2F69,3CBM,1MT6,1MUF,1N6A,1O9S,1XQH,1H3I,3M54,3VUZ,4E47,4J7F,5AYF,5EG2,1H3I,4JLG


Conserved Protein Domain Family
SET_SETD7

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cd10530: SET_SETD7 
SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins
SETD7 (EC 2.1.1.43; also termed histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, lysine N-methyltransferase 7 (KMT7) or SET7/9) is a histone-lysine N-methyltransferase that specifically monomethylates 'Lys-4' of histone H3. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Set7/9 also methylates non-histone proteins, including estrogen receptor alpha (ERa), suggesting it has a role in diverse biological processes. ERa methylation by Set7/9 stabilizes ERa and activates its transcriptional activities, which are involved in the carcinogenesis of breast cancer. In a high-throughput screen, treatment of human breast cancer cells (MCF7 cells) with cyproheptadine, a Set7/9 inhibitor, decreased the expression and transcriptional activity of ERa, thereby inhibiting estrogen-dependent cell growth.
Statistics
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PSSM-Id: 380928
Aligned: 32 rows
Threshold Bit Score: 231.419
Created: 28-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2F69; Homo sapiens SETD7 binds AdoHcy and a TAF10 peptide, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #             ###                #      #  ## # #  ######  #  #  
2F69_A       103 PDPYESERVYVAESLIs-----------SAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVID 171 human
NP_001002456 208 PDPYESQRVYVGQSLIs-----------GAGEGLFAQTEAEANTVMAFYNGVRITHTEVDSRDWSMNGNTISLDEDTVID 276 zebrafish
EAL63344     253 IDLYERFHCFVGKQSTi----------pNSGEGLFAKIFIPSGTIISFYNGIRLTHQLVNSRSWSENNNTISLNHETVID 322 Dictyostelium d...
Q7Z0G7       216 PDPYESELVYAAPSKIp-----------NAGEGLYAKCDVDQDTVMAFYNGVRLKQDEVENRDWSQNSNTISLTDDIAID 284 Halocynthia ror...
XP_001742975 261 PDPLEQAMVNVRPSLLp-----------ASGEGLFTSKPATAGTIVAFYSGVRVAQDEVDQRDWDETDYTLSVDDDCCVD 329 Monosiga brevic...
XP_002112735 197 SDPYEQKRVYVAKSLIp-----------GAGEGLFSKIFAEKDQVMSFYNGIRITHQEVDDRSWIFNDNTISLDETTVID 265 Trichoplax adha...
XP_002608672 207 PDPYEQQMVYVGASTIq-----------GASEGLFMKVPVKEDKVVAFYNGLRLTHAEVDARDWAKNGNTISLDEEIVID 275 Florida lancelet
EKX55321     254 PDPYEAERCRVGTSSLcgtkdegvaggnEAGEGLFLRTSAQEGELLSFYNGIRYPHAVVDKRAWKMNGNCISLDEEFAID 333 Guillardia thet...
KJE93610     358 PDPHESILVYVAPSTVp-----------GAGEGLFARVDIAPRTVVSFYHGVRVSHAEVDARDWSANSNTISLDDTVVID 426 Capsaspora owcz...
XP_011402540 217 PDAYEQSKVYVSTCSDn----------pDKGEGLFAKTELAEGETVSFYNGLRLTHDEVDSRDWSLNANTITLDESMVLD 286 Amphimedon quee...
Feature 1                         #####        #           #                  ###
2F69_A       172 VPepyn-hvskYCASLGHKANHSFt-PNCIYDMFVHPRFGPIKCIRTLRAVEA-DEELTVAYGY 232 human
NP_001002456 277 VPapfn-mtenYCGSLGHKANHSFs-PNCKYDQYVHPRFGQIKCIRTIRAVEK-DEELTVAYGY 337 zebrafish
EAL63344     323 VPphlndtvtqYSATISHKANHLVpaNNSVYASFYHPRFGDIKCIKAIKDINE-NEEIFVDYGY 385 Dictyostelium discoideum AX4
Q7Z0G7       285 VPeeyv-stdnYCASLGHKVNHSFd-PNCRYDIYQHPRFGFIKCVRTIRGVSE-GDELTVHYTY 345 Halocynthia roretzi
XP_001742975 330 VPpvyr-slgiYCATLGHKANHSFdqQNAQYEPCWHPRFGPIKCLRLLKDLAA-GEEVYVHYDY 391 Monosiga brevicollis MX1
XP_002112735 266 VPvnsa-nvnnYCASLGHKANHSFt-PNCKYDLYYHPRFGNIKCIRSISDVAP-NEELTVDYGY 326 Trichoplax adhaerens
XP_002608672 276 VPppfd-dtkhYRASLGHKVNHSFc-PNSKYDLFQHPRFGFIKCIRTIKPVSA-DEELTVEYGY 336 Florida lancelet
EKX55321     334 VPpehs-sidrYCASLGHKANHSFq-PNAEYAPCFHPRFGHIKCIRALRRMEA-GEEVLVHYGY 394 Guillardia theta CCMP2712
KJE93610     427 VPvpfd-nvnsYCATLGHKANHHFqlKNAEYGLFTHPRFGLIKCVQALDRAIPaGSEIFVSYDY 489 Capsaspora owczarzaki ATCC 30864
XP_011402540 287 VPlkys-sldaYVASLGHKANHSSa-PNCEYDHFVHPRFGHIKCIRTIKEVSK-GNELTCDYGY 347 Amphimedon queenslandica

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