5Z3G,2PL3,6DCR,6X4W,6ACA,1OYY,6YHR,7AUD,2WWY,5M5P,5M5P,2XGJ,6ZNQ,4D25,4LJY,4W7S,6AH0,2GXS,5GJU,1HV8,3RRM,3I5X


Conserved Protein Domain Family
DEAD
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pfam00270: DEAD 
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DEAD/DEAH box helicase
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Links
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Statistics
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PSSM-Id: 425570
Aligned: 181 rows
Threshold Bit Score: 66.8822
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5Z3G_Y   66 TSVQARTIPPLLAGRDVLGAAKTGSGKTLAFLIPAIELLhSlkfKPRNGTGIIVITPTRELALQIFGVA---RELME--F 140  Saccharomyces cerev...
O67347   51 NPIQTLFYKEYEGG-NALVSAPTSAGKSLTAFLFLR---------GKEG-IKVFTAPTRSLVYEKASEL---RELFRk-- 114  Aquifex aeolicus
O30265   87 YPFQKEAMIRLMEGRDVVITAPTGFGKTEAFAVPML----W---RALHGGKAMVFYPTKALARDQEEKI---KFYTS--S 154  Archaeoglobus fulgidus
O26592   54 YRHQREALDAIREGMNILITTPTASGKTLAFNLPIMETLt-----LNPDATALYIYPVKALSRDQLGVL---EELES--E 123  Methanothermobacter...
6ZNQ_B   58 YTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIa-----QDETNRALYLFPTKALAQDQKSEL---NEIID--E 127  Bacillus subtilis s...
O06359   60 WSHQAEAAELAYAGRHVVIGTGPASGKSLAYQLLVLNALa-----TDSRARALYLSPTKALGHDQLRAA---HALAA--- 128  Mycobacterium tuber...
Q58969   47 YLHQVKALKYLYNKKDVVVTTSTASGKSEIFRLAIFDNFl-----SNPDDRYLLIYPTRALINNQYEKFsmeNELFY--K 119  Methanocaldococcus ...
O58731   48 YSHQVKALNLLYSGKNVVVSTPTASGKSEIFRLFIFDSFl-----ENPSSTFLLVYPTRALINNQMEKFdneNKVFA--E 120  Pyrococcus horikoshii
Q05549  292 YSHQADAINSLHQGENVIITTSTSSGKSLIYQLAAIDLLl-----KDPESTFMYIFPTKALAQDQKRAF---KVILSkiP 363  Saccharomyces cerev...
O30165   15 YEYQKEAMDNLLEGKSLIIRAPTGAGKTEASLIPFIYGLn-----DYLPPQLIYSLPTRTLVESIGERA---IKYAS--F 84   Archaeoglobus fulgidus

5Z3G_Y  141 -HSqTFgi----vIGGANR-RQEAEKLm--------KG--VNMLIATPGRLLD-HLq----NTKGfvFKNL--KALIIDE 197  Saccharomyces cerev...
O67347  115 ----KVe---------VRT-GEVFELY---------KEikSEVVVATYESLAL-ALrnrasW-----IEEA--RGVVIDE 163  Aquifex aeolicus
O30265  155 -LGlRAvr-----fdGDSG-REERRAV---------LSgkCDIILTNPDMVDY-HLrntpaFRRI--CREL--SFIAVDE 213  Archaeoglobus fulgidus
O26592  124 -LGlKLnp---stYDGDTP-RERRPWI----------RenSRVILTNPHQLHR-ILpwhhqWRRF--YSNL--RYVVIDE 183  Methanothermobacter...
6ZNQ_B  128 -MGiDIks---ftYDGDTS-PAIRQKV---------RKa-GHIVITNPDMLHSaILphhtkWVSL--FENL--KYIVIDE 188  Bacillus subtilis s...
O06359  129 -AVpRLadvaptaYDGDSP--DEVRRF---------ARerSRWLFSNPEMTHLsVLrnharWAVL--LRNL--RFVIVDE 192  Mycobacterium tuber...
Q58969  120 iTNkRVka---eiLTGDVG-LEKRREI---------LKdkPNVLFTTPDMLHYqILknhnnYLWL--LKNL--KLLVVDE 182  Methanocaldococcus ...
O58731  121 iTGmKVka---siLTGDVD-WSERKKI---------VRnkPNVIFTTPDMLHHtILprwleYKWL--LKNL--KLLVVDE 183  Pyrococcus horikoshii
Q05549  364 eLKnAVvd----tYDGDTE-PEERAYI---------RKn-ARVIFTNPDMIHTsILpnhanWRHF--LYHL--KLVVVDE 424  Saccharomyces cerev...
O30165   85 k---KLrv---aiHHGKKAtSSLFEEDiivttidqtAGayLSVPLSMPKRWGN-IF-----------VGGIasALTVFDE 146  Archaeoglobus fulgidus

5Z3G_Y  198 ADRILEIgFEDEMRQIIKIL-------PnEDRQSMLFSATQT-TKVEDL 238  Saccharomyces cerevisiae S288C
O67347  164 IHQLMGS-RGWILEEIITFLl-------dGNYEILGLSATLP--GAEQL 202  Aquifex aeolicus
O30265  214 LHTYTGV-LGSNMHYLVKRLsr------fAEFQIACASATLS--NAAEF 253  Archaeoglobus fulgidus
O26592  184 AHQYRGV-FGSNVALLLRRLrricryyG-SEPQFVLASATLA--NPAEF 228  Methanothermobacter thermautotrophicus str. Delta H
6ZNQ_B  189 LHTYRGV-FGSHVANVIRRLkricrfyG-SDPVFICTSATIA--NPKEL 233  Bacillus subtilis subsp. subtilis str. 168
O06359  193 CHYYRGV-FGSNVAMVLRRLlrlcaryS-AHPTVIFASATTA--SPGAT 237  Mycobacterium tuberculosis
Q58969  183 LHVYRGV-FGTNMVYVFKRLlkllkrlN-NNLQILCLSATL--KNPKEF 227  Methanocaldococcus jannaschii DSM 2661
O58731  184 LHTYRGV-FGSNVAYVFRRVffrlrrlN-SSPLILALSATL--RNPKEF 228  Pyrococcus horikoshii
Q05549  425 LHIYKGL-FGSHVALVMRRLlrlchcfY-ENSGLQFISCSATlKSPVQH 471  Saccharomyces cerevisiae S288C
O30165  147 VHTLDPE-KGLQTAA-AIAMqsaklglP-----SIIMSATLPdVFIERV 188  Archaeoglobus fulgidus
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