Conserved Protein Domain Family
PHD_PHF23
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cd15631: PHD_PHF23 
PHD finger found in PHD finger protein 23 (PHF23)
PHF23, also termed PHD-containing protein JUNE-1, is a hypothetical protein with a plant homeodomain (PHD) finger. It is encoded by gene PHF23 that acts as a candidate fusion partner for the nucleoporin gene NUP98. The NUP98-PHF23 fusion results from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia (AML).
Links
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Statistics
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PSSM-Id: 277101
Aligned: 5 rows
Threshold Bit Score: 99.2217
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding sitehistone H3
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure evidence that human PHF13 (3O7A) binds two Zn2+ ions through its PHD finger
  • Comment:The PHD zinc finger is characterized as Cys4HisCys3
  • Citation:PMID 7583761
  • Citation:PMID 7701562
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # #           #  #    #  #             #  #
Q9BUL5       341 TCYCRKPFAGRPMIECSLCGTWIHLSCAKIKKTNVPDFFYCQKC 384 human
NP_001088965 214 TCYCEKPFAGRPMIECNICCTWVHLSCAKIRKSNVPDVYYCQKC 257 African clawed frog
XP_005279416 348 TCYCQKPFAGRPMIECNQCGTWIHLSCAKIKKTNVPDIFYCQKC 391 western painted turtle
Q7SXB5       260 TCYCGKPFAGRPMIECSQCNVWVHLSCAKIKKSNVPDIFNCHKC 303 zebrafish
XP_003384224 145 TCYCGRPYAGRPMIECSKCLTWIHLYCAKIKKSNVPDFFLCQKC 188 Amphimedon queenslandica

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