Conserved Protein Domain Family
Ebp2

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pfam05890: Ebp2 
Eukaryotic rRNA processing protein EBP2
This family consists of several Eukaryotic rRNA processing protein EBP2 sequences. Ebp2p is required for the maturation of 25S rRNA and 60S subunit assembly. Ebp2p may be one of the target proteins of Rrs1p for executing the signal to regulate ribosome biogenesis. This family also plays a role in chromosome segregation.
Statistics
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PSSM-Id: 461770
Aligned: 121 rows
Threshold Bit Score: 121.939
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESO05038      46 INNKVGLEEALRNLKR----DLPWQETLDICVE-PAPLpyclkddd-esdikgdGkEEENDFKLENLFYRQAQNAVLKGL 119
KJE91077      91 INNEERLRERLGDIAQqvdaSFPWAERLDLVSTvPIVL----------------D-DAQDDFKREMSFYNQALEAVKLAR 153
XP_001638992  46 FNNVEGLKRKYDQISQ----SLDWLERMDVTHK-PTADeendta----kdittpDpSVHDDFKREMMFYKQAQEAAKLGL 116
6_pfamImport   1 INNEVGLLEKLEEISQs---DLEWVERLDVTIKrnkse-----------vteddQtDVHNDFQREVSFYGQAQNSVISAM 66 
Q09958        86 INKSAEMKEKLAEITK----DLPWVETLEVVTP-HSEMd---------------KkVENDDFQRELNFYKQAEKAVQIAY 145 Caenorhabditis ...
Q6DRD0        50 INNVEGLNKCLAEFKK----NLPWIERLDLTNP-PAVNiiakaegraqqpegskEiNAEDDFQREMYFYRQAQATVLAAL 124 zebrafish
1_pfamImport   1 ANNVEGLKKCLADFKK----NLPWVERLDLTNK-PVDDvlakae----grpsndDvNPEDDFQREMYFYRQAQATVLEAL 71 
AAI59011      49 FNDVSGLRQSLKDLMN----ELPWAERMDVTVD-PVAEtagqngq---tapntpDiNAEDDFQREMCFYRQAQAAVLYAL 120
4_pfamImport   1 RNDTDGLKQCLAEFRQ----QLAWVERLDVTLG-PVADpvaqsa-----sasdaV-DPENDFQREMSFYRQAQAAVLEAL 69 
XP_003220244  50 INNVNGLKQCLSEFQR----DLDWVERLDLT-S-CLPEnaksaps--nhstdndAdDPENDFKREMSFYHQAQASVLEAL 121
ESO05038     120 ARLTAFNIPTKRPEDYFAEMLKSDLHMKKVKENILSLQAIKDKSEKAKKEREAKKVKKLADKEGRKEKKKEKleyKNTLK 199
KJE91077     154 PRLAAANIKFTRPDDYFAEMVKTDDHMRKVREALLSEHQAVERSEQAKKSRQMKQFGKKVQQQVLEDRQKQK---TSDLE 230
XP_001638992 117 LKLQKLRVSTKRPEDYFAEMVKTDDHMQRVRSKLLSRQQAMERSEKAKKQREIKKYGKKVQQEVLEKRQKEK---KDMLE 193
6_pfamImport  67 LRLHSSGINTKRPDDYFAEMAKKDDHMKKVGVKLLALKKRRETSEKNQNNFKLRKYGKQVQRAVTLERQQKK---REVLS 143
Q09958       146 PRLLNLGIKVLRPTDYYAEMAKSDTHMQKVRKRLLGIQEMKERQEAFRRIREEKKFAVKVQKEVLAAKNTEK---KNLAE 222 Caenorhabditis ...
Q6DRD0       125 PKLQKFKIPTKRPDDYFAEMAKTDQHMQKIRKKLLLKQEVMEKSEKAKRLREQRKYGKKVQTEVIQNRQKQK---KAMLS 201 zebrafish
1_pfamImport  72 PKLKKLNIFTKRPDDYFAEMSKTDQHMQKIRKKLMQKQVAMENSEKAKKLREQRKFGKKVQVEVLQKRQKQK---RDMMT 148
AAI59011     121 PRLHQLKVATKRPDDYFAEMAKTDQHMQKIRQKLQIKQAAMEKSEKAKQLRALRKYGKKVQTEVLQKRQKEK---SAMMT 197
4_pfamImport  70 PRLRKLQVPTRRPDDYFAEMAKSDQQMQKIRQKLKSKQEAMERSEKAKQLRAMRKYGKKVQVEVLQRRQKEK---KNMLN 146
XP_003220244 122 PRLHQLKIPTRRPDDYFAEMAKSDQQMQKIRQKLKSKQEAMEKSERAKQLRALRKYGKKVQTEVLQKRQKEK---STMLN 198
ESO05038     200 KVR--KKlnlgQRGKI--LNpddlFEDTSDRkSVEVvyRKEQkikqqhkqqqqMNNNKNNNDSsyivpeKPMKANK---- 271
KJE91077     231 AIKkfKK----DRSAKpdFL----DDGDDQF-NIGVdkEES----------------------------HSQKTNS---- 269
XP_001638992 194 AVKkyRKg---KQTAPdfMKeddf--------------------------dvnAESKSKGKPQ------QRNQINH---- 234
6_pfamImport 144 SIKkfKKg---KITNTdfLDds------------------------------sKENRPQGKKLsqlqklQKHKVNH---- 186
Q09958       223 AVKkhKKg---MKQQL----------------------EDMLnnvkrhgldqdDDAPTGAFGDrl---gGRGGAGRggag 274 Caenorhabditis ...
Q6DRD0       202 AVKkyQKg---MTDKLdfLEgd----------------------------------qNQGQKG-------SSTKKQinkk 237 zebrafish
1_pfamImport 149 AVKkyQRg---MTDKLdfLEg--dK-------------EGKN-----------GPASSKKQMG------KRGGPSS---- 189
AAI59011     198 QIKkyQKg---LSDKLdfLEg---D---------QT--QKKN------------KTGGSAAQK------AKKGPSA---- 238
4_pfamImport 147 AVKkyQKg---LSDKLdfLD----EEQT-----------SSQ-----------GNKKGNASQR------TKKGPNA---- 187
XP_003220244 199 SIKkyQKg---LSDKLdfLDge---------------------------------kASAPQRK------KQATGGKpank 236
ESO05038     272 ------K-----RMMKNKKFGFGGQKKRSKYNTRESVDEVQ-FKSFRSP------------AAikkyknknksnnRRNKK 327
KJE91077     270 ------K-----RSYKNDKYGNGGKKRGSKRNTRDSASDDSsFNFARNKalpkgfksagvaKKfgggaggkskapRPGKS 338
XP_001638992 235 ------K-----RKAKDKKFGFGGKKRNIKRNTQKSTSDVSsFNSRKHSk-----------APkpnkpgvkrknqRPGKS 292
6_pfamImport 187 ------K-----RNFRDKKYGFGGKKKGQKRNTNTSSNDVSgFKRKVhgnk---------------------knvRPGKS 234
Q09958       275 rggsmrNagelkRKLKSDKFGYGGKKKGMKRNNKESFNDLFg-----A--------------PrggfggrgrgggRGGRG 335 Caenorhabditis ...
Q6DRD0       238 --npnaK-----RKYKDKKFGFGGRKKGSKWNTKESHDDVSaFKAKMAHg----------kGGgkvgnr-vkmnkRPGKE 299 zebrafish
1_pfamImport 190 ------K-----RKYKDQKFGFGGRKKGSKRNTKESHNDVSgFRAKAAH------------GKggkkfgkggknkRPGKE 246
AAI59011     239 ------K-----RRYKDQKFGFGGKKKGSKRNTKESYNDVSgFRASVAHgk---------gQRrpgkkggknankRPGKK 298
4_pfamImport 188 ------K-----RRYKNQKFGFGGKKKGSKWNTKESFNDVSsFQSKVAHnkg------pgkGGrggkggkkalnkRPGKR 250
XP_003220244 237 --gqsaK-----RRYKNQKFGFGGKKKGSKWNTKESHNDVSsFRGSKAHy----------kGPgkagk--knvnkRPGKK 297
ESO05038     328 K 328
KJE91077     339 R 339
XP_001638992 293 R 293
6_pfamImport 235 K 235
Q09958       336 G 336 Caenorhabditis elegans
Q6DRD0       300 A 300 zebrafish
1_pfamImport 247 T 247
AAI59011     299 V 299
4_pfamImport 251 A 251
XP_003220244 298 V 298
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