Conserved Protein Domain Family
ILEI_FAM3C
?
cd13940: ILEI_FAM3C 
Interleukin-like EMT inducer
The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.
Links
?
Statistics
?
PSSM-Id: 260114
Aligned: 23 rows
Threshold Bit Score: 265.286
Created: 14-Feb-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q91VU0        53 PPRYKCGiskACPEKHFAFKMASGAAnVVGPKICLEdNVLMSGVKNNVGRGINIALVNGktGEVIDTKFFDMWG------ 126 house mouse
ACM08846      33 QRPSPCGipkPCPEGDFSCLITSGAAnVVAPKICIEgKMAMGYVEKNVGYGINIAVVNGktGEGMKTAFFNMYD------ 106 Atlantic salmon
NP_001004622  68 VPKAKCGlakPCPADGLAFKMYSGATnIVGPQICFDgKMLIQKETRGNWLGINIAVINEetGEHVKTGSFNMWT------ 141 zebrafish
ACM09795      56 TSHPKCSlskNCPIDHFAFQIRSGAAtVVGPKICFDgNIVMSGVMNNVGPGLNLVLVNGenGKIEKFDYFNMYS------ 129 Atlantic salmon
XP_003458328  70 RSAGVCGtprECPAHEISFYIHSGAAnVVPPAICVQnKLVLGTALNNAGGGINIVILNGktGEVLKTDHYNMYS------ 143 Nile tilapia
XP_003967390  25 EPAGPCEn-kECPSDQISFYMHSGVAnVVPGKICLYnTLILGSTLNNAGVGINIVIVNGktGEVTKTGHFDMYG------ 97  torafugu
XP_004069829  67 KSAGPCSprkECPEDHFSFIVQSGAAnVVAPKICIEnDLVLGTVLNNVGIGINTVLVDGktGKVLKTTYFDTYS------ 140 Japanese medaka
XP_003448455   8 TSVPKCSlsrVCPPNHIALRIRSGAAdIVGPTVCFDgKIIMSHALNNVGPGLNIAVINGetGVVEKSACLNMKT------ 81  Nile tilapia
XP_004084677  53 KRAHKCNlsrDCPPGHFAVSVRSGAGdIVGPHICFNgKIVMNSVLNNVRQGLNIVVVDGekGVVEKCGFLNMDI------ 126 Japanese medaka
XP_003973404  55 SADLKCRlskVCPPDHFAMRLTSGAAdVVGPQICFEgKIIMSHVLNNVGPGLNIAVIDGetGIVEKIGSINMQKgkgkrg 134 torafugu

Q91VU0       127 GDVAPFIEFLKTIQDGTVVLMATYDDGATKLTDEARRLIAELGSTSITSLGFRDNWVFCGGKGIKTkSPFEQHIKNNKEt 206 house mouse
ACM08846     107 GDIEPLVEFLKSIENGSIVLIATYDDPATKLNEEARKLIRELGSSAIQSLGFRDNWVFVGGKGADVaSTLEKHIKNNKDk 186 Atlantic salmon
NP_001004622 142 GKVEELIEFLKSIEDGSFVLITTFDDPYTKLNDEARTLLAELGSAFISKIGFRDNWIFVGGKNTLArVYFEQHMKNDRDt 221 zebrafish
ACM09795     130 GETKAILDFLKTIKPGMIVLVASFDDAATKMTDEIRNIFAGLGSSSIKDVKFRDSWVFAGGAGTEQkSPFEKLAANNQKt 209 Atlantic salmon
XP_003458328 144 GDVKPFIELLKSIERGSIVIMASYDEPSTKLNDELKNLIAELGSSHIHSLGYRDNWVFVGGKGVTGkSTFEKHIKSDSAt 223 Nile tilapia
XP_003967390  98 GEVKPLITFLNSIKDGSIVLMASFDEPATKLDNEAKKLIAELGSKYINSLGFRDNWLFVGAKGASKkDLFEKHTKNDGEk 177 torafugu
XP_004069829 141 GDVKYIIDFLKEMKPGSVILMASFDEPSSKLNDEARNLIAELGSSSIQKLGYRDNWVFVGAKGGLVkSSFEKYIKNDKPn 220 Japanese medaka
XP_003448455  82 GDPKDILAHLKKIKRGMIVLVASFDDVTQKMTNEMREIFSEMGSTLIRSVKRRDSWVFAGRAGTKIkSLFEKQAVNDEKn 161 Nile tilapia
XP_004084677 127 GNREDILAYLKEIKPGRIVLVASFNDVATLLTNEIKETFVGMGSSFITSLKLKDNWVFVGRAATKTkSAFEKQAVNDEKt 206 Japanese medaka
XP_003973404 135 EAEEEVLEYLKEIKPGMIVLVASFGDVTPKLTEEVRGLFAGMGSALVTSVKARDNWVFAGRAGGADrSLYEKTAVNEKKt 214 torafugu

Q91VU0       207 nkyeGWPEVVEMEGCIP 223 house mouse
ACM08846     187 nkydSWPEMIEWQGCLP 203 Atlantic salmon
NP_001004622 222 nkydGWPEMIEMEGRIP 238 zebrafish
ACM09795     210 niygNWPEVVEIAGCFP 226 Atlantic salmon
XP_003458328 224 nkydGWPELIGLEGCVP 240 Nile tilapia
XP_003967390 178 naydGWPEFITLTGCIP 194 torafugu
XP_004069829 221 nkydNWPELIDLQGCFP 237 Japanese medaka
XP_003448455 162 niygGWPEMVEVGGCFP 178 Nile tilapia
XP_004084677 207 nayeTWPNMVEVAGCFP 223 Japanese medaka
XP_003973404 215 nayeGWPGQVEVGGCYP 231 torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap