6C14


Conserved Protein Domain Family
L_HMGIC_fpl
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pfam10242: L_HMGIC_fpl 
Lipoma HMGIC fusion partner-like protein
This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumour cell lines.
Links
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Statistics
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PSSM-Id: 463019
Aligned: 17 rows
Threshold Bit Score: 168.664
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6C14_B        32 VGVMWGTLTICFSVLVMALFIQPYWIGds---------------vsTPQAGYFGLFSYCVgnvl-sselICKGGPLDFSS 95 
Q568B9         9 RSMLWTLMSIVVAFAELVAFMSAEWLVgysegsel---nftvtashRSDQRTLGIYNRCLkvaq-qkvvQCGPYATDFME 84  zebrafish
Q4S279         9 RSMLWTLLSIVAAFGELIAFMSTDWLVgyprtpdavfgrhgataagEAYRPTLGIYGRCIklphlqrgiLCGPYAIHFGE 88  spotted green p...
Q178A0        25 IAVLWAIFSICYAIISVVAFVTPEWVGds----------------dSDAGGRLGLWQICQkdd---lndSCSGKLEDLLA 85  yellow fever mo...
Q2M056        25 IGVLWAIFTICYAIIGIVAFVTPEWIGdp----------------dNDGAGRLGLWQQCQrde---ifdNCRRRWENVLA 85  Drosophila pseu...
XP_011619172  25 VGVLWAVCTLCFAIIQVVVLVQPSWVGttqg-----------pmglARPSGTLGLFEVCVesdw--pvpDCRGGLSSLSP 91 
Q7TSY2        22 IGVLWAIFTICFAIINVVVFIQPYWVGds---------------vsTPKPGYFGLFHYCVgsglagrelTCRGSFTDFST 86  Norway rat
XP_011612543  22 VGVLWTVFTITFAVITVVVFIQPYWIGds---------------vsTPQAGYFGLFHYCIgnal-tselTCKGSALDFGS 85 
Q5PPI7        25 VGVMWGTLTICFSVLVMALFIQPYWIGds---------------vsTPQAGYFGLFSYCVgnvl-sselICKGGPLDFSS 88  Norway rat
Q7ZZL8        25 MGVLWALFTLCFSILMVVTFIQPYWIGds---------------idTPQAGYFGLFSYCIgnal-tgelICKGSPLDFGT 88  chicken

6C14_B        96 IPSRAFKTAMFFVALAMFL-IiGSIICFSLFFVCN----TATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCge 170
Q568B9        85 IASGFWQATVIFLVIGIFL-L-SVVGILSVFSMCFqsilKKSIFNVCGLLQGIAGLFLILGLMLYPAGWGSKKVVDYCgp 162 zebrafish
Q4S279        89 IASGFWQATSIFLAAGILL-L-CAVAFISVFTMCFqsimKKSIFNVCGLLQGIAGLFLILGLMLYPAGWGSEKVQLYCgq 166 spotted green p...
Q178A0        86 MQSIAFQVATVFCGLAVATsV-LAICCLLLMVFMK----STTVFHICGWMQMLSALCMVIACVSFPFGWNSDEFRKVCgp 160 yellow fever mo...
Q2M056        86 VPTFSFQLATFFMMGAIGLaL-LTIFFLVCLLFMK----STRVFHICGWMQIISALCMIVACAAFPFGWNSDDFRKICgp 160 Drosophila pseu...
XP_011619172  92 LPS--FQSVAVLVGVSLWAvW-TSVLCLCLFRFCS----AATVYKICAWLQLTAGFCLALACLLFPDSWESPEMRSLCge 164
Q7TSY2        87 IPSSAFKAAAFFVLLSMVLiL-GCITCFALFFFCN----TATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCga 161 Norway rat
XP_011612543  86 IPSGAFKTAMFFVGISMLLvV-GSIVCFSLFFFCN----AGSVYKICAWMQLASSTCMVIGCMIYPDGWDSDEVKRMCgq 160
Q5PPI7        89 IPSRAFKTAMFFVALAMFLiI-GSIICFSLFFVCN----TATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCge 163 Norway rat
Q7ZZL8        89 IPSSAFKTAMFFVGISTFLiI-GSILCFSLFFFCN----AATVYKVCAWMQLAAATGLMIGCLIYPDGWDSSEVKRMCgd 163 chicken

6C14_B       171 QTGKYTLGHCTIRWAFMLAIlsigDALILSFLAFVLGYR 209
Q568B9       163 DASAYKVGLCSLGWAFYTAI----GGTVLTFICAMFSAQ 197 zebrafish
Q4S279       167 DAAPYRTGLCSMGWAFYTAM----GGTVLTFICAVFSAQ 201 spotted green pufferfish
Q178A0       161 ESNRFEVGLCGLRWAYPLAIiaciDGFILATLSFILATR 199 yellow fever mosquito
Q2M056       161 EANRFELGLCGIRWAYPLAIigcvDGVVLATLAFILATR 199 Drosophila pseudoobscura
XP_011619172 165 SVGSFSPGNCSVHWAYILAVlgvlDAAILATLAFVLANR 203
Q7TSY2       162 KTGKYSLGDCSVRWAYILAIigilNALILSFLAFVLGNR 200 Norway rat
XP_011612543 161 RTDKYTLGNCTVRWAYILAIisimDSLVLSLVAFSLGSR 199
Q5PPI7       164 QTGKYTLGHCTIRWAFMLAIlsigDALILSFLAFVLGYR 202 Norway rat
Q7ZZL8       164 KTDKYTLGACTVRWAYILCIigilDALILSFLAFVLGNR 202 chicken
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