Conserved Protein Domain Family
RUN_RUNDC3B
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cd17700: RUN_RUNDC3B 
RUN domain found in RUN domain-containing protein 3B (RUNDC3B) and similar proteins
RUN domain-containing protein 3B (RUNDC3B), also called Rap2-binding protein 9, or Rap2-interacting protein 9 (RPIP-9), contains a RUN domain in its N-terminal region that mediates interaction with Rap2, an important component of the Mitogen-Activated Protein Kinase (MAPK) cascade, which regulates cellular proliferation and differentiation. It also contains characteristic binding sites for MAPK intermediates. RUNDC3B contains a RUN domain.
Links
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Statistics
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PSSM-Id: 439062
Aligned: 6 rows
Threshold Bit Score: 286.48
Created: 10-Mar-2016
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q96NL0        35 NLITVCRFSVKTLIDRSCFETIDDsspEFNNFAAILEQILSHRLKeisqscrwlahlqiplqgqvtWFGYESPRSFWDYI 114 human
XP_007896343  26 NLITVCRFSVKTLIDRSCFETIDDtcfEFTNFAAILEQVLSHRLKgq-----------------inWFGYESPRSFWDFI 88  elephant shark
NP_001026143  29 NLITVCRFSVKTLIDRSCFETIDDsspEFNNFAAILEQILSHRLKgq-----------------itWFGYESTRSFWDYI 91  chicken
NP_989082     26 NLLTVCRLSVKTLIDRSCFETIDDsapEFVNFASILEQILSHRLKgq-----------------vtWFGYESPRSFWDYI 88  western clawed ...
XP_005998555  26 NLITVCRFSVKTLIDRSCFETIDDsspEFVNFAAILEQILSHRFKgq-----------------itWFGYESPRSFWDYI 88  coelacanth
NP_001007417  26 NLITVCRFSVKTLIDRSCFETIDDtsaEFINFVSILEHILSHRLKgq-----------------vsWFGYESPRSFWDFI 88  zebrafish

Q96NL0       115 RVACrKVSQNCICSIENMENVsSSRAKGRAWIRVALMEKhLSEYISTALRDfkTTRRFYEDGAIVLGEEANMLAGMLLGL 194 human
XP_007896343  89 RVACsKVPHNCISSIENMENVsSTRAKGRAWIRVALMEKrLSEYISTSLRDirTIRRYYEDGAIVLGEEANMLAGMLLGL 168 elephant shark
NP_001026143  92 RVACrKVSHNCICSIENMENVgSSRAKGRAWIRVALMEKhLSEYISTALRDfkTTRRFYEDGAIVLGEEANMLAGMLLGL 171 chicken
NP_989082     89 RVACsKVSHSCICSIENMENVsSSRAKGRAWIRVALMEKrLSEYITAALRDykTTRRFYDDGAIVLGEEANMLAGMLLGL 168 western clawed ...
XP_005998555  89 RIACsKVPHNCISSIENMENVsSSRAKGRAWIRVALMEKrLSEYISTALREnkITRRFYEDGAILMGEAANMVAGMLLGL 168 coelacanth
NP_001007417  89 RMACsKVPHSCIHSIENMENVrSSRAKGRAWIRVALMEKrLSEYISAALRDfkTTRRFYEEGALLLGEEAGLLADTLIGL 168 zebrafish

Q96NL0       195 NAIDFSFC 202 human
XP_007896343 169 NAIDFSFC 176 elephant shark
NP_001026143 172 NAIDFSFC 179 chicken
NP_989082    169 NAIDFSFC 176 western clawed frog
XP_005998555 169 NAIDFSFC 176 coelacanth
NP_001007417 169 NAIDFSFC 176 zebrafish
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