3RZ2


Conserved Protein Domain Family
PTP-IVa1
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cd18537: PTP-IVa1 
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protein tyrosine phosphatase type IVA 1
Protein tyrosine phosphatase type IVA 1 (PTP-IVa1), also known as protein-tyrosine phosphatase of regenerating liver 1 (PRL-1), stimulates progression from G1 into S phase during mitosis and enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. It may play a role in the development and maintenance of differentiating epithelial tissues. PRL-1 promotes cell growth and migration by activating both the ERK1/2 and RhoA pathways. It is a member of the PTP-IVa/PRL family of small, prenylated phosphatases that are the most oncogenic of all PTPs. PRLs associate with magnesium transporters of the cyclin M (CNNM) family, which results in increased intracellular magnesium levels that promote oncogenic transformation.
Links
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Statistics
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PSSM-Id: 350513
Aligned: 7 rows
Threshold Bit Score: 336.66
Created: 29-Nov-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:3RZ2; Rattus norvegicus PRL-1 with bound SH3-motif peptide, contacts 4A
  • Comment:The interaction of PRL-1 with the SH3 domain of p115 RhoGAP results in activation of ERK1/2
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                      #     ## #  #    #####            
3RZ2_A        21 MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQI 100 Norway rat
NP_001008461   1 MARMNRPAPVEITYKNMRFLITHNPTNATLNKFIEELKKYGVTTVVRVCEATYDTAPVEKEGIQVLDWPFDDGAPPSNQI 80  chicken
NP_001086844   1 MARMNRPAPVEITYKNMRFLITHNPTNATLNKFIEELKKYGVTTLVRVCEATYDTALVEKEGIQVLDWPFDDGAPPSSQI 80  African clawed ...
XP_006010806   1 MARMNRPAPVEITYRNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIKVLDWPFDDGAPPSNQI 80  coelacanth
XP_007892266   1 MARMNRPAPVEITYKNMRFLITHNPTNATLNKFIEELKKYSVTTVVRVCEATYDTSLVEKEGIQFLDWPFDDGAPPSNQI 80  elephant shark
XP_021335279  12 MARMNRPAPVEITYKNMRFLITHNPTNATLHKFIEELKKYGVTTVVRVCEATYDANLVVKEGIQVLDWPFDDGAPPSNQI 91  zebrafish
BAG70128       1 MARMNRPAPVEATYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQI 80  human

Feature 1                                                                                        
3RZ2_A       101 VDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF 180 Norway rat
NP_001008461  81 VDDWLNLLKVKFREEPGCCIAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF 160 chicken
NP_001086844  81 VDDWLNLLKVKFREEPGCCIAVHCVAGLGRAPVLVALALIESGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF 160 African clawed ...
XP_006010806  81 VDDWLNLLKAKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF 160 coelacanth
XP_007892266  81 VDDWLSLLKAKFREEPGCCIAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF 160 elephant shark
XP_021335279  92 VDDWLNLLRVKFREEPGCCIAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLFYLEKYRPKMRLRF 171 zebrafish
BAG70128      81 VDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF 160 human

Feature 1               
3RZ2_A       181 KDSNGHR 187 Norway rat
NP_001008461 161 KDSNGHR 167 chicken
NP_001086844 161 KDSNGHR 167 African clawed frog
XP_006010806 161 KDSNGHR 167 coelacanth
XP_007892266 161 KDSNGHR 167 elephant shark
XP_021335279 172 KDSNGHR 178 zebrafish
BAG70128     161 KDSNGHR 167 human

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