Conserved Protein Domain Family
Synaphin
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pfam05835: Synaphin 
Synaphin protein
This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerization of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles. Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion.
Links
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Statistics
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PSSM-Id: 461755
Aligned: 22 rows
Threshold Bit Score: 57.0786
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006639899          1 MSFLLKTMVGSPMKNLSGGG----GggGGEEEKKVEgdgketaeskgMTREEFEEYQRQLVEEKIERDKQFAQKKAERAS 76 
Q6DHG4                1 MNFLLKAAMGGGPPDVGKML----GgeE-DKDPEAE-------------KEKEEERQEALRQEEEERKAKHAKMEAEREN 62  zebrafish
Q4RJ93                1 MNFVMKAALGGGPPDVGKML----GgeEKEQDPDAA--------------KKEEERQEALRQQEEERKAKYAKMEAERER 62  spotted ...
XP_015788879          2 AAFIAKQMVGNQLSAVKD-I----Gg-GGDSAEDKE-----------KLEELERERLEALREAEERRREKHRKMEEEREK 64 
WGS:AAPP:GF18201-PA   2 AAFIAKQMVGNQLSAVKGAV----GgdGGDDGDDKE-----------KAEEEERERQEAIREAEERRKEKHRKMEEEREK 66 
EFX87986              2 AAFVAKQMLGSKMNAVKG-L----GgnDSEDGDTKD-----------KDDEAERERLEAIKEAEDRRKEKHRKMEVEREN 65 
BAH72407              2 AAFVAKQVVGNKLNAVKGAV----Gd-GGESAEDKE-----------KNAEAERERLEAIREAEERRKEKHRKMEEEREK 65 
EFO21969              2 ASFIMKQMVGGKLNEMKGGIdkltGdkDGEGGEKTE-------------SGEDPEVVAARLEQEERRKERHRKMEREREK 68 
EKC20981              2 AAFIAKQMVGNQLKSVKGAI----GggDKEGEGENKed--------aGGGGEDPEVEEMRREAERKRKEKHEKAEAEREE 69 
XP_009015915          2 vsLLGGGLFGNPLSGVTNAL----GdkDEKDDKNAE--------------EEDPEIAEAKREAEEKRNEKYRKMEEEREA 63 

XP_006639899         77 LRMHMRGKYRLPQSEKDDAQV----QIV-----------GGDVDLPEDLAKMVEQDEEEEEANDSLLGKIQNM-ELDFDV 140
Q6DHG4               63 IRQGIRDKYGIKKREVAEAEE----AAAmeqac--egsmTRPKK-----AVPSGCGDDDEEE--NIMDTVMKYlPGPLQD 129 zebrafish
Q4RJ93               63 MRQGIRDKYGLKKREEAEAEA----AAAaeepa--agslTRPKK-----AVPAGCGDEEEEE--SIMDTVMKYlPGPLQD 129 spotted ...
XP_015788879         65 MRQGVREKYGIKKKEEKEEEMrkqqEALmggst--dgglNRAKKTPEELAAEAAAQEQDE------FTKIKTTiETQVNE 136
WGS:AAPP:GF18201-PA  67 MRQDIRDKYNIKKKEEIV-------EAApqee---pnplMRKKKTPEELAAEAEQEELDD------FTKLKNQiETQVNE 130
EFX87986             66 MRQDIRDKYNIKKKEEAP-------EAEtlkep--dnplMRKKKTPEELAKEAEEADQDE------LTKLKNTlETQVNE 130
BAH72407             66 MRQEIRDKYNIKKKEELP-------EPVqeep---anplMRKKKTPEELAKEAEMEEEDE------FTKLKNTiETQVNE 129
EFO21969             69 MRQDIRSKYNIQKKEDGIS------GIPfdtstdgrivgPSMKKTPQQIAQEME-DDDSLIGQLG-LTEQVEKaKTAVNE 140
EKC20981             70 LRQSIRDKYGLKKKVPEEE------NMMlnndd--ggrvGRKKKTPAELAAEANADSDDDEFT---MPKNMDElKNKVQD 138
XP_009015915         64 MRQTIRDKYHIQKKE----------IPKedpgl--egrlGRKKKTPEELAMESDPNYDPSGNN-SVFPKNLDElTSRVKE 130

XP_006639899        141 IKT 143
Q6DHG4              130 MLK 132 zebrafish
Q4RJ93              130 MLK 132 spotted green pufferfish
XP_015788879        137 LKS 139
WGS:AAPP:GF18201-PA 131 LKT 133
EFX87986            131 WKS 133
BAH72407            130 LKS 132
EFO21969            141 Ale 143
EKC20981            139 IPQ 141
XP_009015915        131 LPN 133
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