6W4S


Conserved Protein Domain Family
FPN1

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pfam06963: FPN1 
Ferroportin1 (FPN1)
This family represents a conserved region approximately 100 residues long within eukaryotic Ferroportin1 (FPN1), a protein that may play a role in iron export from the cell. This family may represent a number of transmembrane regions in Ferroportin1.
Statistics
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PSSM-Id: 462052
Aligned: 16 rows
Threshold Bit Score: 428.26
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W4S_F        22 TSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGnSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLK--VAQTSLVVQ 99  human
Q8W4E7       146 PEGLYVLYASCLVGNLVEQLWNFAWPSAIAMLYP-SLLPVAVMGFVTKLAIIAGGPVVGKFMDYSPRVP--TYISLNVIQ 222 thale cress
KIS70817      82 ARGTLLLAVQHATLSWGYRSAEFAYPLMMVQLFTnTLLPASIYGFVTTAGAILFSNNVGRLIDTYAHLKlrTLRAMILSQ 161
Q5AXY5        19 NRVLLRLYTSHFLSTWNSRMFEFGAVVFLASIFPgTLLYASVYALVRSLFAVLFSSWLGSLVDRTDRLS--AIRHSIIWQ 96  Aspergillus nid...
Q0CWF0        44 KHVLFRLYVSHTLSTWNSRMFEFGSVLFLASIFPgTLLYASIYALGRSLSAVLLSSWLGSMVDRSNRLT--TIRHSII-- 119 Aspergillus ter...
XP_001401251  42 TRILFRLYISHFLSTWNSRMFEFGAVLFLATIFPgTLRYTSVYALVRSLSAVVLSSWLGSVVDRANRLR--AIRHSIIWQ 119
XP_001274573  39 KHVLARLYVSHFLSTWNSRMFEFGAILFLASIFQdTLLYASVYALARSLSAVVLSSWLGSRMDHSDRLV--TIRRSIIWQ 116
XP_003966250  42 rgPKFLIYVSGALSMWGDRMWHFAISVFLIELYGrNLLLTAVFGLVVAGSVLLLGALIGDWVDRNPRNK--VAHASLFIQ 119
Q9I9R3        19 KSAKFLIYVGHALSTWGDRMWNFAVAVFLVELYGnSLLLTAVYGLVVAGSVLLLGAIIGDWVDKNPRLK--VAQTSLVVQ 96  zebrafish
Q8IA95         5 SGKELQLNSAFLLTTLGDRMWAFVIGLFMHQLg--GMTWVAVQQLVDSVLKLVVITIVGQYLDKIDRSK--IIQRTLLLN 80  Caenorhabditis ...
6W4S_F       100 NVSVILCGIILMMVFLHKHELLTmy----------hGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVA-GEDRS 168 human
Q8W4E7       223 AAAQVLSAGMIIHAYTVPSTSAS-------------SILLQPWFFALLFAGAIDSLCGIASGVAIERDWVVLLAgINRPI 289 thale cress
KIS70817     162 KLLVGASYGLFLILFSSTSLRMEaenggkgpqdaraNARPWVFFAAITLLGIGVMLSNVGVSVGVEREWVTIIS-DGSSA 240
Q5AXY5        97 RIPVAVSCVCLGLLLRSPP-----------------GHLSRLLFIALVLLAGVEKLAATVNTVSVERDWAVVIS-ETLLV 158 Aspergillus nid...
Q0CWF0       120 ----AASCACFVHLLNRSSEL---------------TYFSPLLFTAIALLACVEKLAANVNTVSVERDWAVVIS-DALQY 179 Aspergillus ter...
XP_001401251 120 RIPVAASCACFTVLLAPTT-----------------TAITSLVFAGTVLLACVEKLAATANCVAVERDWAIVVS-DALDI 181
XP_001274573 117 RLPVVLSCACFVVLLVPSLMGN--------------KFVTWGLFAAVLLLACVEKLAAIANTVAVERDWAIIVS-DSLAI 181
XP_003966250 120 NISVTVCSIVLMLVFLYKQRIEQiw----------dGWLTVVCYTVVIVLADVANLASTALTIAIQRDWIVVIT-GYNRG 188
Q9I9R3        97 NSAVILCGALLMAVFQFKQQLSSmy----------dGWLLTTCYIMVISIANIANLASTAMSITIQRDWVVVVA-GDDRS 165 zebrafish
Q8IA95        81 NAAVAVSAGLFAYMFVHKT-----------------DHYATPVLLMASAVASIAKVASEIQRISFTKDWVVVIS-QSESV 142 Caenorhabditis ...
6W4S_F       169 KLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKE-EETELK 247 human
Q8W4E7       290 ALAQANAVLHRIDLLCEIAGTMLFGILLSKYDPVTCLKFAATLMVGSLPTMTALIWLTNKFSSGVLDRPKCSLnSCSAEG 369 thale cress
KIS70817     241 RLTRLNAIMRRIDLISKLVSPLFVSALTSTMGYTLAAVVLFSVNAVTGIFELIFVGTVYRRFPSLANDEKVAIaRRQTAA 320
Q5AXY5       159 SRKDLNASMRRIDLFCKLVAPVVVSLMDGLLSTKVAIWAVLGVNVTVVLVEYFAIAGVYHSVPQLDRSHERQAaDDEEDE 238 Aspergillus nid...
Q0CWF0       180 SRQGLNASMRRIDLICKLLAPVVISFLDG-FSTRAAIWTVLGVNVSCVVVEYIAIAQVYKVVPELERHRDASEnEEDGAN 258 Aspergillus ter...
XP_001401251 182 PRQDLNASMRRIDLFCKLLAPVVISVIDG-LSTKIAIWTVLVVNVSCVVLEYIAIAQVYTSIPELKRCQDESSeIGDGPG 260
XP_001274573 182 QRQDLNASMRQIDLFCKLLAPLMVSLIDS-LSTSIAVWLVLAVNILCVFVEYVAIAQVYEAIPELRRVQRGLAtNDGENG 260
XP_003966250 189 HLAGMNATMRRIDQVTNILAPLAVGQVMTLASNVVGCGFILGWNLVSLIVEFFFLSRVYRIVPALSIKPPVEEeEQNPVY 268
Q9I9R3       166 KLADMNATVRIIDQLTNILAPMLVGQIMAFGSHFIGCGFISGWNLFSMCLEYFLLWKVYQKTPALAFKAGQKDsDDQELK 245 zebrafish
Q8IA95       143 DLAKVNSILLCIDQISSAILPTLTGELLDTFKWQYVCGFIIVYNLASWVIESMILRRLYNETPQLKTRASEITgDEE--- 219 Caenorhabditis ...
6W4S_F       248 QlnlhkdtepkplegthlmgvkdsniheleheqEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMT-VLGFDC 326 human
Q8W4E7       370 S--------------------------------RTNTDSIFDIGMETIKLGWKEYIQQPVLPASLAYVLLYFNiVLTPGS 417 thale cress
KIS70817     321 Eastdssacrepsl-------saqgtkarlaklTSLLVASVVEDVKQQYHDWKLFVRLPIFLTSLCISLLYMS-VLSFDP 392
Q5AXY5       239 Qqp----------------------------leEHLAQNIFAQYIRRTVAPWREYVGQSVFLASFALSLLYLT-VLSFGP 289 Aspergillus nid...
Q0CWF0       259 Hvqd--------------------------snsHRAGIYSVVRYIHRAVAPWKEYVSSRVFLASFSLSLLYLT-VLSFGT 311 Aspergillus ter...
XP_001401251 261 Lepqd-------------------------ggsAPTAARRIAQYSRKALAPWREYVASSVFLASLALSLLYLT-VLSFGT 314
XP_001274573 261 Eddfqp----------------------tsravQRSVVNRAARLLNHVAAPWREYIASPVFLASFSLSLLYLT-VLSFGP 317
XP_003966250 269 Egnttqaepltegn-------cdtslhlkeitnLPLCFRRFRWLVSTCKDGWKAYYRQPVFLAGMGLAFLYTT-VLGFDC 340
Q9I9R3       246 Hlniqkeigntespv----easqlmtessepkkDTGCCYQMAEPIRTFKDGWVAYYNQSIFFAGMSLAFLYMT-VLGFDC 320 zebrafish
Q8IA95       220 ----------------------------------LRGLKGVKLNSITQ------YFKQQSWTAGFGLSLLYMT-VLGFDN 258 Caenorhabditis ...
6W4S_F       327 ITTGYAYTQ-GLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPldlsvspf 405 human
Q8W4E7       418 LMTAFLTQR-CVNPSVIGGFSGLCAVMGVAATFLSANLVKRVGILKAGAVGLFFQASLLAVAVAVYCSSSLS-------- 488 thale cress
KIS70817     393 TFIAYLKSEtLYSDAFIAGMRAVGVVTGLMGTFAMPLLEKRIGLVRTGSYSLFAELIPLVPAVVSLWITGSPsdrfgl-- 470
Q5AXY5       290 TMVTFLLHS-GFSSLDVSAMRIGAVLTEISGTWMAPLLMDRIGPIRSGLWFLNWQFGTLAAAVAAFAFASDR-------- 360 Aspergillus nid...
Q0CWF0       312 TMVTYLLHT-GFSALEVSCMRIGAVVAELSGTWAAPIVMNRIGPIRSGLWFLNWQFGCLAAAVAGFAFLERN-------- 382 Aspergillus ter...
XP_001401251 315 TMVTYLLHT-GFTPLQVSGMRIGAVIAELSGTWAAPFITGRIGPIRSGLWFLNWQFACLAAAVAAFAFLDNQ-------- 385
XP_001274573 318 TMVTFLLHT-EYTSLQVSCMRVGSVIAELSGTWVAPFVMDKVGPIRSGLWFLNWQFTCLSAVAAAFALTDAT-------- 388
XP_003966250 341 ITTGYAYTQ-GISGSLLSLLMGVSAITGLMGTVMFTRLRKSYGLVNTGIISSCLHLGCLLLCVCSVFAPGSPmdlsllvp 419
Q9I9R3       321 ITTGYAYTQ-GLNGSVLSLLMGASAVSGICGTVAFTWIRKKCGLIRTGFIAGVTQLSCLTLCVASVFAPGSPfdlsvspf 399 zebrafish
Q8IA95       259 LAASYGQKH-GLSASYIGVLRGFGSALGVIGTFSFQFVAKRFGLLWTVMIGLVWQNIFIEMCGVSVLLPGSSmdvsgyia 337 Caenorhabditis ...
6W4S_F       406 edirsrfiqgesitptkip------------eitteiymsngsnsanivpetspesvPIISVSLLFAGVIAARIGLWSFD 473 human
Q8W4E7       489 ---------------------------------------------------------HKSPLFFFLSMIVLSRLGHMSYG 511 thale cress
KIS70817     471 ----------------------------------------------------sdkrrSNWNTGLLFSGLALSRIGLWAFD 498
Q5AXY5       361 ---------------------------------------------------------PRLVAGCLITGVALSRLGLWGFD 383 Aspergillus nid...
Q0CWF0       383 ---------------------------------------------------------SQVVAVSLIVGVALSRIGLWGFD 405 Aspergillus ter...
XP_001401251 386 ---------------------------------------------------------SQVVAVSLIVGVALSRIGLWGFD 408
XP_001274573 389 ---------------------------------------------------------SRLVLVGLIVGVALSRVGLWGFH 411
XP_003966250 420 finssspelgdivsqrkkhayplrggsnqpllpdrssihwtnntllfdnvpsdtvpeSYISIILLFLGVITARIGLWSFD 499
Q9I9R3       400 eevlrhlfgdsgslres---------------ptfiptteppiqanvtvfeeappveSYMSVGLLFAGVIAARVGLWSFD 464 zebrafish
Q8IA95       338 ntsvsewskev---------------------------lsrvsnpepqnvpsvsfydVALPVNLFFIGISFARFGLWLAD 390 Caenorhabditis ...
6W4S_F       474 LTVTQLLQE-------NVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFV 531 human
Q8W4E7       512 VVGAQILQT-------GIPSSKANLIGATEISVASLAESLMLGVAIAANDASHFGFLAVLSLLSV 569 thale cress
KIS70817     499 LTQLAMIQTalspeqlGPDAGRKNALMALQFSLQNVFDLGHYGLTLGWNKPQEFKYAATVSLVAV 563
Q5AXY5       384 LSVQFLVQE-------NIDPSSRARFSATEMALQSVFEMISFATTIFFADPDQFKYPVYISYGAI 441 Aspergillus nidulans
Q0CWF0       406 LSVQFLIQD-------GIAEHERARFSSTEMALQNIFELLSFATTIVFSRPEQFKYPVFISYGAI 463 Aspergillus terreus NIH2624
XP_001401251 409 LSVQFLVQE-------GVDERARARFSSTEMALQNIFELLSFATTIAFPLPEQFKYPVFISYGGI 466
XP_001274573 412 LSAQFLIQE-------GVEEETRGQFSSTEMAVQNIFEMLSFATTIAFPLPEQFKYPVFISYGAI 469
XP_003966250 500 LTVTQLLQE-------SICESERGVVNGVQSSMNYLMDLLHFIMVISAPQPQHFGILVIISVLFI 557
Q9I9R3       465 LTVTQLIQE-------NVIESERGVINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVIISVSFV 522 zebrafish
Q8IA95       391 PAITQIQQE-------TIPESQRYMAFTVQIALNEVFSILKDIIVIMFPFTPLFGVLTLGSCVFV 448 Caenorhabditis elegans
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