2E6O


Conserved Protein Domain Family
HMG-box_HBP1
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cd21988: HMG-box_HBP1 
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high mobility group (HMG)-box found in HMG box-containing protein 1 (HBP1) and similar proteins
HBP1, also called HMG box transcription factor 1, or high mobility group box transcription factor 1, is a transcriptional repressor that binds to the promoter region of target genes. It plays a role in the regulation of the cell cycle and the Wnt pathway. HBP1 binds preferentially to the sequence 5'-TTCATTCATTCA-3'.
Links
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Statistics
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PSSM-Id: 438804
Aligned: 16 rows
Threshold Bit Score: 135.666
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative DNA
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## #####  ##      #           ##  #  ##      #   #  #   #  #         
2E6O_A        19 KRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKnEERRMYTLEAKALAEEQKRLNPDCWK 87  human
XP_006006054 460 KRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKnEERRVYTMEAKALAEEQKRLNPDCWK 528 coelacanth
AAH95740     402 KRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDKWKKMKnEERRMYTMEAKALAEEQKRLNPDCWK 470 zebrafish
XP_002739523 480 KRPMNAFMLFAKKFRVEYTQLYPGKDNRAISVILGDRWKKMKvEERRVFAQEAKVLAEEHKKIHPDCWK 548 Saccoglossus kowalevskii
XP_013412361 496 KRPMNAFMLFAKKYRVEYTQMYPGKDNRAISCLLGERWKKLKsEERKAFSLEAKMLADQHKKIHPDCWK 564 Lingula anatina
AIA23794     295 KRPMNSFMLFAKKYRLELTRLHPGRDNRDISVLLGEKWRSLSsEEKKVYAREAQSLADLHKRSHPDCWK 363 sea walnut
RDD43804     330 KRPMNAFMLFAKKYRVEITQAHPGKDNRAISVILGDKWKSMEtTERQQYAEKARILAEEHKKNFPDCWK 398 Trichoplax sp. H2
PNF35902     371 KRPMNAFMLFAKKYRLELIQLHPGKDNRAISVILGEAWRNLPaVDKEAYVTEARIMAQERKRLHPDCWK 439 Cryptotermes secundus
XP_020602091 232 KRPMNAFMLFAKRFRVEITQAHPGKDNRAISVILGDKWKAMKqEDRREYVIQAKLLADEHKRVNPDCWK 300 Orbicella faveolata
XP_030828308 430 KRPMNAFMLFAKKFRLEYTQQHPDKDNRAISVILGTKWKKMRlEERRVFSQEAKHLADEHKKIHPDCWK 498 purple sea urchin

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