F-box domain found in F-box only protein 25 (FBXO25) and similar proteins
FBXO25, also called FBX25, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation. It controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. FBXO25 also plays a crucial role in tumorigenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Feature 1:putative Skp1 binding site [polypeptide binding site]
Evidence:
Comment:based on the structure evidences that other F-box superfamily members interact with Skp1
Comment:F-box proteins participate in SCF (Skp1-Cul1-F-box protein) complexes that function as ubiquitin E3 ligases, where the role of the F-box protein is to recruit target substrates.
Jiyao W et al.(2023). "The conserved domain database in 2023.",