2KDB


Conserved Protein Domain Family
Ubl_HERP2
?
cd17119: Ubl_HERP2 
ubiquitin-like (Ubl) domain found in homocysteine-inducible endoplasmic reticulum stress protein HERP2 and similar proteins
HERP2, also termed homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein (HERPUD2), is an endoplasmic reticulum (ER) integral membrane protein containing an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold. It is homologous to HERP1, and could be involved in the unfolded protein response (UPR) pathway. It regulates the ubiquitin ligase HRD1-dependent protein degradation at the ER.
Links
?
Statistics
?
PSSM-Id: 340639
Aligned: 6 rows
Threshold Bit Score: 142.492
Created: 9-Jul-2015
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
key conservedkey conserved
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering); may have other functions, for example for NEDD8 it is involved in the mechanism of protein neddylation
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #                                               
2KDB_A        23 PVTLIIKAPNQKYSDQTISCFLnWTVGKLKTHLSNVYPSKPLTKDQRLVYSGRLLPDHLqLKDILRKQDEYHMVHLV 99  human
AAH45865       9 PVTLVIKAPNQKYDDQTINCFLnWTVEELKKHISNVYPSKPLSKDQRLVYSGRLLQDHLqLRDVLRKQDEYHMVHLV 85  zebrafish
EMP30141       1 PVTLIIKAPNQKYTDQTISCFLdWTVGKLKTHLSKVYPSKPSTKDQRLVYSGRLLPDHLqLKDILRKQDEYHMVHLV 77  green sea turtle
XP_007899081   9 PVTLVIKAPNQKYNDQTISCFLnWTVEKLKSHLSKVYPSRPSTKDQRLVYSGKLLPDHLqLKDIFRKQDEYHMVHLV 85  elephant shark
XP_006012826   9 PVTLVIKAPNQKYDDQTINCFLnWTVEKLKAHLSRVYPSKPSTKDQRLVYSGKLLLDHLlLKDIFRKQDEYHMVHLV 85  coelacanth
Q7ZXQ3        10 PVTLVIKAPNQKYDDQTINCFLdWTVEKLKSHLSKVYPSKPSAKDQRLVYSGKLLLDHLlLKDVLRKQDEYHMVHLV 86  African clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap