Conserved Protein Domain Family
ARA70

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pfam12489: ARA70 
Nuclear coactivator
This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.
Statistics
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PSSM-Id: 463604
Aligned: 30 rows
Threshold Bit Score: 87.4847
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPQ18234     210 VPLSEWLL----GSKPTNG-HPAPYTPSTNLQDWLTQKQTFESs-qTSSRTCSVFSNVWGNLKGLENWLHKSQQEvVPEK 283
XP_001638385   9 YVLEDVRAkislLEKAIDEvGSV-------------KKSLKISaadVKAQIRDNISRHLEALRNRETWLLSQVEVlQHGK 75 
XP_003230765  15 EPLDKCLRakkdLETAIAGiVKA-------------EQQVKDNwreVKAQIHSCISRHLECLRSREVWLLEQVDLiQQLK 81 
Q1RMQ8        15 EPLLRCCDarrdLELAIGGvLRA-------------EQQIKDNlreVKAQIHSCISRHLECLRSREVWLYEQVDLiYQLK 81  cattle
CAG05121      22 GTLMMCQQaqdqLQNAINTvVRA-------------EQQLRENtreVRLQLQSCVSRQQEALRCREVCLLGQIELiEQLK 88 
XP_023183213   9 SSMKLCQEaqdqLEDAIGSvLKA-------------EQQLRDNtreVRSELQSCMSRQQEALRCREVWLLGQIELlESLK 75 
Q6P0F7        10 AALRQCIQaraqLDEAIADiIKA-------------EVQLKSNsreVKSQLHSCISRHLEILRSREVWLLEQIDLvEQLK 76  zebrafish
Q6P0F7       187 TPLTEWLL----GNHPVCS-APVKYHFSTNPHDWLLVSKESQE---EKQLPAFDFQKAWGQLHDLESWLLKEKLP-IRKR 257 zebrafish
XP_031458335  15 ETLAKCLQarkdLETAISGiVKA-------------EQQIKENwreVKAKIHSHISRQLECLRSREVWLFEQVDLiQQLK 81  Ring-necked phe...
XP_007247448 201 VPLAQWLF----GSRPVAS-APVGYQSSKNPQDWLLAPKEKPQv--YRPLVQFDFQKAWGQLKDLEVWLLKEKSP-LRER 272
EPQ18234     284 pn--yEKGNSCS---TTSSCSIDTDKVEDPELLDQDE--M-----------SLSDWLLTDQDSPKLEKPGngsceTSEKF 345
XP_001638385  76 edvlrLQHAELNqavGTLKHALALLHKSDGKSEHIEE--Qlmh-----tiqAMEKFSLQPEESGFISFRA-----LNMEL 143
XP_003230765  82 eealqQQAQQLFwllGQFNCLIHQLEQPHS--NDLAN--Qisv-----cleRLGNLALNPEETSILNFEA-----DVPFL 147
Q1RMQ8        82 eetlqQQVQQLYwllGQFNCLIHQLECTQN--KDLAN--Qvsa-----cleRLGSLTLKPEDSTALLFEA-----DITAL 147 cattle
CAG05121      89 tetlqQQLHQLHwlrGQFDVIAHQLQNNNNNSNDLSN--Qltc-----cleKLSSLNMTPEETPDLHFLA-----DSRSL 156
XP_023183213  76 tetlqHQLHQLHrlrGQFEVIAHQLQNSNNN-NDLSN--Qlts-----cmeKLASLSLAPEETPEMRFHA-----DSRSL 142
Q6P0F7        77 getlhQQLQQLHslkGQFDLLIHQLEYSGS--NSLTT--Qltn-----cleKLSSLNLTPEETPEMSFQA-----DAHTL 142 zebrafish
Q6P0F7       258 ---------TCS---SSSTFSIEMIDESDFNLDDVED--EqekasdtfeeeELNKWLVNSSLVKPNQTNP-----DAERF 318 zebrafish
XP_031458335  82 eealqQQAQQLYwylGQFNCLIHQLEHSYN--NELAN--Qisv-----cleRLESLTLKPEESSVLNFEA-----DTSYL 147 Ring-necked phe...
XP_007247448 273 -----ANSSASS---SSSAFSIEKIDESDFLDMEEEDgvQtenneeiadteVLSDWLITPNTSNTMTNPLs----DADRW 340
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