA 191
EDO42464     152 LAAAIVvyMLAylgvy------------------ryrrIIAVVPGLFFAGAVTFSNIGRQLA 195
CDS40446     137 LLGTGIclVLGdqti------rsidPLLT-----------SWLPCIFFSGGITTSLVGRQLA 181
EDV27174     154 VVATGFnqILVsngvf-----synePDLL--------SVKSWLPSIYFSGGLTIGNIGRQLV 202
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