6W1S


Conserved Protein Domain Family
Med24_N

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pfam11277: Med24_N 
Mediator complex subunit 24 N-terminal
This subunit of the Mediator complex appears to be conserved only from insects to humans. It is essential for correct retinal development in fish. Subunit composition of the mediator contributes to the control of differentiation in the vertebrate CNS as there are divergent functions of the mediator subunits Crsp34/Med27, Trap100/Med24, and Crsp150/Med14.
Statistics
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PSSM-Id: 463254
Aligned: 11 rows
Threshold Bit Score: 1198.36
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W1S_S          1 VNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSCSSVLTAIS 80   house mouse
EEC12065        7 SSIKSLLLQAWRERWTDVRWGINIKNVLPRGVSGDVYDLADCILQEALVGPGPNNLFLSYLTHCLSAQVVSYGAVLSSIG 86  
2_pfamImport    1 --LKHLIITAWKERWTEKKWSIHVKKLITS--SSDMFHLADVLVSQSFIGSSPNLLMLGYISYALDCGMLSYASVISAIS 76  
XP_018673004    6 adLKHLVITSWKERWSEKKWSIHVKKLMTS--PSDMLHVSDVLVSQSFIGSSPNALLLRYISYALECGLLSYASVITAVS 83  
Q2PW47          4 VNLKQAILQAWKERWSDYQWAINIKKNCPKGATWDYLNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAIS 83   zebrafish
OCA45933        4 VNLKQAILQAWKERWSDYQWAINMKKFFPKGVTWDILNLAEALLDQAMIGPAPNPLILSYLKYAINSQMVSYSTVLTAIS 83  
Q7Q6D9         13 TLLKLMLLRAWKERWTDCQWGINVKTILTRGVSGDVYNLADAIIQQAVVGSGANMLFLSYLKHSLCAHLISHAAVLNRIA 92   African malar...
1_pfamImport    4 SSLKALLLRAWRERWSDLQWGIHIKTILPRGVSGDVYNLADCILQQALVGPAPNQLVLSYLKHSLSSQLVSYASVLQRIA 83  
Q9VSF2          6 KILQ-LIYVAWRERWTDSQWGINIKKVLPRGVSGDVYNLADCLMQQALIGSTANPLVLNYLKHSLCAHLVSHAAVIRCIA 84   fruit fly
Q16X15         13 TLLKLMLLRAWKERWTDCQWGINVKAVLTRGVSGDVYNLADCILQQAVVGSGANTLFLSYLKHSLCAHLISHAAVLKRIS 92   yellow fever ...
EFN62777       81 SSLKALLLRAWRERWTDLQWGINIKTILPRGVSGDVHNLADCILQQALVGPGPNQLVLSYLKHSLSSQLVSYAAVLQRIS 160 
6W1S_S         81 KFDDFSRDLCVQALLDIMDMFCDRLSCHGK-AEECIgLCRALLSALHWLLRCTAASAERLQEGLEagtpAPGEKQL-ALC 158  house mouse
EEC12065       87 RFQSFFKPPCILSLLQLLYSIQAKVTCHGN-EEECIaLCKAIVSVTHWLYMCMCHSISKIVELKQ----STEHGLIlEKA 161 
2_pfamImport   77 KHEELSKIESTKGVYNLLQQCLQ-FVCNNKvTEDAMeLCFSLRIVLQWLLRNIEQYLKGVRDIYG-----SAAEELiKLN 150 
XP_018673004   84 KHEDLSKIESTKAVYGLLKDCLQ-VVCKTRlMEDAMeLCFSLRMVLKWLLQNIEQCLKRVWDMYG-----STAEEIiKLN 157 
Q2PW47         84 KFDDFSRELCVKSLLEIMDMFSNRLSCHGK-AEECIgLCRAMLCTVVWLLQGCAWYCERLRDPNDf---SALESSL-RAC 158  zebrafish
OCA45933       84 KFDDFSRDLCIQALLEIMDMFCDNLSCHGK-AEECIgLCRALMSALNWLLRCSTFYTDKLKDMLDp---VAGENHL-SMC 158 
Q7Q6D9         93 KYDQYDKHHCLIALLDFLKSIIDGVTCRGK-QEEAI-LTKATVSLVHWLLQIYECVLQSYAEDSTl---QPEEEEVvQRV 167  African malar...
1_pfamImport   84 KFDGFHKPHCISCLLEFIESIQSGITCRGK-PEEGI-LASAILNLVHWLLQCYQHAVSTNAEPTA---------DMiQKP 152 
Q9VSF2         85 KYDKLERVYCITALLEFLASIVDGVTCRIK-SEEAV-LPSSVVHLVYWLLQIFARTVQHYELYGEi---SAEQSYMlDQT 159  fruit fly
Q16X15         93 KYDHFEMHHCLIALLEFLESIIGGVTCRGK-QEEGL-LTKAMLSLVYWLMQIYEHAIETFSENRSl---TTEQQEVvEKT 167  yellow fever ...
EFN62777      161 KYDAFHKPHCILSLLEFLESIQVGITCRGK-PEEDL-LAAAVLSIVHWLLQCYLHALTKTPQNNSl---IPNSNEL-DKP 234 
6W1S_S        159 LQCLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNP-QLRSQAERCGTLIRSIPSMLSVHSEQL---- 233  house mouse
EEC12065      162 CETLCFFSESTFLKSLLYIGKHEDSAVYSQLVQKQQELESKLSQSQGFnISKDTLECALNLVRLVDDMPHISLSSCvsg- 240 
2_pfamImport  151 CQTLELIATQPRTAGLLTIARFAESGIWNHIETDLAVIKNTSGQHPMYgEISTSCHHVSQLSK-----CSIAQKPVykl- 224 
XP_018673004  158 CDILKLIATKPRTSGLLIIARFAEGGVWSHIETDLAVIKNSSGQHPLHsEISASCHHVSQLSK-----CSISPKPVykl- 231 
Q2PW47        159 LERMANLLHSTKNRALVHIARLEEQASWTNVEQAVLKLTENLSAVTNP-TLKESLEECVSLVKSIPQMLCLQCDPP---- 233  zebrafish
OCA45933      159 LQRLESMLSSTKNRALIHIAKLEEPASWTSVEQSLLRLAESISLLPSV-QLRNQAEECVSLIRSIPSMLSVHSDQL---- 233 
Q7Q6D9        168 AVVLERIVENPFLLGVLSIGKCDDPELFIALQKRFNGISNLTLTTGYVaNVGAGNANSLTVTDCMRKLVLLEVDALemrp 247  African malar...
1_pfamImport  153 VSILHNMLNCDFLTAMLYLAKHDDIELYNEVVKKCQEIEELLTQHEHI-------ATAAPLHQTLTKICKLELGATsltn 225 
Q9VSF2        160 CVVIDRLSQQQFLLSMLYVGCHEELEICGRIRDKYATIKGSLTNSNFT-------LNAPQVEQQLQQLAFIEAKHLemqp 232  fruit fly
Q16X15        168 ANVLEKIVQSQFLLGVVFVGKFEDPELFGMLAKKCLEIENLTVKSGFVpPVVS--QKNVTVNDYIRKVASIETETLeike 245  yellow fever ...
EFN62777      235 ASILQQMLNSDFMCAMMYLAKYDDKDLYIDVAKKCQEIERFLKTSNQ--------KSAVPIEDSLKKLCNLEIESLsfe- 305 
6W1S_S        234 --------HKTGFPTIHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIEspEGTQELKWTAF 305  house mouse
EEC12065      241 -----rvpKQPLVCSLNANVAIEAVLNPASDIQASVDHLLLMKKLLNLSSAELYCEIIRACFMGLAN--GSSEDLKWPAF 313 
2_pfamImport  225 ------qtSGAVYHSILTLILLEVEERKLTNVEGIVQQLMLLSNVHGLTTRKLIFRLIQACFMLYLDavDTELEQEWCAM 298 
XP_018673004  232 ------pvSSTLCQSIMSLILLEVEERKLTNIEAIVQQLILLCNIHGLSTSNLIYHLIQTCFMGYLDsrGNDLEQEWCAM 305 
Q2PW47        234 --------VHTTFPSVHAFIMLEGTMNLTGETQPLVEQLMMIKRMQRIPAPLFVLEIWKACFTGLIEspEGNEELKWTAF 305  zebrafish
OCA45933      234 --------QRNGFPTVHAVVMLEGTMNLTGDAQPLVEQMNTVKRMQRIPSHLFLLEVWKACIVGLIEspEGTEELKWTAF 305 
Q7Q6D9        248 f---dggkVEPITYSLQPLIAIEVLLNPMCDTHQYVAQLINLKRLKGFTYARLYCELMRGCLIALNNveGTAKESLLCAF 324  African malar...
1_pfamImport  226 isdrevdvSEPLTYCVQALLAVQVMINPSADTAHLANQLRLLQKLKGYRMSRLCCEVIRACLMSLNDvlGLTEETKWGAF 305 
Q9VSF2        233 l--nppstLEKISCCVQPLLAVEVLLNPCKDTSYYVAELQMLQRLKKYSNTRLFYEIIRAGFLTLSNvaDTSPDTMWGAF 310  fruit fly
Q16X15        246 f---dgkgVEPITYCMQPLIAIDILFNPNCDTQMYVLEFLSIQALKGFPLSRLYCEIIRACLTCLNNvsGTSRESYICAF 322  yellow fever ...
EFN62777      306 -----kirMESITHCLQPLFAVQVLLNPSTETAVFVNQLLMVQRLKSYTNERLYCEIIRACLMCLHNvtGTFKESQWGAF 380 
6W1S_S        306 TYLKIPQVLVKLKKyfh-------------gekDFTEDVNCAFEFLLKLTPLLDKADQRCN-CDCTNFLLQECNKQGLLS 371  house mouse
EEC12065      314 TFLKVPQLLLKIHSark-------------ddrQWEEELEAGLMQLLNYTPLLDLTDSKCH-CDCLQYLLNELQKVELLT 379 
2_pfamImport  299 VFLRLPKIILQTKRtnyrhki------snnkiaEFNSDLEDALKMMLKLDSLLDTIDQLREgMNCIQLFTEQLMKKDRIN 372 
XP_018673004  306 VFLRLPKIMVQLKAqltgsdfespsklsskkiaQFGVDLQEALKMLLKLDSLLDTIDQICDgINCLKLLTEQFVKRELIT 385 
Q2PW47        306 TFLKIPQVLLRLKKypqg-----------ektqDFTEDVNVAFEYLLNLTPLLDKADQRCN-CDCLSLLLQECNKLGLLS 373  zebrafish
OCA45933      306 TFLKIPQALAKLKKlsp-------------meqDFNEDMKCAFEYLLKLTPLLDKADQRCN-CDCVSLLLQECNKLGLLS 371 
Q7Q6D9        325 AFIKVPHILHQLHAktngaeq-----qdeatgaTYSVEVLEAFELLLQDTPVLDYMDMKCA-CNVVECLLKEMVKLQLLT 398  African malar...
1_pfamImport  306 TFLKLPHILLSLTGsnlvssg------kyftdgDYSQDVAEAVQLLIQFVPLVDLMDSPIS-SNCIEALLTELTKLKLLN 378 
Q9VSF2        311 MFFKMPHIIKQLHAlqripg-------eqpppaDYIPELVEALELLIEDNLLLDFMDTKCS-CNMIEFLLNDWTKQQLVN 382  fruit fly
Q16X15        323 TFIKVPQIMRQIHLqtrvltpn----dfedaklDYSPDVVEAFELLLQDSAILDFMDAKCA-CNTVEYLLNEMLKHHLIN 397  yellow fever ...
EFN62777      381 TFLKVPLILKELHAatlns----------dekfEYSQDILDAFELLLQFTPLLDIMDSTCS-CNYVECLLNELQKVNLVT 449 
6W1S_S        372 EVNFASLVGKRTADRD--PQLKSSENANIQPnPGLILRAEPTVTNILKTM-DADHSKSPEGLLGVLGHMLSGKSLDLLLA 448  house mouse
EEC12065      380 EAQAKALMHRRQANTQk-QNLARQGPQTSQAgATLILKAEPTVTSILKSL-DADYSKNQDGLLGILCHMITGRSFELILS 457 
2_pfamImport  373 ESFHQELNKLR---SEmmEGMPSNNGQERCLnPVILLKADSTIEQLVKLFsSADFSAEPENLLSTFAGMRTMSSFNALTA 449 
XP_018673004  386 DAYHQDLQNIR---CSmiENMPVNNVKERCLnPVIILKAENNIDQLVKLLsSTDFS-EPERLLNTFAGMMSIRSFSALIA 461 
Q2PW47        374 EANTATLTAKRSEDREhaPRLKTAENANIQPnPGLILRAEPTVTNILKTV-DADHSKSPEGLLGVLGHMLSGKSLDLLLA 452  zebrafish
OCA45933      372 DQNLENLVAKRTADREqaPRMKSAENSTIQPnPGLILRAEPTVTNILKTM-DADHSKSPEGLLGVLGHMLSGKSLDLLLA 450 
Q7Q6D9        399 DTHVKQLVALREPVTAglHKLDANSAPLTMM-LKFVFRVESPLAGILKAL-STDCSKVQDALLAMLCQVLTGNSLDLVLS 476  African malar...
1_pfamImport  379 ETHISAYTASRDLVSSglSRLD-SGSPTSTPiLKVIIRAQPTLQRILKTL-DADYAKIQDALPNVLCQVLNGKSFELILS 456 
Q9VSF2        383 DVHVKKFASQREAASQllKKCD-NGQQTPSN-INFIKRAEVPLSGVLKTL-CT--NKVQD-MVNVLCQVPVGNSFELILS 456  fruit fly
Q16X15        398 EKYSKLIAAKRDGITSslQKLDLNTNQHSI--VKFVLRAEPPLVGILKTL-SSDYNKVQEALLGMLCQVLSGNSFELILS 474  yellow fever ...
EFN62777      450 EKQAKQISARREGVTAalQKLEPSNTPTSSI-PKVIIRAKPTLAGILKTL-NADYTKIQEALLSMLYHVLTGNSFELMLA 527 
6W1S_S        449 AAAATGKLKSFARKFINLNEFTTH-GSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSESSsgeeVP------FFE 521  house mouse
EEC12065      458 AAAATGKLNSFVKKLIKFNEYNKQ-ISGETTRNAQTRTLLFDITFLMLCHIVQNYGIHSVVFNEEt--rDS------FFT 528 
2_pfamImport  450 AAATTGQLADFASVLINCNNVMKS-SSAETMKSAQIRAVLFDITFLMVCYMIKLYDKEAIIVSFNaqskDEipillhWAN 528 
XP_018673004  462 AATTTGQLPAFANALIDCNDAMKS-CPAETSKNAQIRAVLFDITFLMVCYMIKLYGKETTVGSYIvrskEEtpillqWIN 540 
Q2PW47        453 AAAATGKLKSFARKFIKLNEFPKH-ISGEGSKSASVRALLFDISFLMLCHVVQTYGSEVILSDPSpsseTP------FFE 525  zebrafish
OCA45933      451 AAAATGKLKSFARKFIQLNEFTRH-IGVESSKAANVRALLFDISFLMLCHVAQTYGSEMILSEGCpsgeMP------FFE 523 
Q7Q6D9        477 VASVEGKFKAFISGLLKCNDYAKQaTTAEIGKAPTTRSALFDVSFMILASIAQSYGSDVILAEGG----NS------FFE 546  African malar...
1_pfamImport  457 VASVEGKLRTFVSKLIKFNECAKS--------GSTARPILFDITFVMLCSIVQTNGSRVVFEEGDrdgeKS------FFE 522 
Q9VSF2        457 VATVEGRLKTFVSRLIQCNENSKP-VPGDLGKLCVIRSTLFDVSFLMLTSIVQTYGSDVVLSERG----DS------FFE 525  fruit fly
Q16X15        475 VATVEGKLKTFVAGLIKCNENSKQ-VPGEMGKPAMTRAALFDVSFLMLVFIVQNYGSEGVLTDGT----DS------FFE 543  yellow fever ...
EFN62777      528 VATVEGKLKTFVAKLIKFNESSKQiNEPVPDKTAATRAMLFDVSFLMLCSIVQTYGSDVVLEEGG----DS------FFE 597 
6W1S_S        522 TWMQTCMPEEGKILNPDHPCFR-PDSTKVESLVALLNNSS----EMKLVQMKWHEACLSISAAILEILNAWENGVLAFES 596  house mouse
EEC12065      529 TWVPECLAEGGRYNCPEKMLAG-CDPAKVDLLLAQLMNNDn---DFMTNQVKWHEVCVNIPMAIKEILVAWEHGAISTDS 604 
2_pfamImport  529 TWWLDQINQISSVKYE-------SDPSRVENLIQVLRNSQ----EFKLSMTKWNDICINLPQAVIELLIARQKGAIQLSE 597 
XP_018673004  541 IWWTDKITQISTLKSE-------PEPNRVENLIPVLRSSQ----EFKLSMTKWNDICMNLPQSMIELLTARQKGIISITE 609 
Q2PW47        526 TWLQTCMPEEGKTLNPDHPCFR-PESGKVESLVALLNSSS----EMKLVQMKWHEICLSTPAAILEVLNAWENGVLSVEA 600  zebrafish
OCA45933      524 SWMQTCMPGEGRVLNPDHPCFRhPDIAKVEALVALLNTST----EMKLAQTKWHEVCLSIPAAILEIHNAWENGVLSFEA 599 
Q7Q6D9        547 KWVRDYMVERKKTKSPMTMVKQ-ADPMVLEELIMAMNNSEgmyvGLKASSLRWEDICYTIPALVHQVLMAWESESIAPLE 625  African malar...
1_pfamImport  523 RWAEECMIERGKPKCPDTMLKH-ADPVVVDALLAQLNSPQp---DLSNIGLGWDNICMSVAAAMKEVVIAWQQEALSVTD 598 
Q9VSF2        526 KWVRECMVERNKLKNPRQILAL-CDDSIVDELLLSFSKPEa--sQLKPNNLSWQETCLNLPGVLHHVLIAWEQETLSSAD 602  fruit fly
Q16X15        544 KWVRECMVEKHKSKSPMNMVKL-CDQNKVDELIVSLNSPD----GLKATSLKWQEICANIPGLLYQVLLAWENETLSTGE 618  yellow fever ...
EFN62777      598 QWVYECMPERNKPKSPQKMLQS-VDPARVDALLAQINSPDp---DFKSSNLKWHVACQSAMGAVKELLCAWESGVLGAGD 673 
6W1S_S        597 IQKITDNIKGK---VCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLA-GPLY---SENTLQF---------------Y 654  house mouse
EEC12065      605 VKMILDNVKSR---ICCLPVCISAWLCSYINVLHHQEQLKPMNMLQHFM-TPLS---TDASGNSegggdrpipqephslY 677 
2_pfamImport  598 VIRACCFIRDGcplAVTMSVIAAVARSARLVVAHKDH----IKVLSTLVeKS-----SVQSQSNm-------------mY 655 
XP_018673004  610 VVRACTLIKDGcplSVTLSVMAAVARCARLVVSRNDH----IQVLSALTeKSPT---QVQSLSNm-------------mY 669 
Q2PW47        601 VQKITDNIKGK---VCSMAICAVAWLVAHVRMLGLDEREKPQTMIRQLM-TPMS---GENTLQF---------------Y 658  zebrafish
OCA45933      600 IQKITDNIKGK---VCSLAVCAVAWLVAHVRMLGLDERDKSLQMIRQLG-SPMF---GDNTLQF---------------Y 657 
Q7Q6D9        626 IKKMLDGLKAY---FSTFAVCAASWLCAYMQMVRQDEQLKPMNMVQQLC-SALAgplADEWQQQd-------------yC 688  African malar...
1_pfamImport  599 VKRILDNMRQS---MCCLPICASAWLCSYMQILHQDALLKPMNMVQQFLsSPII---NEEGSQQd-------------tF 659 
Q9VSF2        603 VKSILDNIKRR---LFSFSVCATSFLCAYMYSVKETELLKPLNMIQQFL-APLT---SEELSSQe-------------nA 662  fruit fly
Q16X15        619 IKKFLDSLKSR---FCCFSICATSWLCAYMQIIRQDELLKPMNMIQQFV-TNIS---SEEMMQQe-------------yL 678  yellow fever ...
EFN62777      674 VKRALDGLRTA---ACCLPVCAAAWLCAYMSITHQDALLKPMNMVQHFL-TPLP---GDEMQDN---------------L 731 
6W1S_S        655 NERVVIMNSILEHMCADVLQQTATQIKFPSTgvdtMPYWnlLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHILDTLLHMG 734  house mouse
EEC12065      678 KERSLLMTNIVKKMMYDLHPPQQSKLKGPLV----ISHG--LTNKTPLWEIMDSVFSAAHARGWIDLRAIQSLDTLMCVG 751 
2_pfamImport  656 NERYIFFQSLCETIVSDLLPSLKQDGST-------------LDKNKLHSEVLQQTLSTTRKIGWINRDGIAKFSECFNML 722 
XP_018673004  670 NERFVFFQSVSSSIMSDLLPEFEPKTLN-------------LDKT-LHCTLLKQTFIEANQVGWINHAIITKFLDCYNML 735 
Q2PW47        659 HERVVIMSSILEHMCADVFQQTGLSLRPAVEgqepIPYRnlLPARLPIRQALQSQFRKVLEKGWVDSHAFHLFENLLHMG 738  zebrafish
OCA45933      658 NERVIIMSSILDNMCAEVLQQTATQIKFSAPgsepVPYIhrLPPKKPIKEVLRGAFSSTLEKGWVDSRTLHVFDTLLHMG 737 
Q7Q6D9        689 KERFGLMGQIVRRMQQEFLRTPQVNPKLRALfpsqQQQH--VVSHLPLEEQFEEAWKAIAERGWLPIETTFLLDTLLQSC 766  African malar...
1_pfamImport  660 KERSTLMVHIIRKMQYDMHLATSSKMKVIT-----F-----IISKEPMSEELAEIWSGVQEKGWLNISATHALESLFMTA 729 
Q9VSF2        663 KERLALSYQIIRKMQHDVHPAPSTKSR--------------LISHSPLVEQFREVWRTVVDAGHLPVRAAQSLESLLLAG 728  fruit fly
Q16X15        679 KERLGLTVQIIRKMQIDFQRLPVASPKMRNQl---QSQS--LVSQAPLEEQFEEVWKGVLEKGWLPIEATLALENLLQSC 753  yellow fever ...
EFN62777      732 KERSSLMFQIIRKMQYDVHPPTQSKTKVLS-----MSHS--IISRQPILEQLESVWQNINQRGWINIQATQSLESLLNTG 804 
6W1S_S        735 GVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALS 814  house mouse
EEC12065      752 GPQWFCDTLVRQALKHDHLEDLHRAIDLSFGLFHIDIEQCALALLTQVLPSYLLWETRQDSLTEPRGSALARLTVLTTFA 831 
2_pfamImport  723 GVFGFMRQAMKHILKETRLNEITTTVDIVFGIMRLDIISTTMYLLKHGIPDFLKQDSQ--PLASPLGRAIAKMAVAGLDL 800 
XP_018673004  736 GVCGFMRQTLNQILKETHLCGITNAVDIVFAVMRFDIVSTTMYLLKYGLPTFFKTNSR--PLAAPIGSAIAKLTVASLDI 813 
Q2PW47        739 GVFWFTNNLVKELLKETRKEWASRVVELLYSIFCLDTQQITLTLLGHILPRLLTDPAHWHSLADPPGRALAKLSVWCALS 818  zebrafish
OCA45933      738 GVYWFCNNLVKELLRETRLEFALRAVELLYAIFCLDMQQLTLTLLGHVLPSLLTDSAKWHMLMDPPGRALAKLSVWCAMT 817 
Q7Q6D9        767 GPAWLVEKLIGKLFVCKYVRDLNKTMDIIFAIMHLDIERCTIALLSQLVPMMLLNKAQTPDIVDPQSRVLAKLCVYCIIV 846  African malar...
1_pfamImport  730 GPQWFVISLVKEIMKLRYKEELDRAVDLALAVFHLDIETCTDYLLTTVLPQYLHNSILND-IVEPQSSALAKLCSYCIYA 808 
Q9VSF2        729 GAAWLSTQLVEQLLACKYTRDMSRTMDVVFAVMHLDIEKTTEALLQYVVAPLILRR-QGEDINEPQSLVLARLCVYCIIS 807  fruit fly
Q16X15        754 GPFWLVDKLVQQIFHCKYIREMNKTMDIVFAIMHLDIERCTIALLSQLVPMMLLNKLQISEIVDPFSRVLAKLCVYCIVA 833  yellow fever ...
EFN62777      805 GSLWFVTNIVKEVLKYRYQEELDQAVDLAFAIFHLDIENCTLDLINHIIPQYLHNSLQNDELVEPQSSILAKLCVYCIFS 884 
6W1S_S        815 SYSsh---kgQASSRQKKRHRE---------------------DIEDYVSLfpvedMQPSKLMRL------------LSS 858  house mouse
EEC12065      832 ALQvrtsqpsVGTQRGGHKRPHw--------------------DMELEEAMdeskrVRPNKMRRGln--------dsELL 883 
2_pfamImport  801 ALNesalqqkSQLPPSKRQNPFsqn---------------valNRQ----------SGQHKVRRL--------------- 840 
XP_018673004  814 ALNeitlqqkSLLPKSRKQNPMlqn---------------ivfDKQ-------------QKVRRL--------------- 850 
Q2PW47        819 SYSshh--kgQASARQRKRHRE---------------------DIEDYTSLfplddTQPSKLMRL------------LSS 863  zebrafish
OCA45933      818 SYStqn--kgQPSPRQRKRHRE---------------------DIEDYSSLfplddTQQSKLMRL------------LSS 862 
Q7Q6D9        847 TME-------TSLTATKKRTRGta-----------------ssELEDLDAL-----CTSAKLRKIeldgmgvgcteaATG 897  African malar...
1_pfamImport  809 AWQsqssytrKRPLQEKSAADMaaelvlcynmpapadrlfswsDLSDL---------LPTKLLRL--------------- 864 
Q9VSF2        808 CLEsrkgngtSALTAMKKRSRSh--------------------DDEELA-------ANAAKVRKVigdgsdnssdftDTT 860  fruit fly
Q16X15        834 TME-------APAVPTKKRSRAai-----------------taEGDELDTL-----CSTPKMRKIg----------sESC 874  yellow fever ...
EFN62777      885 TLEyi----nSNPYRGNNRKRVrr-----------------elDADELDPL-----SMSNKLLRL--------------- 923 
6W1S_S        859 SDDDANILSSPTDRSMNSslsasqlhtvnmrDPLNRVLANLFLLISsILGSR-TAGPHTQFVQWFMEECVGCLEQDSRgS 937  house mouse
EEC12065      884 DDTPFALQCHSEENYRSL-------------DPLSKAVVDTMRLLM-VIASDsVISQRSVFPLLLFEQVVLCAGDEAH-R 948 
2_pfamImport  841 ----------FSCSTEHDlsipg----ltfdDPLVHILSEFIDVMWcSLEAN-THGPQSEFVLEFVKLSLQASPLLSR-T 904 
XP_018673004  851 -----------FSQTEHDlpppgstpglpaeDPLIQVLSDFMDLLWnSMESN-EGGPQADFIFKFIKLSLESSSLLSR-T 917 
Q2PW47        864 NEDENSMLSSPGDRSISSslsasqlhtvnmrDPLNRVLANLFLLISsQLGSK-TAGPHTQFVQSFVEECVDCSEQGSRsS 942  zebrafish
OCA45933      863 NEEEHSVQANPVDRPMNSslsasqihnisskEPLNRVLANLFLLISsVLGAK-TAGAQTQFVQWFMEECVESLELGGKgC 941 
Q7Q6D9        898 GASGTEFSLDSALEPTASawtteaasiatlkEPLQSCLQTLFRTFAqHIATD-ELSPKVYFVFQFLSLLVESGRERIM-C 975  African malar...
1_pfamImport  865 EEGPMTLKGSASEQQQVQvpp--------lrPPLSNSLKIMFNSFSlITEHIpYISQQTHFVFRVLELLVTCGRDQTR-P 935 
Q9VSF2        861 TGAGLAALLGSTSTSELRttpl------tlrEPLQTSVQHIFAVFLqFVSGD-ELSPKAVFVYQFISLLVECGGERVA-P 932  fruit fly
Q16X15        875 DSSSSDFMLEQVLAARDNpap--------lkEPLQGCLQTLFRTFSqYIVSD-ELSPKIFFMFQLLSLLVEVGKDRIK-P 944  yellow fever ...
EFN62777      924 NETGESIPMYGSQSPQVQstsngqkseiilkDPLMTALNNLFTIFSfLAGRDgEISQQTHFIFQFLRLTVQCGKDRTR-I 1002
6W1S_S        938 ILQFMPFTTVSELVKV--SAMSSPKVVLAITDLSLPLGRQVAAKAIA 982  house mouse
EEC12065      949 VLQFAPLGLVPQLVRSm-PHLMSHQLVLALSSLQTSRARKVAARATC 994 
2_pfamImport  905 VKRLIPIPMIRELRYSlvNH--SRELLFAACDLGNPEIRKLAAHAVC 949 
XP_018673004  918 VKLHIPVPMLSKLRYPlaKD--SHVLLFAASDMGNEEIRKLAAHAIC 962 
Q2PW47        943 ILQFMPFTMISELVKL--QSLAKPKTVLSITDLSLPLGRRMAAKAIA 987  zebrafish
OCA45933      942 ILQFMPFSMVSELVKV--STLSSPKIVLAITDLTLPLGRRVAAKALT 986 
Q7Q6D9        976 VLKLLPNGLVQSLLKInaTDEMTVGLILRLYDLNTPSGRQFAMSDIC 1022 African malaria mosquito
1_pfamImport  936 VLQDMPNTLVPSLLRAl-PNLFSTDLVLRLYDLTSPAGRKATASDLC 981 
Q9VSF2        933 VLRLLPNGLVQQLLKVlvTDDIKVGLISRLYDLRIQAGRLSAVSDLC 979  fruit fly
Q16X15        945 VLKLIPNGLIQNMMKInaTDDMTVGFILRLYDLNTASGRQFAMSDLC 991  yellow fever mosquito
EFN62777     1003 VLQGMPQTLVPCLLKAl-PELFTTDILLRLYDIQTIIGRKATARDLC 1048
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