4KQ8,5JKW


Conserved Protein Domain Family
CYP19A1

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cd20616: CYP19A1 
Click on image for an interactive view with Cn3D
cytochrome P450 family 19, subfamily A, polypeptide 1
CYP19A1, also called aromatase or estrogen synthetase (EC 1.14.14.14), catalyzes the formation of aromatic C18 estrogens from C19 androgens. The CYP19A1 subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410709
Aligned: 19 rows
Threshold Bit Score: 672.918
Created: 15-Aug-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:4KQ8: Human CYP19A1 binds heme; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #       #                ##       #   #      
4KQ8_A     38 SACNYYNRvyGEFMRVWIsgeETLIISkSSSMFHIMKHNHYSSRFGSKLGLQcigmhekGIIFNNNPELWKTTRPFFMKA 117 human
AAH79750   70 KAANYYNNmyGEFVRVWIngeETLIISkSSATFHIMKHSHYVSRFGSKLGLQcigmnenGIIFNSNPSLWKVIRPYFIRA 149 African clawed frog
O42145     92 TASNYYNSkyGDIVRVWIngeETLILSrSSAVYHVLRKSLYTSRFGSKLGLQcigmheqGIIFNSNVALWKKVRAFYAKA 171 zebrafish
P19098     71 NACNYYNKtyGEFVRVWIsgeETFIISkSSSVFHVMKHWNYVSRFGSKLGLQcigmyenGIIFNNNPAHWKEIRPFFTKA 150 chicken
Q29624     72 SACNYYNKtyGEFIRVWIggeETLIISkSSSVFHVMKHSHYTSRFGSKPGLQfigmhekGIIFNNNPVLWKAVRTYFMKA 151 pig
P79430     72 SACNYYNEmyGEFMRVWIggeETLIISkSSSVFHVMKHSHYTSRFGSKPGLEcigmyekGIIFNNDPALWKAVRTYFMKA 151 pig
Q92111     93 TASNYYNEkyGDMVRVWIsgeETLVLSrPSAVYHVLKHSQYTSRFGSKLGLQcigmheqGIIFNSNVTLWRKVRTYFAKA 172 channel catfish
P79690     71 SACNYYNEkyGSIARVWIsgeETFILSkSSAVYHVLKSNNYTGRFASKKGLQcigmfeqGIIFNSNMALWKKVRTYFTKA 150 goldfish
O73686     92 TASNYYNSkyGDIVRVWIngeETLILSrSSAVYHVLRKSLYTSRFGSKLGLQcigmheqGIIFNSNVALWKKVRSFYAKA 171 goldfish
Q6QHT9     86 TASNYYNEryGDIVRVWIngeETIILSrSSAVYQVLRKPQYTSRFGSKQGLRcigmherGIIFNNNIELWKKVRTYFAKA 165 Japanese eel
Feature 1     #                                                                               
4KQ8_A    118 LsgpglVRMVTVCAESLKTHLDRLEEvtnesgyVDVLTLLRRVMLDTSNTLFLriplDESAIVVKIQGYFDAWQALLIKP 197 human
AAH79750  150 LsgpglMQTTENCIRSTNHYLDNLSNvtnelgnVDVLKLMRLIMLDTSNNLFLriplDENEIVLKIQKYFDAWQALLLKP 229 African clawed frog
O42145    172 LtgpglQRTMEICTTSTNSHLDDLSQltdaqgqLDILNLLRCIVVDVSNRLFLgvplNEHDLLQKIHKYFDTWQTVLIKP 251 zebrafish
P19098    151 LsgpglVRMIAICVESTIVHLDKLEEvttevgnVNVLNLMRRIMLDTSNKLFLgvplDESAIVLKIQNYFDAWQALLLKP 230 chicken
Q29624    152 LsgpglVRMVTVCADSITKHLDKLEEvrndlgyVDVLTLMRRIMLDTSNNLFLgiplDEKAIVCKIQGYFDAWQALLLKP 231 pig
P79430    152 LsgpglVRMVTVCADSITKHLDKLEEvrndlgyVDVLTLMRRIMLDTSNNLFLgiplDEKAIVCKIQGYFDAWQALLLKP 231 pig
Q92111    173 LtgpglQRTLEICTMSTNTHLDGLSRltdaqghVDVLNLLRCIVVDISNRLFLdvplNEQNLLFKIHRYFETWQTVLIKP 252 channel catfish
P79690    151 LtgpglQKSVDVCVSATNKQLNVLQEftdhsghVDVLNLLRCIVVDVSNRLFLriplNEKDLLIKIHRYFSTWQAVLIQP 230 goldfish
O73686    172 LtgpglQRTLEICITSTNTHLDNLSHlmdargqVDILNLLRCIVVDISNRLFLgvplNEHDLLQKIHKYFDTWQTVLIKP 251 goldfish
Q6QHT9    166 LtgpglQRTVAICVASTDSHLDQLEEltdlsgqVDILNLLRCTIVDISNQMFLrvplNEKELLVKIQKYFEAWQTVLIRP 245 Japanese eel
Feature 1                                                                                #   #
4KQ8_A    198 dif-fkiSWLYKKYEKSVKDLKDAIEVLIAEKRRRISteekleecMDFATELILAEKRGdltRENVNQCILEMLIAAPDT 276 human
AAH79750  230 dif-fkiSWLYKKYEKSANDLKEAIELLIEQKRQKLSssekldedMDFSSELIFAQNHGdltAENVNQCILEMLIAAPDT 308 African clawed frog
O42145    252 dvy-frlDWLHRKHKRDAQELQDAITALIEQKKVQLAhaek-ldhLDFTAELIFAQSHGelsAENVRQCVLEMVIAAPDT 329 zebrafish
P19098    231 dif-fkiSWLCKKYEEAAKDLKGAMEILIEQKRQKLStvekldehMDFASQLIFAQNRGdltAENVNQCVLEMMIAAPDT 309 chicken
Q29624    232 dif-fkiPWLYRKYEKSVKDLKEDMEILIEKKRRRIFtaekledcMDFATELILAEKRGeltKENVNQCILEMLIAAPDT 310 pig
P79430    232 eff-fkfSWLYKKHKESVKDLKENMEILIEKKRCSIItaekledcMDFATELILAEKRGeltKENVNQCILEMLIAAPDT 310 pig
Q92111    253 dfy-frlKWLHDKHRNAAQELHDAIEDLIEQKRTELQqaek-ldnLNFTEELIFAQSHGeltAENVRQCVLEMVIAAPDT 330 channel catfish
P79690    231 dvf-frlNFVYKKYHLAAKELQDEMGKLVEQKRQAINnmek-ldeTDFATELIFAQNHDelsVDDVRQCVLEMVIAAPDT 308 goldfish
O73686    252 dvyfrlaWWLHRKHKRDAQELQDAIAALIEQKRVQLTraek-fdqLDFTAELIFAQSHGelsTENVRQCVLEMIIAAPDT 330 goldfish
Q6QHT9    246 dfl-fkfEWMYKEHKEAAHELHEAMEILVEKKRKALEeaek-lddADFATDLIFAQNHGelsAENVQQCILEMIIAAPDT 323 Japanese eel
Feature 1     #                                                    #     #  # #               
4KQ8_A    277 MSVSLFFMLFLIAKHpnVEEAIIKEIQTvigerdikidDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIdgYPVKK 356 human
AAH79750  309 MSVSLFFMLVLIAQHpkIEEGIMNEMDKvigdrdvesnDIPNLKILESFIYESMRYQPVVDLVMRKALEDDIIdgYYVKK 388 African clawed frog
O42145    330 LSISLFFMLLLLKQNpdVELKILQEMDSvlagqslqhsHLSKLQILESFINESLRFHPVVDFTMRRALDDDVIegYNVKK 409 zebrafish
P19098    310 LSVTLFIMLILIADDptVEEKMMREIETvmgdrevqsdDMPNLKIVENFIYESMRYQPVVDLIMRKALQDDVIdgYPVKK 389 chicken
Q29624    311 MSVTVFFMLFLIAKHpqVEEELMKEIQTvvgerdirndDMQKLEVVENFIYESMRYQPVVDLVMRKALEDDVIdgYPVKK 390 pig
P79430    311 LSVTVFFMLFLIAKHpqVEEAIVKEIQTvigerdirndDMQKLKVVENFIYESMRYQPVVDLVMRKALEDDVIdgYPVKK 390 pig
Q92111    331 LSISVFFMLLLLKQNaeVERRILTEIHTvlgdtelqhsHLSQLHVLECFINEALRFHPVVDFSYRRALDDDVIegFRVPR 410 channel catfish
P79690    309 LSISLFFMLLLLKQNsvVEEQIVQEIQSqigerdvesaDLQKLNVLERFIKESLRFHPVVDFIMRRALEDDEIdgYRVAK 388 goldfish
O73686    331 LSISLFFMLLLLKQNpdVELKILQEMNAvlagrslqhsHLSGFHILESFINESLRFHPVVDFTMRRALDDDVIegYKVKR 410 goldfish
Q6QHT9    324 MSISLFFMLMLLKQNpeVEQEILKELDTvigdkkaensNLQHLIIMESFINESLRYHPVVDFTMRKSLEDDVIegYKVFK 403 Japanese eel
Feature 1                                           ###   #####      ##                       
4KQ8_A    357 GTNIILNIGRMHrleffpKPNEFTLENFAKNVPyrYFQPFGFGpRGCAGKYIAMVMMKAILVTLLRRFHvktlqGQCVES 436 human
AAH79750  389 GTNIILNLGRMHkieyfpKPNEFTLENFEKTVPyrYFQPFGSGpRACAGKYIAMVMMKVILVTLLKRYKvqtlrGRCLEN 468 African clawed frog
O42145    410 GTNIILNVGRMHrseffsKPNQFSLDNFHKNVPsrFFQPFGSGpRSCVGKHIAMVMMKSILVALLSRFSvcpmkACTVEN 489 zebrafish
P19098    390 GTNIILNIGRMHkleffpKPNEFSLENFEKNVPsrYFQPFGFGpRGCVGKFIAMVMMKAILVTLLRRCRvqtmkGRGLNN 469 chicken
Q29624    391 GTNIILNIGRMHrleffpKPNEFTLENFAKNVPyrYFQPFGFGpRACAGKYIAMVMMKVTLVILLRRFQvqtpqDRCVEK 470 pig
P79430    391 GTNIILNIGRMHrleffpKPNEFTLENFAKNVPyrYFQPFGFGpRACAGKYIAMVMMKVTLVILLRRFQvqtpqDRCVEK 470 pig
Q92111    411 GTNIILNVGRMHrsefypKPADFSLDNFNKPVPsrFFQPFGSGpRSCVGKHIAMVMMKAVLLMVLSRFSvcpeeSCTVEN 490 channel catfish
P79690    389 GTNLILNIGRMHkseffqKPNEFNLENFENTVPsrYFQPFGCGpRACVGKHIAMVMTKAILVTLLSRFTvcprhGCTVST 468 goldfish
O73686    411 GTNIILNVGRMHrseffpKPNEFSLDNFQKNVPsrFFQPFGSGpRSCVGKHMAMVMMKSILVTLLSRFSvcpvkGCTVDS 490 goldfish
Q6QHT9    404 GTNIILNVGRMHkceffsKPNEFSLENFEKTVPnrFFQPFGSGpRSCVGKHISMVMMKAILATLLSRYTmcprdGRTLNN 483 Japanese eel
Feature 1                    
4KQ8_A    437 IQKIHDLslHPDETK 451 human
AAH79750  469 IQNNNDLsmHPDESQ 483 African clawed frog
O42145    490 IPQTNNLsqQPVEEP 504 zebrafish
P19098    470 IQKNNDLsmHPIERQ 484 chicken
Q29624    471 MQKKNDLslHPDETS 485 pig
P79430    471 MQKKNDLslHPDETS 485 pig
Q92111    491 IAHTNDLsqQPVEDK 505 channel catfish
P79690    469 IKQTNNLsmQPVEED 483 goldfish
O73686    491 IPQTNDLsqQPVEEP 505 goldfish
Q6QHT9    484 IRKTNNLsqQLAEKD 498 Japanese eel

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