Conserved Protein Domain Family
FH_FOXR
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cd20036: FH_FOXR 
Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily
The FOXR subfamily includes two winged helix transcription factors, FOXR1-2. FOXR1, also called Forkhead box protein N5 (FOXN5), is required for proper cell division and survival possibly via the p21 and mTOR pathways. FOXR2, also called Forkhead box protein N6 (FOXN6), is an important player in a wide range of cellular processes such as proliferation, migration, differentiation, and apoptosis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410810
Aligned: 12 rows
Threshold Bit Score: 138.212
Created: 17-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                 ##  #                  ## ##  #      #             ### 
Q6PIV2       171 WSRPPLNYFHLIALALRNSspcGLNVQQIYSFTRKHFPFFRTAPEGWKNTVRHNLCFRdSFEKVPvsmqggastrPRSCL 250 human
Q28H65       174 WPRPPLNYCNLISLALRNSedgSLNVQQIYSFVREHFPFFRIAPDGWKNTVRHNLCFSsSFEKSSgwvc--adghRRSCL 251 tropical clawed...
Q6PJQ5       190 WQRPPLNCSHLIALALRNNphcGLSVQEIYNFTRQHFPFFWTAPDGWKSTIHYNLCFLdSFEKVPdslkdednarPRSCL 269 human
XP_014350393 212 WPRPPINYCILIALALKNSkndSLNVQQIYNFTREHFPFFQTAPDGWKNTIRHNLCFSnSFEKTShfvs--sgrnRKSCL 289 coelacanth
NP_001096594 202 WPRPPVNYCILIAMALSSSrsgSLNVQQIYNFTREHFPFFLTAPDGWKNTIRHNLCFSnSFKKTPqqvs--gdgkRKSCL 279 zebrafish
EMP33399     404 WPRPPLNYCILITLALRNSaegSLTVQQIYQFTRQHFPFFQTAPDGWKNTIRHNLCFSsSFEKTThfvc--negnRKSRL 481 Green sea turtle
PDM70513     335 NRELRWSFPNMVGFALLNSetgELPVADIYSFIVKHFPSYQTAPQGWKNSVRHALSKSgVFHKNEtivd--grmeRRRCL 412 Pristionchus pa...
XP_024504013  41 NPKTSLSFPQLVGLILINTttkALAVSEIYDIVSDIFPCYNDSSSTWKNSIRHNLSTKdWFEKIPqrqs--dtrlRQSCI 118 Strongyloides r...
XP_024505141 185 FIKPPCSYPCLIAIALNNAvtnRLNVSELYEFIQYYFPFFQRAPEGWKNSVRHNLSTNgWFNKVDegrs--gyagRRSFL 262 Strongyloides r...
XP_024510509 461 FEKPQLPYAAFVTLILNNLntyAISVSEVYDGIIFLFPHFETAYEGWRNSIRHNLSMSrLYEKVEakvq---igsRKACM 537 Strongyloides r...
VDD85884     117 VRKPTLSFVCLIGLAFRNSkeeCLAVKDVYDFIETVFPFYRTASVGWRSSVRHNLSFSnFFLKVAteka---agkTRGYI 193 human pinworm
PDM70252      72 LPKPDWSIPNMVALALTNHg-pQLAVAEIYDFICFAFPFYRTAPDNWKNSVRHTLSHGdAFEKIIlddd---ysgRSKCL 147 Pristionchus pa...

Feature 1        #        
Q6PIV2       251 WKLTEEGHR 259 human
Q28H65       252 WKLTRQGRR 260 tropical clawed frog
Q6PJQ5       270 WKLTKEGHR 278 human
XP_014350393 290 WRLTPEGRR 298 coelacanth
NP_001096594 280 WHLTLDGRQ 288 zebrafish
EMP33399     482 WKLTLEGCR 490 Green sea turtle
PDM70513     413 WSIQQEKTN 421 Pristionchus pacificus
XP_024504013 119 WGFKSLTCI 127 Strongyloides ratti
XP_024505141 263 WGFTNPGVK 271 Strongyloides ratti
XP_024510509 538 WSMVKRDEP 546 Strongyloides ratti
VDD85884     194 WRINPEREL 202 human pinworm
PDM70252     148 WRIRPEQLW 156 Pristionchus pacificus

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