Conserved Protein Domain Family
NnaC_like
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cd01841: NnaC_like 
NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases. E. coli NnaC appears to be involved in polysaccharide synthesis.
Links
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Statistics
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PSSM-Id: 238879
Aligned: 17 rows
Threshold Bit Score: 151.713
Created: 14-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Citation:PMID 7773790
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                                #                      
NP_345904    32 PNILFIGDSIVEYYPlqelf-------------------------gtsktIVNRGIRGYQtglllenl-dahlyggaVDK 85  Streptococcus pn...
YP_519850    68 ENSVFIGDSLTEGFAfnei----------------------------lpqEQVIAGAGATagfsyddl--dalaekkPDQ 117 Desulfitobacteri...
ZP_01352045 186 NNTIFIGDSRTEGLGqfggvknakfytyrglqvntamkkdyitldnkqkgNVLDAARQTS-----------------FSK 248 Clostridium phyt...
AAO35210    118 KDSIILGDSISEGLSfyev----------------------------ldtNNVIAKKGLTlykaqkev--pnivvknPKK 167 Clostridium teta...
AAN58801     17 DSIVFAGDSITEFFPlkkyl-------------------------ghdlpLVNRGIAGTDsvwllehi-edqvltlsPAK 70  Streptococcus mu...
CAD46830     30 GAIVFTGDSIVEFFPlkkhl-------------------------grdypLVNRGVAGSDtywllenl-rtqvwellPSK 83  Streptococcus ag...
ZP_00143782 218 TDITLIGHSIFDNWDivef---------------------------kgksVRNLGIGGISteqyqkfifdknkisgkSSI 270 Fusobacterium nu...
NP_266866    35 GQTLFVGSSLMEIFPiekweeag--------------------evtfshyIYNRAVRATTtsfllehi-esqifnlePSK 93  Lactococcus lact...
YP_060154    30 GGIVFAGDSLIEFFPlkkaf-------------------------gsclpIINRGIAGIDsqwllrhf-svqitdlePKH 83  Streptococcus py...
AAO36059    148 KNDVFMGDSISEALIyyef----------------------------ldeKNVCAKKAINinnaknev--gkisiknPRN 197 Clostridium teta...

Feature 1              #                                                                        
NP_345904    86 IFLLIGTNDIgkdv--pvnEALNNLEAIIQSVard---yplTEIKLLSIlpvnereeyq-----qavyirsnekIQNWNQ 155 Streptococcus pn...
YP_519850   118 VFIMLGSVDIlmpvedpqeLFREDLTKLINRIkee---lpgTEIYLQSItpvtqeal---------eqepryagIGEYNG 185 Desulfitobacteri...
ZP_01352045 249 AYVMFGLNELgwd---slkIFIEDYRDIIKGLrii---epnCEIIIQANypvtkklnd-------gdkvfnntnIKKYND 315 Clostridium phyt...
AAO35210    168 LFIFLGNNDLfeen-ltkdQFIKQYSSLVNTIrqn---vpnTKIYILSIlpvsnsaek-------ensflnrerILSFNN 236 Clostridium teta...
AAN58801     71 VFLMIGINDIgrgy--plsDIVARISNIIAQIran---hilTKIYVLSVlpvnesd------------qyagkvKIRNNA 133 Streptococcus mu...
CAD46830     84 VFILIGTNDIglgh--sqsEIIANITDIIAEIrae---symTEINILSVlpvseed------------dyiervKVRNNQ 146 Streptococcus ag...
ZP_00143782 271 YFVIAGTNDIvnkn-lsyfKISQQINLLIESIyevspnakiFFIETPSVafrid---------------rkkeeIFLLNE 334 Fusobacterium nu...
NP_266866    94 IFINIGTNDIgfei--peeEFLNNYDQILSQIesk---lpqTQVYVMRYypintvdfgqdsdektlfetrsnkkFQKASD 168 Lactococcus lact...
YP_060154    84 IFLLIGCNDIglgy--dkcHIVKTIVELISQIrsh---cvySQIYLLSLlpvsnnp------------ryqktvKIRTNA 146 Streptococcus py...
AAO36059    198 IYMLYGVNDMdntv--pskWFIDHYRTLIHKVkek---fpnSKIYVQSVlpvlpmvqk-------rkptmtnsyINECNT 265 Clostridium teta...

Feature 1                                             #  #                 
NP_345904   156 AYQELAsaym---qvefVPVFDCLTDQAGQLkk-eYTTDGLHLSIAGYQALSKSLKDYL 210 Streptococcus pneumoniae TIGR4
YP_519850   186 ILKEVAgq-------saVHYVDIGVLARENPa--lYAEDGIHFQKEFYQLWLQKLSESL 235 Desulfitobacterium hafniense Y51
ZP_01352045 316 LIKEMAdeeg----veyIDLYSFFANKDGNLpd-eATSDGIHLNPSYFKDWKHCLIDFG 369 Clostridium phytofermentans ISDg
AAO35210    237 AIKYMAe---------kHNLNYINTLPVIQGrenlYEQDGIHFKYDFYKYLLSYVENYI 286 Clostridium tetani E88
AAN58801    134 LIQVLNhhlqvlsgvnyIDLYPLLLDEKGELae-dYTTDGLHLTQTAYDKIAQTIKTDL 191 Streptococcus mutans UA159
CAD46830    147 AIKALNktlsvisginyIELYDLLVDEKGQLas-sFTKDGLHLTDQAYAKISETIKLHL 204 Streptococcus agalactiae NEM316
ZP_00143782 335 IIKKNLkke-----vtyIPINTFLIDDFGNLkl-eYTYDGLHFSEKGYQKLKEILEKEI 387 Fusobacterium nucleatum subsp. vincen...
NP_266866   169 KIKKLAdnhh----fhfIDVNDGLSDENGNLkk-eLTFDGAHLNPAGYQLVLENLKVYL 222 Lactococcus lactis subsp. lactis Il1403
YP_060154   147 MIDAINkdlamiptiefINLNTCLKDEKGGLsd-eNTLDGLHLNFPAYAKLAEIIQSYI 204 Streptococcus pyogenes MGAS10394
AAO36059    266 GLMKMAreen----vnfLNIKSMLNENNRDL----YEGDGIHFKPKFYTVWLSYIINKV 316 Clostridium tetani E88

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