Conserved Protein Domain Family
7tmA_Opsin5_neuropsin
?
cd15074: 7tmA_Opsin5_neuropsin 
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors
Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.
Links
?
Statistics
?
PSSM-Id: 320202
Aligned: 21 rows
Threshold Bit Score: 332.317
Created: 10-Nov-2008
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
NP_001124215  37 IIAGFYLTVIGILSTLGNGYVIFMSSKRKKkl--rpAEIMTVNLAVCDLGISVVGKPFSIISFFS-HRWIFGwm----gC 109  chicken
EEN50207      39 IVIGVYLLLIGTGSILGNGRVLWLSYRNWAkl--rpVELFVVSLAVTDVGISVFGYPFAASSSLL-GRWSFGsa----gC 111  Florida lancelet
O15974        20 RIIGIFISICCIIGVLGNLLIIIVFAKRRSvr--rpINFFVLNLAVSDLIVALLGYPMTAASAFS-NRWIFDni----gC 92   Yesso scallop
XP_001199309  34 IWAGVYLMFISLIAFIGNISVIVISLRKREkl--kpIDLLTINLAIADFLICVVSYPLPMISAFR-HRWSFGkf----gC 106  purple urchin
XP_001187998  72 LLTALYLTLVGIVSTIGNITVLCVLCRYGTfrk-rsVNILLMNMAVSDLGVSVAGYPLTAISGYR-GRWVFAdi----gC 145  purple urchin
EEA52010     153 LAVAIYLTLLGIVAVGGNVMAIIVFVTEKEfrk-keHNSLLLNMALADLGVSIFGYPASTVSGYA-GRWVLGev----wC 226  Florida lancelet
EEA71384      24 TIMGIYLTVVGLVSTVGNATVVLMFMLKWRqlcrkaPNLLIINLAAVDLCISVFGYPFSASSGFA-NQWLFSda----iC 98   Florida lancelet
XP_001187998 470 LHFPYDDTEGSSIATVGNITVICVLCRYRTfrk-rsINLLLINMAASDLGVSVAGYPLTTVSGYW-GRWLFGdv----gC 543  purple urchin
XP_685121     22 TAIGVYLVILGWLSWIGNGTVILLLTKQRKal--epQDFLTLNLAISDASISIFGYSRGILEVFDvFRDEGYliktfwtC 99   zebrafish
NP_001073125  34 TIIGVYLLILGWLSWFGNSIVIFVLFRQRStl--qpTDYLTLNLAVSDASISVFGYSRGILEIFNiFKDSGYiissvwtC 111  zebrafish

Feature 1          #   ##  ##                                                                    
NP_001124215 110 RWYGWAGFFFGCGSLITMTAVSLDRYLKICHLaYGTWLkRHHAFICLALIWAYATFWATVPFAGVGSYAPEPf------g 183  chicken
EEN50207     112 TWYGFTGFFFGLTSIANMALMSIMRFMIVYKGyPGPYPsRRATSALIAAAWLYGLFWACAPLAGWSQYHVEPf------g 185  Florida lancelet
O15974        93 KIYAFLCFNSGVISIMTHAALSFCRYIIICQYgYRKKItQTTVLRTLFSIWSFAMFWTLSPLFGWSSYVIEVv------p 166  Yesso scallop
XP_001199309 107 VWYGFTSFLFAVGSMATLMVIALLRYAKLCREnVDQYQsRPFVIKVIVAIWGFAFFTTAPPLFGWSSYVPEPy------h 180  purple urchin
XP_001187998 146 QFSGFCVYALSCSTISTHAVVAIYRYIYIVKPyHRPRLsSSTSCLAILCIWTFTLFWTITPFFGWSSYTYEPf------g 219  purple urchin
EEA52010     227 VIYAFVCYTFSMVTMNTLCAISIYRYIVMCTPqYAHLLtHRRTMYVILVTWLYALVFTVPPLVGVNYYTFEPireympgg 306  Florida lancelet
EEA71384      99 TLYGFSCFLLSMVSMCTLCLISIHRYITICRPeHASKLtMTRTILAVVGAWVYGISVAVPPLFGIARYTYESf------g 172  Florida lancelet
XP_001187998 544 QFYAFCVYTLSCSTISTHAAIAVYRYIYIVKTdLRPKLtANFTSGVIVVIWVYAFFWTVTPFVGWSSYIYEPf------g 617  purple urchin
XP_685121    100 KVDGFLILLFGLISINTLTAISVIRYIKGCHPhHAHHInKRNICLVITAVWLFCLFWAGAPLLGWGSYRARGy------- 172  zebrafish
NP_001073125 112 QVDGFFTLVFGLSSINTLTVISITRFIKGCHPhKAHCItNSTVAVCVVFIWIGAFFWSAAPVLGWGSYTDRGy------- 184  zebrafish

Feature 1         ####                 ##   #                                                    
NP_001124215 184 TSCTLDWwlaqasvaGQAFVLSILFFCLLFPTAVIVFSYVKIILKVksstkevah--------ydtriqnshILEMKLTK 255  chicken
EEN50207     186 LSCTVDWgsfsrdagGMSFIICLLVFCVAIPVTAIMASYVAISAIYrqakksiaghl----qdnsamckkrnKLERSITL 261  Florida lancelet
O15974       167 VSCSVNWygh--glgDVSYTISVIVAVYVFPLSIIVFSYGMILQEKvckdsrkngir----aqqrytprfiqDIEQRVTF 240  Yesso scallop
XP_001199309 181 LSCTIDFadt--spsGLSYTYFTTIVVFFMPLMIIVLCYVAIARKMihhnrrin----------vghnagrmLLEIRLLK 248  purple urchin
XP_001187998 220 TSCSINWygk--slgDLTYIICCVVFVFILPIIIMLYCYIGVAKKIkgidplrteerdi-avvfgrlrkhetKIDTRVTK 296  purple urchin
EEA52010     307 IICSLNWnvr--ypgEMAYTVLTIFFGYVVYVVIMGYCYCKIYFKSknlkfgala--------sdkakkavkKDILKASL 376  Florida lancelet
EEA71384     173 LSCTIDFhgt--tvaDMVYLSILIILCYVINVAVMGTCYFKIIRKFskhrfrevr---------dvrtshqhSFERGVTL 241  Florida lancelet
XP_001187998 618 TSCSVNWvgr--tisDISYMVACTIGVYLLQIFIMLYCYIRVAKKIrgvdpgrteekdagvvvfgrlrkreaKIDTHVTK 695  purple urchin
XP_685121    173 GTCEIDWtralysipFKLYVIGIFFFNFFVPLFIIVFAYVSIIRTVnsshkssqg---------gdvserqkKIERSITR 243  zebrafish
NP_001073125 185 GTCEIDWvkanystiHKSYIISIFIFCFLVPVLLMLFCYISIINTVkrgnamnad---------gdlsdrqrKIERDVTI 255  zebrafish

Feature 1                    #   #                      #   #                     
NP_001124215 256 VAMLICAGFLIAWIPYAVVSVWSafgqpdsvPIQFSVVPTLLAKSAAMYNPIIYQVIDckFACCR 320  chicken
EEN50207     262 MALAVCGGFLLAWLPYAVVGLWSavagvdavPLALASAAPLFAKSSSLWNPIIYLGMNdrFSAEL 326  Florida lancelet
O15974       241 ISFLMMAAFMVAWTPYAIMSALAigs--fnvENSFAALPTLFAKASCAYNPFIYAFTNanFRDTV 303  Yesso scallop
XP_001199309 249 TACMITMAYTISWTPYAVIAMWVtyipvnqiPDAFRILPAFCAKTSSVYNPIIYCIFNksFRQDL 313  purple urchin
XP_001187998 297 ICFMMMASFIVVWTPYAVGSIWAski--gkiSASASVLPTMFAKSSCMINPIIFLTSSskFRADL 359  purple urchin
EEA52010     377 MCMTMVVSFLIAWTPYAVSSTWDilte-edlPIIATILPSLFAKSSCMMNPIIYTCCNgkYRQAA 440  Florida lancelet
EEA71384     242 RCILMTLFYLISWTPYTAVAVWTmvg--pppPVQLGMVAALTAKTHCAFNPILYMLMSevYRKLV 304  Florida lancelet
XP_001187998 696 MCFMMMLTFIVVWAPYAVECLRAahv--hriSALSSVLPTMFAKSSCMVNPIIFLTSSskFRQDL 758  purple urchin
XP_685121    244 VSLILCAAFLLAWSPYAVISMWSalg--yqiPTLNGILASLFAKSASFYNPFIYIGMSskFRKDL 306  zebrafish
NP_001073125 256 VSIVICTAFILAWSPYAVVSMWSawg--fhvPNLTSIFTRLFAKSASFYNPLIYFGLSskFRKDV 318  zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap