Conserved Protein Domain Family
Tissue_fac
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pfam01108: Tissue_fac 
Tissue factor
This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.
Links
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Statistics
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PSSM-Id: 460067
Aligned: 30 rows
Threshold Bit Score: 91.2916
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q969J5   7 FLGFLISFFLTGvaGTQSTHESLKPQ------RVQFQSRNFHNILQWQPGRALTgNSSVYFVQYKimfscsMKSSHqkps 80  human
Q2PBB8   5 LRGALWGCL-----LLCVSGIVPKPR------NARISSVNFRSVLLWDP-PGVRkGNLSYTVQAKs-----IFPKQ---- 63  chicken
Q9JLU8  17 VPTLLLGWVLVQvaGAEGIP--VKPY------NLTWKSTNFKTILEWEP---KP-INNVYTVQIS-------TALE---- 73  domestic guinea pig
Q7ZT22   2 KRVALIVLVLDC--VHAVLASYPRAY------NVTWKSTNFKTVLTWEP---KPsADYSYTVEFF-------RAGQ---- 59  spotted green pufferfish
P20352  13 LAPTFLGCLLLQviAGAGIPE--KAF------NLTWISTDFKTILEWQP---KP-TNYTYTVQIS-------DRSR---- 69  house mouse
P24055  17 PYTVLLGWLLAQvaRAADTTG--RAY------NLTWKSTNFKTILEWEP---KS-IDHVYTVQIS-------TRLE---- 73  rabbit
P13726  17 ARTLLLGWVFAQvaGASGTTNTVAAY------NLTWKSTNFKTILEWEP---KP-VNQVYTVQIS-------TKSG---- 75  human
P30931  17 ARALLFGLVLIQgaGVAGTTDVVVAY------NITWKSTNFKTILEWEP---KP-INHVYTVQIS-------PRLG---- 75  cattle
A0FJH7   3 TSSSYTGRLFLIhlYFTVIYAIPAPV------NFTIWSHNFRHILHWNYGVNSP-PQSVFNLQRF-------EKGK---- 64  zebrafish
P48551   8 FIFRSLNLVLMVyiSLVFGISYDSPDytdescTFKISLRNFRSILSWELKNHSI-VPTHYTLLYTi-----MSKPE---- 77  human

Q969J5  81 gcwqhiscnfpgcrtlakygqrQWKNKEDCWGTQELSCDLTSETSD-IQEPYYGRVRAASAGSYSEW 146 human
Q2PBB8  64 ----------------------NFNNV--TTNLNVTECDVSSLS---VYGAYVLRVRTEWEDEHSDW 103 chicken
Q9JLU8  74 ----------------------DWKSI--CFSITATECDLTSEMAPnVQQTYLARVISLLPNSTGFL 116 domestic guinea pig
Q7ZT22  60 ----------------------DRRRSPLCVRSSATQCDLSGALSS-LTSSYTADVLSEPPLGEPSE 103 spotted green pufferfish
P20352  70 ----------------------NWKNK--CFSTTDTECDLTDEIVKdVTWAYEAKVLSVPRR--NSV 110 house mouse
P24055  74 ----------------------NWKSK--CFLTAETECDLTDEVVKdVGQTYMARVLSYPARNGNTT 116 rabbit
P13726  76 ----------------------DWKSK--CFYTTDTECDLTDEIVKdVKQTYLARVFSYPAGNVEST 118 human
P30931  76 ----------------------NWKNK--CFYTTNTECDVTDEIVKnVRETYLARVLSYPADTSSST 118 cattle
A0FJH7  65 ----------------------QTEHL----NIRNTTMDVSEACQD-IYIPCTFLIWASLDNMNSSV 104 zebrafish
P48551  78 ----------------------DLKVVKNCANTTRSFCDLTDEWRS-THEAYVTVLEGFSGNTTLFS 121 human
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