Conserved Protein Domain Family
SLC6sbd_GAT1
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cd11506: SLC6sbd_GAT1 
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain
GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
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Statistics
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PSSM-Id: 212075
Aligned: 4 rows
Threshold Bit Score: 1221.37
Created: 18-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on site-directed mutagenesis of rat brain GAT-1
  • Citation:PMID 8995422
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
P30531         2 ATNGSKVADGQISTEVseapvaNDKPKTLVVKVQKKAadlpDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGA 81  human
NP_001089153   2 ATNGTKVADGQISTELseapiiNDKPKTLVVKVQKKKtedmERDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGA 81  African clawed ...
XP_414303      2 ATNGTKVADGQISTEVdas-itNDKPKTLVVKVQKKKtdlpDRDTWKGKFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGA 80  chicken
NP_001007363   2 ATNGTKASDGHVLTEVneaptaNDKPKTLVVKVQKKKel-pDRETWQGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGA 80  zebrafish

Feature 1                                                                                        
P30531        82 FLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPW 161 human
NP_001089153  82 FLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAILSFWLNIYYIVIIAWAIYYLFSSFTTTLPW 161 African clawed ...
XP_414303     81 FLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPW 160 chicken
NP_001007363  81 FLIPYFLTLIFAGVPLFFLETALGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIAWAIYYLYNSFTTDLPW 160 zebrafish

Feature 1                      #                                                                 
P30531       162 KQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVY 241 human
NP_001089153 162 KNCDNYWNTERCFSNYSIPNTTNMTSAVLEFWERNMHQMTDGLEKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVY 241 African clawed ...
XP_414303    161 KHCENPWNTDRCFSNYTLANTTNMTSAVVEFWERNMHQMTDGLEKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVY 240 chicken
NP_001007363 161 KSCDNPWNTDKCFSNYSMANIGNMTSAVVEFWERNMHQLTDGLEKPGEIRLPLAITLAIAWVLVYFCIWKGVGWTGKVVY 240 zebrafish

Feature 1                                                                                        
P30531       242 FSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSI 321 human
NP_001089153 242 FSATYPYIMLVILFFRGVTLPGALDGILFYITPKFSKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNRFHNNVYRDSI 321 African clawed ...
XP_414303    241 FSATYPYVMLLILFFRGVTLPGAKEGILFYITPNFSKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNPFHNNVYRDSI 320 chicken
NP_001007363 241 FSATYPYFMLFILFIRGVTLPGAKEGILFYVTPEFSKLKESEVWLDAATQIFFSYGLGLGSLIALGSYNPFNNNVYKDSI 320 zebrafish

Feature 1                                                                                        
P30531       322 IVCCINSCTSMFAGFVIFSIVGFMAHvtKRSIADVAASGPGLAFLAYPEAVTQLPiSPLWAILFFSMLLMLGIDSQFCTV 401 human
NP_001089153 322 IVCCINSCTSMFAGLVIFSIVGFMAHvtKRPIEQVAASGPGLAFLAYSEAVTQLPiSPLWSVLFFSMLLMLGIDSQFCTV 401 African clawed ...
XP_414303    321 IVCCINSCTSMFAGFVIFSIVGFMANvtKRPIADVAASGPGLAFLAYPEAVTQLPiSPLWAILFFSMLLMLGIDSQFCTV 400 chicken
NP_001007363 321 IVCCINSFTSMFAGFVIFSIVGFMAHitKRPIADVAASGPGLAFLAYPEAVTQLPiSPLWAVLFFSMLLMLGIDSQFCTV 400 zebrafish

Feature 1                                                                                        
P30531       402 EGFITALVDEYPrlLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFY 481 human
NP_001089153 402 EGFITALVDEFPklLRTRREIFIAVVCVVSYLVGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECISISWCYGVNRFY 481 African clawed ...
XP_414303    401 EGFITALVDEFPklLRNRREIFIAVVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECISISWCYGVNRFY 480 chicken
NP_001007363 401 EGFITALVDEFPraLRGRREIFIAVVCLVSYLIGLSNITQGGLYVFKLFDYYSASGMCLLFLVFFECVSISWFYGVNKFY 480 zebrafish

Feature 1                                                                                        
P30531       482 DNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKG 561 human
NP_001089153 482 DNIEEMVGYRPCLWWKLCWTFFTPIIVAGVFLFSAIQMTPLTMGSYVFPSWGQGVGWFMALSSMVLIPGYMVYLFLSLKG 561 African clawed ...
XP_414303    481 DNIQEMVGYRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGSYVFPKWGQGVGWFMALSSMVLIPGYMAYMFLTLKG 560 chicken
NP_001007363 481 GNLEEMIGYKPCIWWKLCWVVFTPLIVAGVFLFSAVQMVPLTLNNYVFPKWGQGVGWCMALSSMVLIPGYMGYMFLTLKG 560 zebrafish

Feature 1                                                
P30531       562 SLKQRIQVMVQPSedi-vrpENGPEQPqags-stsKEAYI 599 human
NP_001089153 562 SLKQRLQLMIRPTdev-vcsENGPEQLsqsn-sanKEAYI 599 African clawed frog
XP_414303    561 SLKQRIQVMIQPSedi-shpENGPDQAqqsn-sanKEAYI 598 chicken
NP_001007363 561 SYKERLRIMIQPTaaavrtqENGPEQQpenptpanDEAYI 600 zebrafish

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