Conserved Protein Domain Family
PIPKc_PIP5K1B
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cd17307: PIPKc_PIP5K1B 
Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins
PIP5K1beta (EC 2.7.1.68), also known as PtdIns(4)P-5-kinase 1 beta, or protein STM-7, or PIP5K1B, is encoded by the Friedreich's ataxia (FRDA) gene, STM7. FRDA is a progressive neurodegenerative disease characterized by ataxia, variously associating heart disease, diabetes mellitus, and/or glucose intolerance. PIP5K1beta is an enzyme functionally linked to actin cytoskeleton dynamics and it phosphorylates phosphatidylinositol 4-phosphate (PtdIns4P) to generate phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2).
Links
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Statistics
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PSSM-Id: 340444
Aligned: 6 rows
Threshold Bit Score: 698.28
Created: 8-Mar-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1: catalytic core residues [active site], 3 residue positions
Conserved feature residue pattern:K D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Lys proposed to bind the alpha-phosphate of ATP; mutation of this residue in PIPKI-alpha and PIPKII-alpha destroys enzyme activity.
  • Comment:1st Asp functions as a weak base
  • Comment:2nd Asp binds catalytic Mg2+ or Mn2+
  • Citation:PMID 9753329
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
O14986        27 SAIKGAIQLGIGYTVGNLTskpeRDVLMQDFYVVESVFLPSegSNLTPAHhyPDFRFKTYAPLAFRYFRELFgikPDDYL 106 human
Q5ZJ58        27 SAIKGAIQLGIGYTVGNLTskpdRDVLMQDFYVVESVFLPSegSNLTPAHhyPDFRFKTYAPLAFRYFRELFgikPDDYL 106 chicken
NP_001004579  27 SALKGAIQLGIGYTVGNLTskpdRDVLMQDFYVVESVFLPSegSNLTPAHhyPDFRFKTYAPLAFRYFRELFgikPDDYL 106 zebrafish
XP_007890837  53 SALQGSIQLGIGYAVGNLTskpeRDVLMQDFYVVESVFLPSegSNLTPAHryPDFRFKTYAPLAFRYFRELFhirPDDYL 132 elephant shark
XP_005999460  27 SAIKGAIQLGIGYTVGNLTsspdRDVLMQDFYVVESVFLPSegRNLTPAHhyPDFIFKTYAPLAFRYFRELFgikPDDYL 106 coelacanth
NP_001085811  27 SAIKGTIQLGIGYTVGNLTskpdRDVLMQDFYVVESVFLPSegSNLTPAHhyPDFRFKTYAPLAFRYFRELFgikPDDYL 106 African clawed ...

Feature 1                                       #                                                
O14986       107 YSICsEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIV 186 human
Q5ZJ58       107 YSICsEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGINIRIV 186 chicken
NP_001004579 107 YSICkEPLIELSNPGASGSLFYLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGINIRLV 186 zebrafish
XP_007890837 133 YSLCnEPLIELSNPGASGSLFYVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNLRTLLPKFYGLYCMQSGGSNIRIV 212 elephant shark
XP_005999460 107 YSLCnEPLIELSNPGASGSLFYVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIV 186 coelacanth
NP_001085811 107 YSLCsEPLIELSNPGASGSIFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGINIRIV 186 African clawed ...

Feature 1                                                                                       #
O14986       187 VMNNVLPrsMRMHFTYDLKGSTYKRRASRKEREKsnPTFKDLDFLQDmhEGLYFDtETYNALMKTLQRDCRVLESFKIMD 266 human
Q5ZJ58       187 VMNNVLPraLKMNFTYDLKGSTYKRRASRKEREKsnPTFKDLDFLQDmhEGLYFDsETHSALMKTLQRDCRVLESFKIMD 266 chicken
NP_001004579 187 VMNNVLPrsVKMHYKYDLKGSTYKRRASRKEREKpcPTYKDLDFVDMh-DGLYFDpETYNALMKTLQRDCRVLESFKIMD 265 zebrafish
XP_007890837 213 VMNNVLPrsVRMHYKYDLKGSTYKRRASRKEREKstPTYKDLDFMQDmsDGLFFDaETYNALVKTLQRDCRVLESFKIMD 292 elephant shark
XP_005999460 187 VMNNVLPssVKMHYKYDLKGSTYKRRASRKEREKscPTCKDLDFLQDmqDGLYFDtEMYTALKKTLERDCRVLESFKIMD 266 coelacanth
NP_001085811 187 VMNNVLPrsVKMNYKYDLKGSTYKRRASRKEREKssPTYKDLDFLQDtpEGLYFDpETYSALMKTLQRDCRVLESFKIMD 266 African clawed ...

Feature 1                                                                                        
O14986       267 YSLLLGIHFLdhslkekeeetpqnvpdakrtgmqkvlystamesiqgpgksgdgiitenpdtmGGIPAKSHRGEKLLLFM 346 human
Q5ZJ58       267 YSLLLGIHVLnsnvrekegessqnasdgkrpggqkvlystamesiqgpgksgdsvvtettntmGGIPAKSHKGEKLLLFM 346 chicken
NP_001004579 266 YSLLLGVHVLdqshrdgdgsavdgkrtvgqkvly------stamesiqgdgkaaealttddtmGGIPAKTHRDEKVLIFL 339 zebrafish
XP_007890837 293 YSLLLGIHNLdiaenenelesfqtasdgkrpggqkv--lystalesiqgatkskeslgtedviGGIPAKNNKGERLLLYM 370 elephant shark
XP_005999460 267 YSLLLGIHVIdhaskekdgessqnatdgkrpggqkv--lystamesiqcaakcgecvttentmGGIPAKNHKGERLLLFL 344 coelacanth
NP_001085811 267 YSLLLGVHVLgstskekegesshysidnkrpsvqkv--lystalesiqgpgkdvnsfikestmGGIPAKNHKGERMLLFM 344 African clawed ...

Feature 1           #                                                  
O14986       347 GIIDILQSYRLMKKLEHSWKALVYDGDtVSVHRPSFYADRFLKFMNSRVFKKIQ 400 human
Q5ZJ58       347 GIIDILQSYRLMKKLEHSWKALVYDGDtVSVHRPSFYADRFLKFMNTRVFKKVQ 400 chicken
NP_001004579 340 GIIDILQSYRFIKKLEHSWKALVYDGDtVSVHRPSFYANRFLKFMSSRVFRKNQ 393 zebrafish
XP_007890837 371 AIIDILQSYRFIKKLEHSWKALVYDGDsVSVHRPGFYADRFLKFMNCKVFKKSQ 424 elephant shark
XP_005999460 345 GIIDILQSYRLMKKLEHSWKALVYDGDsVSVHRPCFYADRFLKFMTTKVFKKTQ 398 coelacanth
NP_001085811 345 GIIDILQSYRLMKKLEHSWKALVYDGDsVSVHRPSFYADRFLKFMNSRVFKKVQ 398 African clawed frog

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