1XBR,6F59,6F58


Conserved Protein Domain Family
T-box_TBXT

?
cd20202: T-box_TBXT 
Click on image for an interactive view with Cn3D
DNA-binding domain of T-box transcription factor T and related T-box proteins
TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.
Statistics
?
PSSM-Id: 410328
Aligned: 7 rows
Threshold Bit Score: 401.725
Created: 8-Mar-2019
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
DNA bindinghomodimer
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Xenopus TBXT monomers dimerize upon DNA binding forming a loose dimer
  • Structure:1XBR; Xenopus TBXT monomer binds DNA, contacts at 4A
  • Citation:PMID 9349824

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                 #  ##                                #                 
1XBR_A         1 ELKVSLEERDLWTRFKELTNEMIVTKNGRRMFPVLKVSMSGLDPNAMYTVLLDFVAADNHRWKYVNGEWVPGGKPEPQAP 80  African clawed ...
6F59_A         3 ELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAP 82  human
6F58_A         3 ELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAP 82  human
P79777        39 ELRVALEDGELWLRFKELTNEMIVTKNGRRMFPVLKVSVSGLDPNAMYSFLLDFVAADGHRWKYVNGEWVPGGKPEPQAP 118 chicken
XP_005993410  41 ELKVTLEENELWHKFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAP 120 coelacanth
XP_007892513  40 ELKVNLEDVDLWLKFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFVLDFVAADNHRWKYVNGEWVPGGKPEPQAP 119 elephant shark
Q07998        34 DIKLSLEDAELWTKFKELTNEMIVTKTGRRMFPVLRASVTGLDPNAMYSVLLDFVAADNNRWKYVNGEWVPGGKPEPQSP 113 zebrafish
Feature 1                                  #  #           ##                                # #  
1XBR_A        81 SCVYIHPDSPNFGAHWMKDPVSFSKVKLTNKMNGGGQIMLNSLHKYEPRIHIVRVGGTQRMITSHSFPETQFIAVTAYQN 160 African clawed ...
6F59_A        83 SCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGDPQRMITSHCFPETQFIAVTAYQN 162 human
6F58_A        83 SCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQN 162 human
P79777       119 SCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHSFPETQFTAVTAYQN 198 chicken
XP_005993410 121 SCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHSFPETQFIAVTAYQN 200 coelacanth
XP_007892513 120 SCVYIHPDSPNFGAHWMKVPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMISSHSFPETQFIAVTAYQN 199 elephant shark
Q07998       114 SCVYIHPDSPNFGAHWMKAPVSFSKVKLSNKLNGGGQIMLNSLHKYEPRIHIVKVGGIQKMISSQSFPETQFIAVTAYQN 193 zebrafish
Feature 1           #  ##  ### ###  
1XBR_A       161 EEITALKIKHNPFAKAFLD 179 African clawed frog
6F59_A       163 EEITALKIKYNPFAKAFLD 181 human
6F58_A       163 EEITALKIKYNPFAKAFLD 181 human
P79777       199 EEITALKIKYNPFAKAFLD 217 chicken
XP_005993410 201 EEITALKIKYNPFAKAFLD 219 coelacanth
XP_007892513 200 EEITALKIKYNPFAKAFLD 218 elephant shark
Q07998       194 EEITALKIKHNPFAKAFLD 212 zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap