Conserved Protein Domain Family
BAF250_C

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pfam12031: BAF250_C 
SWI/SNF-like complex subunit BAF250/Osa
This entry represents the mammalian BAF250a/b and its homolog osa from fruit flies. They are part of the SWI/SNF-like ATP-dependent chromatin remodelling complex that regulates gene expression through regulating nucleosome remodelling. In humans there are two BAF250 isoforms, BAF250a/ARID1a and BAF250b/ARID1b. BAF250a/b may be E3 ubiquitin ligases that target histone H2B.
Statistics
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PSSM-Id: 463439
Aligned: 17 rows
Threshold Bit Score: 335.069
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5RGW7       1532 ELAKRCICVSNIIRGLSFVPGNDNELARHPGLVLILGKLVLLHHEHPKRKR-------MPATY---QRE----------- 1590 zebrafish
3_pfamImport    1 DLAQRALALSNILRGFSFVPGSDLMMAKNEALLYIIGRFLRLNVTERKISSkrpvvvlDAEEL---KKEikkvsadekkv 77  
EDO30702      286 AISRRCICVSNILRGLSFVPGNDIEMHRHAGLLLILGRLLLLYHEHAHRVP-------YKRTYlqvDEEpdv-------- 350 
EKC20059     2247 ELGRRCVCISNIFRSLSSIPSNHLELSKHPGLMYTLGKLLMLNHRHLPRNT-------TRRKF---DRD----------- 2305
EFX70974     1490 ALARRALALSNIFRSLSFVPSNETELAKNSTLLVIVGKILLLHHDHPLRSS-------HQKNY---DRE----------- 1548
EDX15823      227 SLARRCIALSNIFRNLTFVPGNETVLAKSTRFLAVLGRLLLLNHEHLRRTP-------KTRNY---DRE----------- 285 
EFA11411     1628 NIGKRCVCISNILRSLTFIPGNESEFSRSSTFLAIVGKLLLLHHEHPPRTQ-------KTRNY---DRE----------- 1686
XP_001946583 1720 SIGKRCVCISNILRNLSFVPGNELEFAKSGPFLGLVGKLLLTHHEHPLRSS-------KTRNY---DKA----------- 1778
EGT37977     1278 ELSHRALALSNILRGFSFVPGSDALMARNEALLFIIGRFMRLNVIERKISSkrpgvvlDSEEL---KKEpkpltagekqa 1354
XP_003112070 1236 DLAHRALALSNILRGFSFVPGSDHLMAKNEALLFIIGRFMRLNVNERKISTkrpgavlNLEEL---KKDpksltedekra 1312
Q5RGW7       1591 --EE------Rgla------------csKDEWWWDCLGALRENTLVTLANISGQLDLSVYPESICLPILDGLLHWMVCPS 1650 zebrafish
3_pfamImport   78 rdKAvlddvdA-----------------TATQMIDTTNQLRDDAFVMLTHMSVSLNIYDLPDSIAFPIYDGLLRWAVSRV 140 
EDO30702      351 pvDD------------------------RDDWWWHCLEVLRENALVILSNIAGQLDLTFYSDTIRASVLEGLLHWLVCES 406 
EKC20059     2306 --DSe----lEdisdg-------hltqcDEEWWWEYFSMLRENTLVIFANICGHLELKYYPEEICMPILDGLLHWAVCPS 2372
EFX70974     1549 --EDv----dFasvdslga-sgsasskcETDWWWDTLLALRENVLVLMANIAGQLDLSIYSEEIVRPVIDGLLHWAICPS 1621
EDX15823      286 --EDt----dFsdscs--------slqgEREWWWDYLITIRENMLVAMANIAGHLELSRYDELIARPLIDGLLHWAVCPS 351 
EFA11411     1687 --EDa----dFadscs--------slqgESEWWWDFLIQIRENILVSIANISGQIDFNVYPEEIVRPILDGLLHWAICPS 1752
XP_001946583 1779 --DDdt---eSlfncttttdadtiepgnDAKWWWDYLDVVRENLLVSLANIAGYVDLSTFNEDISRPILDGLLHWAICPA 1853
EGT37977     1355 keKSvldevdA-----------------TTAQMVETANQLRDDAFVMLTHMSVSLNLFDLPDAIAYPIYDGLLRWSVSRV 1417
XP_003112070 1313 keRSildeadV-----------------TTAQMVETANTLRDDAFVMLTHMSVSLNLYELPDAIAYPIYDGLLRWAVSRV 1375
Q5RGW7       1651 AEAQDPFCTan--gfSSLTPQRLVLECLCKLSIQDSNVDLLLATPPFGRQERLFATLVRHVGDRKSQVCREMAVAVLSNL 1728 zebrafish
3_pfamImport  141 PEATDSTTP------APVSPRDYALEIMCKLVVIERNVDMLLSTGSWSRIEQFVHILSRLLTMNEETHFREFAIVILNAF 214 
EDO30702      407 ADALDPMPTat--psTSLSAQQLVLEALAKMSILGGNAELIISTSSSPQLVLIHDTLVRLLGSRGNPVCRELTLVLLSNL 484 
EKC20059     2373 SCATDPLPStt---tSVLSPQRLVLEALSKLCIHETNVDLLLATPPFDRIVQLFSILTKLLANKSEPVTLEFALVLLSSL 2449
EFX70974     1622 AQSQDPFSSfgphstSLLSPQRLSLETLSKLMVMDCNMDLILATPPFLRLEKLVHFLTRSLCRTEDQVLREFAVNLLYYL 1701
EDX15823      352 AHGQDPFPScg--pnSVLSPQRLALEALCKLCVTDANVDLVIATPPFSRLEKLCAVLTRHLCRNEDQVLREFSVNLLHYL 429 
EFA11411     1753 ATGQDPFASvg--psSLLSPQRLALESLCKLCVTNNNVDLVIATPPFSRLERLCAVLTKHLCRSEDQVLREFSINLLHYL 1830
XP_001946583 1854 AAGQDPFPS------APLSPQRLALESLCKLCVTDNNVDLVIATPPYSRLEKLANVLTRLLCRTEEQVLREFAVNLLHYL 1927
EGT37977     1418 PEATDSTTP------SPVSPRDYSLEIMCKMVVIERNVDMFLSTGSWSRVEQLIHILSRLLTMNEETHYREFAIVILNAL 1491
XP_003112070 1376 PEATDSTIP------APVSPRDYSLEIMCKMVVIERNVDMFLSTGSWSRVEQFVHILSRLLTMNEETHYREFAIVILNAL 1449
Q5RGW7       1729 AQGDPTAARAVALQKGSVGALISFLEDSVAMAQYQQSPHSLLHMG-HSTQHEPPSINMM 1786 zebrafish
3_pfamImport  215 CVASEAICCICAMETQAISHLILFIDAADQSMHQVMQTLGMNALR-DNPELMGTSVGML 272 
EDO30702      485 SQSDNEFAN-LGDKKQCIAMLLQFIEDAANSINAYSSGSSLAQGGyTSEDFCGTSVDML 542 
EKC20059     2450 VQGDTSCARAVAMQHPSISLLLDFLETAEHKAMTVANHHGINALR-DNPEIMGTSLDML 2507
EFX70974     1702 SAADSGMARLIALHNNSLALLVSFVEQAEANALAVASQHGIQALR-ENPESMGTSLDML 1759
EDX15823      430 AAADSAMARTVALQSPCISYLVAFIEQAEQTALGVANQHGINYLR-ENPDSMGTSLDML 487 
EFA11411     1831 AAADSSMARTVASQTPCVSLLVAFIEQAEQSALGVANQHGIGALR-DNPDSMGTSLDML 1888
XP_001946583 1928 AAADSGMARTIALQSPCVSLLVAFIEQTEQNALSVVNTHGLNALR-DNPDSMGTSLDML 1985
EGT37977     1492 CIASEAVCYICAMETSTIAHLILFIDSADQNMHQVMQAHGMTALR-DNPELMGTSVGML 1549
XP_003112070 1450 CIASEAVCFICAMETTTISNLILFVDSADQNMHQVMQAHGMNALR-DNPELMGTSVGML 1507
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