6DBQ


Conserved Protein Domain Family
RAG2

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pfam03089: RAG2 
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Recombination activating protein 2
V-D-J recombination is the combinatorial process by which the huge range of immunoglobulin and T cell binding specificity is generated from a limited amount of genetic material. This process is synergistically activated by RAG1 and RAG2 in developing lymphocytes. Defects in RAG2 in humans are a cause of severe combined immunodeficiency B cell negative and Omenn syndrome.
Statistics
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PSSM-Id: 427128
Aligned: 11 rows
Threshold Bit Score: 655.653
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6DBQ_B        54 KKGELKLRAISFSNNSSYLPPLRCPAIAHFEAQD---GKPECYLIHGGRTPNNELSSSLYMLSVDSRGcNRKVTLRCEEK 130 zebrafish
XP_017948752  51 KNNELRLRPTIFTNDSCYLPPLRHPAVCSLPASQg--GEITQYLIHGGKTPNNEISHKLYIMAMASSV-NRRFSLCCSEK 127
XP_005986966  51 KHRELKLRPVTFSNESCYLPPLRSSAVTSYLGSGe--SESLQYLIHGGRTPNNELSDKLYLMTLVSKAyNKKVILCCTEK 128
XP_006642507  51 KKGELKLRSVLFSNDSCYLPPLRCPAITHSGPEDlesSDTKKFLIHGGRTPNNELSGCLYIMSLDSRGcNKKVTLKCVEK 130
XP_003440533  51 KRGEMKLRAISFSNDSCYLPPLRCPAVCRLDPYD---GLPESYLIHGGRTPNNEISSSLYLLTMDSRGcNRKLTLRCKEK 127
XP_007228210  51 KRDELKLRAISFSNTSCYLPPLRYPAIARLKPHD---GSPESYLIHGGRTPNNELSSSLYMLSVDSRGcNRKVTLRCLEK 127
XP_003214696  58 KKDELKLKPAYFSKDSCYLPPLRYPAICILKSSAa-qPEKCQYIIHGGKTPNNELSDKLYIISLVSKN-NKKVTFRCTEK 135
EOB07343      51 KQNELKMKPVFFSKDSCYLPPLRYPAICTFRGNEe--SDKHQYIIHGGKTPNNDLSDKIYIMSLVSKT-SKKTTFQCVEK 127
XP_001362290  51 KQNQLKLRPALFSKDSCYLPPLRYPAICTFQDSLe--LKKEQYIIHGGKTPNNELSDKIYIISAICKN-NKKVTFCCTEK 127
P34089        51 KQNHLKLKPAVFSKDSCYLPPLRYPATCTFQGSSe--SEKQQYIIHGGKTPNNELSDKIYVMSVVCKN-NKKVTFRCTER 127 rabbit
XP_001509136  51 KRNQLKLKPATFSKDSCYLPPLRYPATCTLKNSLe--PEKIQYIIHGGKTPNNELSNKIYVMAVACKS-NKKITFCCTEK 127
6DBQ_B       131 ELVGDVPSARYGHTLSVINSRGKTACVLFGGRSYMPPTERTTQNWNSVVDCPPQVYLIDLEFGCCTAHTLPELTDGQSFH 210 zebrafish
XP_017948752 128 DLEGDVPEARYGHSMNVVFSKGKTAVVMFGGRSYVPLNQRTTENWNNVIDCEPLVYLIDLQFGCSTSFNLRELQDGISFH 207
XP_005986966 129 ELEGDVPQARYGHTINMVYSRGKSMCVMFGGRSYMSPGQRTTENWNSIEDCMPQVYLIDLEFGCCTSYNFPELQDGMSFH 208
XP_006642507 131 ELAGDIPEARYGHTMSIVYSRGKRACLLFGGRSYMPPGQRTTENWNSVVDCLPKVFLIDLDFGCCSSYTFPELTDGQSFH 210
XP_003440533 128 ELVAEVPGPRYGHTMSMVQSRGKTACVLFGGRSYMPSGERTTESWNSVVDCPPQVFLFDLEFGCCSAHTLPELSDGQSFH 207
XP_007228210 128 ELVGEPPGPRYGHTISVVHSRGKTACVLFGGRSYMPPTERTTENWNCVVDCPPQVYLIDLEFGCCSAHTLPELTDGQSFH 207
XP_003214696 136 ELIGEVPEARYGHTISEVHSQGKNMMVIIGGRSYMSLGQRTTESWNSVVDCMPDIFLIDLEFGCCTSYTLPDLQSGFSFH 215
EOB07343     128 DLGGDVPEARYGHTINVVHSRGKSMSVIFGGRSYIPLAQRTTEKWNSVVDCLPSVFLVDFEFGCCTSYILPELQDGLSFH 207
XP_001362290 128 ELVGDIPEARYGHTIDVVYSRGKSRCVVFGGRSYMPSAQRTTEKWNSVVDCPPHVFLIDLEFGCCTSYNFPELQDGLSFH 207
P34089       128 DLVGDVPEARYGHSLDVVYSRGKSMGVLFGGRSYMPSNQRTTEKWNSVADCLPHVFLVDFEFGCATSYILPELQDGLSFH 207 rabbit
XP_001509136 128 ELVGDIPEARYGHTIDVVYSRGKSMTVIFGGRSYMPPAQRTTEKWNSVIDCMPHVYLVDFEFGCSTSYVFPELQDGLSFH 207
6DBQ_B       211 VALARQDCVYFLGGHILSSDCRPSRLIRLHVELLLGSPVLTCTILHEGLTITSAIASPIG-YHEYIIFGGYQSETQKRME 289 zebrafish
XP_017948752 208 VSLARNDTVYIFGGHSMGNNFRPPNVYKIKVDLPLGSPAVSCTVIHNKLSFSSSIVTQTS-PDEFVIVGGYESDSQKRFS 286
XP_005986966 209 VSIARNDTVYLLGGHTLESKSRPPRLYRLKVDLLLGSPVVGCSELPGGISVSSAIVAQTG-ANEYVILGGYESETQKRMT 287
XP_006642507 211 VSLSRKDSVYVLGGHTLANNTRPARLFRFRVELLLGSPIVSCEVLNTGISVSSAIVTRVGsSHEYIIMGGYKSESEKRLE 290
XP_003440533 208 LALAREDCVYFIGGHSLASDSRPPRLFRLHVELLQGSPLLSCETLDNGLSISSAIFTRTGpTHRYIILGGYQSDSQKRME 287
XP_007228210 208 LALAREDCVYFLGGHILSTDCRPPRLFRLRVELLLGSPLLSCEVFNEGLSITSAIATSVGsAHEYIILGGYQSESEKRMQ 287
XP_003214696 216 LCLTRNDTLYIIGGHSIQNNTRPPNLYRIKIDLPLGSPAVSCCALPGGISVSSAIVTQTN-NNEFVVIGGYHSDNQKRMV 294
EOB07343     208 VSVARNDTIYILGGHSLQNNTRSPSLYKLKVDLPLGSPALTCSVLPGGISVSSAIVTQTS-DTEFVLVGGYQSDSQKRLV 286
XP_001362290 208 VSIARDDTIYMIGGHSLSNNSRPPNLYRLKVDLPLGSPEVSCTVLPGGISISSAILTQTK-SNEFVIVGGYQFENQKRLV 286
P34089       208 VSIARNDTVYILGGHSLANNIRPANLYRIRVDLPLGSPAINCTVLPGGISVSSAILTQTN-NDEFVIVGGYQLENQKRMV 286 rabbit
XP_001509136 208 VSVARNDTVYILGGHSLTNNSRPPNLFRLKVDLPLGSPAVSCTVLSGGLSVSSAIVTQRN-SSEFVIVGGYQLDNLKRMA 286
6DBQ_B       290 CTYVGLDDVGVHMESREPPQWTSEISHSRTWFGGSLGKGTALVAIPSEGNPTPPE-AYHFYQVSFqk---eQDGEATAQG 365 zebrafish
XP_017948752 287 CNGIFLDDDTIDIQEIETPEWTGEIKHSKTWFGADMGKGAVLFGIPVDNKHQSTDcSFFFYVLNF------GDSDPVVQT 360
XP_005986966 288 CNTAVLDDNSIQVLERESPDWPGDIKLSKTWFGSSMGGGAVFLGIPGENKQITNE-SNYFYRVNL------IEDEEITQT 360
XP_006642507 291 CNTVLLEDSGIHITSREPPEWSGEICHSKTWFGGNMGEGLVLIGVPADGRHNVPE-VHYFYTVNF------RQEEEPGQN 363
XP_003440533 288 CTTVILDEKGIHFEPVETPKWTPDIIHSRTWFGGSSGEGSILLAVPTEGRPSQQD-MHYFYQVNFqte-geTREEDGTLG 365
XP_007228210 288 CTYVALDDVGIRMEPRDPPPWGSEISQSRTWFGGSLEKGNALIIIPSEGNPAPPD-ANYCYQVSFrh---eEDAEDPTQT 363
XP_003214696 295 CNTINLEDNKIEIMEREAPEWTPEIKHCKIWFGSDMGNGAILFGIPGDNRQLTSD-SNYFYILKChge-ddQEAEQMVQV 372
EOB07343     287 CNTIVLEDDKIEIVERASPDWTPDIKHCRMWFGCDMGKGSVLLGIPGANKQLISD-ANYFYILRCkgaeedEEEELTAQI 365
XP_001362290 287 CNIITVEDNKIEIQDMETPDWTPDIKHSKLWFGSSTGNGTVFLGIPGDNRQTLSD-AHYFYLLKCgge-dlMAEEQAAFS 364
P34089       287 CNIVSLEDNKIEIQEMETPDWTPDIKHSKIWFGSNMGNGSVFLGIPGDNKQIVSE-AFYFYMLKCte--ddVHEDQRTFT 363 rabbit
XP_001509136 287 CHIIKLEDNKFEIEEMETPDWTPDIKHSKIWFGSNMGNGAIFLGIPGDNKQAISD-ANYFYILKCgqd-tkEEDDQATYT 364
6DBQ_B       366 GSQEST--DFEDSAPLEDSEELYFGRE 390 zebrafish
XP_017948752 361 CSQGSTe-EQEDSMPLEDSEEFTFNRD 386
XP_005986966 361 CSQESTe-DQDDSTTFEDSEEFYIGCS 386
XP_006642507 364 CSQESTdqELEDSAPLEDSEEFYFNRD 390
XP_003440533 366 CSQEST--DYDDSTPLEDSEELYFGRE 390
XP_007228210 364 CSQEST--DFEDSAPLEDSEELYFGRD 388
XP_003214696 373 CSQSSTe-DAGESTPFEDSEELTFSFD 398
EOB07343     366 CSQASTe-DQGDSTPFEDSEEFCFSAE 391
XP_001362290 365 CSQASTe-DPGDSTPFEDSEEFCFSAE 390
P34089       364 NSQTSTe-DPGDSTPFEDSEEFCFSAE 389 rabbit
XP_001509136 365 CSQTSTe-DPGDSTPFEDSEEFCFSTE 390
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