Conserved Protein Domain Family
Ashwin

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pfam15323: Ashwin 
Developmental protein
This family of proteins are found in eukaryotes. These proteins have an important role to play in developmental biology, particularly embryogenesis. It plays an important role in cell survival and axial pattern. It is also thought to be a crucial subunit in the tRNA splicing ligase complex. Proteins in this family are typically between 141 and 232 amino acids in length. There are two conserved sequence motifs: HPE and PQR.
Statistics
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PSSM-Id: 464646
Aligned: 13 rows
Threshold Bit Score: 147.289
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEN67779      14 AVDLIHPEILSKDTLIDILTQRLVLKHHhgDESLDKTHLVEMFYKAVTPKPQRKYRLNRRGRVMTKAQirraklrakttG 93 
XP_003218816  21 DLLLLHPELLSQEFLLLTLEQRNVPVEN--ELKVSKDSLTDLYVQHVIPLPQRELPKTRWGKRMEKQR-----------G 87 
XP_016161565 149 ELLLLHPELLSEEFLRLTLEQKNILVEN--DAKMDKDGLTDLYIQHAIPLPQRDLPKSRWGKMMEKKR-----------Q 215
OCA45902      16 SALLLHPELLSRDFLLLSLERRNIPVED--AFN-DKEKLTKIFVQHAMPLPQRDLPRNRWGRMMESKR-----------G 81 
EDO38705      19 TVSYDHPEILERETLVDVLCTKGIDRQE--INALDKVDLVKLFYKYAAPLPQRAQQLRR--------------------A 76 
XP_005998074  19 SDFLLHPELLSRDFVLLTLQEKKIPIEN--EQVVDKDGLLDLYVQHVIPLPQRELPKSRWGRMMEKRR-----------E 85 
XP_015219884  24 TDLLLHPELLSQDFILLTLYEKKIPVEK--EKEANRDHLTNLYLQHVIPLPQRDLPSSRWGKRMEKIR-----------A 90 
Q32LR5        21 VDLLLHPELLSQEFIQLMLQERNIAVSD--PE--DRDRLTGLYLQHVIPLPQRELPRSRWGKRMEKSR-----------P 85  zebrafish
1_pfamImport   1 VDLLLHPELLSHDFLQLILREKHVSTGE--RE--TRDRLTELYLRHVIPLPQRTLPDSRWGKRMEAIR-----------G 65 
XP_028913106  12 AELLLHPELLSHDFLLLTLEQKNIVVEN--DTKSSKDGLTDLYVQHAIPLPQRDLPKSRWGKMMEKKR-----------E 78 
XP_003794364  13 SELLLHPELLSQEFLLLTLEQKNIAVEN--DVKINKDNLTDLYVQHAIPLPQRDLPKNRWGKMMEKKR-----------E 79 
2_pfamImport   1 THMLLHPELLSREFLLLTLQEKNIIGKE--EIKTSKNDLIALYNRHALPLPQRQLPKSRWGKVVEEKR-----------E 67 
XP_001364134  13 SEMLLHPELLSQEFLLLTLEQKNIVVEE--EIKINKDDLTDFYVQHAIPLPQRELPKSRWGKMMEKKR-----------G 79 
EEN67779      94 QQEvqMNMGLKRSASPT----EPRLKPP-------------------INCVNFQ---RKT--IKLGSSPKsaaasSETnt 145
XP_003218816  88 QQV--TKHDMKSFAAVE----NLRKRPL-------------------IVFDGSS---TSTs-IKVRKTEN-----GTV-- 131
XP_016161565 216 QND--LKSESKSVAAVE----GLRKRPL-------------------IVFDGNS---TSTs-IKVKKTEN-----GAA-- 259
OCA45902      82 EKK---ITTVQKSAGTE----GVRKRPP-------------------IVFDGCS---TSTs-IKVKRTEN-----GDAl- 125
EDO38705      77 KRKppKPSEHQPSASPKdiviGSRKRALtsegplrsklyrpddfskiIINKGPSkqkNKTd-IPMQTSKNdlspmSQDss 155
XP_005998074  86 QQV--GLFVQTKSLATD----GSRKRPL-------------------IVFDGSS---TSTs-IKLKKNEN-----GTA-- 129
XP_015219884  91 LQSpaNRSSQQQGSACD----NSRKRPL-------------------IVFDGSS---TKTs-IKLKKTEA-----GSGa- 137
Q32LR5        86 RLS----SSSTHSSSTD----SGRKRPL-------------------IVFDGSS---TSTgcVKLKKPDS-----SSApv 130 zebrafish
1_pfamImport  66 QRA--AAGHTSHSSRND----HNRKRPP-------------------IVFDGSS---SHSgpLKVKKTEGtslstGTI-- 115
XP_028913106  79 QKE--SKNESKSDVAVG----GLRKRPL-------------------IVFDGSS---TSTs-IKVKKTEN-----GAN-- 122
XP_003794364  80 QHE--IKNETKRSSTVD----GLRKRPL-------------------IVFDGNS---TSTs-IKVKKTEN-----GDN-- 123
2_pfamImport  68 VKNe-LKNEQKSDVSVA----ASRKRPR-------------------IVFDGNS---TSTr-IKVRRTEK-----AAN-- 112
XP_001364134  80 QNE--LKNEHKRNMSVE----SLRKRPL-------------------IVFDGNS---TSTs-IKVRKTEN-----GTN-- 123
EEN67779     146 aaDRLKp----pPASVKLS----KVSSTTDSsNGSSKLKAEPVTLitnPGKkSTAIKLVRSpPTSPTSPVANTGVVKVss 217
XP_003218816 132 --DGLK------LTAGSASapcrRLSVSSDS-LACASVSTDSSDF---KIGtSINESKQNN-IRINNNMASSQKSPPS-- 196
XP_016161565 260 --DRLKp----pPAG-STTntvrRLSVPSNA-STYISASSLSEDA---KLGiRNNEAQQNNiSKTDSSVLTGLKVYPL-- 326
OCA45902     126 --QRLNp----sP----------KESTNSTQnSSPALQLGFTTPNkeaKGAtAANHGQHDSsPVTDTTLI-SPKSAKL-- 186
EDO38705     156 kvTKLKrstpepPKSKPVKlnrrSFTNHPSDgNK---------------------------------------------- 189
XP_005998074 130 --DRLKp----pPSG-NTTnairRLSSLSSNsSSNSIIASPPRDTtvrKEEtKPNRTPVNNnNNSSSTTVHLKSLPPS-- 200
XP_015219884 138 -vDRLKp----pPSG-NLTntirRLSGPSANcSLDDSHRSSANHL-------SGKEEAQNNvATIHRSPTGNGKAPSS-- 202
Q32LR5       131 ttDRLKp----pVSSVSLTnpirKLSGASTNcSSSN----------------FSNRTPVSSsGAIPKSPSNHSNS----- 185 zebrafish
1_pfamImport 116 --DRLKp----pPAS-NLFnpvcKLSGNTP--SSSIHCTPDTANL---------QREANKKnA----------------- 160
XP_028913106 123 --DRLKp----pPSTHTTShplrKLSHPS---SPSVSPSVLPTDV---KVP-TPNGSEQNHdVGTGRSSLANVKSPPS-- 187
XP_003794364 124 --DRLKp----pPQASFTSnafrKLSHSSSSvSPLILSSNLPMNN---KTEhNNNDTKQNHdLMHRKSPLGSVKSPPL-- 192
2_pfamImport 113 --DGLKv----nP------------PNDTKQ-SP----------------------------VLMDSSTVANVKSQPL-- 143
XP_001364134 124 --DRLKp----pPSVGVTNntfrKLPHSNT--SSLILPSTLPTDI---KVE-SNNDTKQNHvLMTSRSTLANVKSPPL-- 189
EEN67779     218 ptsdilqtSATETTEQVTEKRKSTDE--TEVSSEQDLNKKKFKPSKIT--WP 265
XP_003218816 197 --------LPVIGTTVVKLKRAAPKEe-IDASNGLKPSDSKKKIQHVT--WP 237
XP_016161565 327 --------SPIAGTTVVKLKRSVPKEe-SDLPSDLKPSEAKKKIQHVT--WP 367
OCA45902     187 --------QQPIIVSAVKLKRTAPKDe-SDVANDAKPTEAKKKIQHVT--WP 227
EDO38705     190 --------TTHAGTITQQSKHVEVCKsdSDSMDE-DIVEVKTQFQKVAvkWP 232
XP_005998074 201 --------TSSSGTSIVKLKRAAPKGe-TE-MGDLKPTEAKKKIQHVT--WP 240
XP_015219884 203 --------TLPTGGTTIKLKRVAPKEgeSEATGEQKSPEPKKKIQHVT--WP 244
Q32LR5       186 --------SVHSNNATSKLKRTSPSKgePDTAKDIKSPETKKKIQHIT--WP 227 zebrafish
1_pfamImport 161 --------SIHSSKQKTSLKNALLMLhlPSLQGSLTSPEVKKKIQHVT--WP 202
XP_028913106 188 --------SPVGSPAVVKLKRAAPKEe-VESVNDLKPTEAKRKIQHVT--WP 228
XP_003794364 193 --------SPV-GTTPVKLKRAAPKEe-AEAMNNLKPPEAKRKIQHVT--WP 232
2_pfamImport 144 --------SHVEETSVVKLKRIVPREd-AKSVNEFKSSGTKKKIQRIT--WP 184
XP_001364134 190 --------SPVGGTTVVKLKRTAPKEe-AESVSDCKPTEAKRKIQHVT--WP 230
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