1G3N,1BI8,1XO2


Conserved Protein Domain Family
STKc_CDK6

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cd07862: STKc_CDK6 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270846
Aligned: 5 rows
Threshold Bit Score: 571.591
Created: 24-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ######  #             # #                                 #             
1G3N_A        11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR 90  human
1BI8_A        11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR 90  human
1XO2_B        11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR 90  human
NP_001007893  11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR 90  chicken
XP_001345361   8 QQYEPVAEIGEGAYGKVYKARDLKNGGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLESFEHPNVVRLFDVCTVSRTDR 87  zebrafish
Feature 1               ####  #                                            ## #          #       
1G3N_A        91 ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY 170 human
1BI8_A        91 ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY 170 human
1XO2_B        91 ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY 170 human
NP_001007893  91 ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMLQLFRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY 170 chicken
XP_001345361  88 ETKLTLVFEHVDQDLTTYLEKAPDPGVPPETIKDMMYQLLQGLDFLHSHRVVHRDLKPQNILVTSGGQIKLADFGLARIY 167 zebrafish
Feature 1                                                                                        
1G3N_A       171 SFQMA-LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 human
1BI8_A       171 SFQMA-LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 human
1XO2_B       171 SFQMA-LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 human
NP_001007893 171 SFQMA-LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGNSDVDQLGKIFDVIGLPEEEDWPNDVAL 249 chicken
XP_001345361 168 SFQMAlTSVVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRRPLFRGNSDVDQLGKIFDVVGVPSPEDWPQEVGL 247 zebrafish
Feature 1                                                               
1G3N_A       250 PrQAFHSKSAQPIEKFVTDiDELGKDLLLKCLTF----NPAKRISAYSALSHPYF 300 human
1BI8_A       250 PrQAFHSKSAQPIEKFVTDiDELGKDLLLKCLTF----NPAKRISAYSALSHPYF 300 human
1XO2_B       250 PrQAFHSKSAQPIEKFVTDiDELGKDLLLKCLTF----NPAKRISAYSALSHPYF 300 human
NP_001007893 250 PrNAFASRPAQPIEKFVPDiDDMGKDLLLKCLAF----NPAKRISAYAALSHPYF 300 chicken
XP_001345361 248 PqSAFSPRPAQPIENLVPDmDELGKSLLLSLDSTskslYAQPFPSKKPSLEERAA 302 zebrafish

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