Conserved Protein Domain Family
ApoO

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pfam09769: ApoO 
Apolipoprotein O
Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.
Statistics
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PSSM-Id: 462891
Aligned: 102 rows
Threshold Bit Score: 82.2179
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003718574  76 QQQQVvaRG------PTPTDQLAAQIRRARLFLHRQAAVAEDGV-----------NAAMDRAFDLEQSFTSTLASLAPSR 138
XP_007493475  41 SLYSI--PNfeskyvEEPRSPLEEGISQLRKYAGPYTYWFQDAY-----------NKTKPTVDAAIQQGIASCEILQNPP 107
XP_006085688  41 SLYSV--PEiqskyvEEPRTQLEESISHLRQYCKPYTSWCQEMY-----------SQTEPKMQSLVQWGLDSYEFLQNAP 107
XP_005334861  41 SLYSA--PKgqckyvEEPRTQLEESISQLRHHFEPYTSWCQETY-----------SKTKPKMQSLVQWGLDSYEYLQNAP 107
XP_023410919  52 SLYSV--PEgqskyvEEPRTQLEENISQLRHYCEPYTSWCQEKY-----------FYTKPKVQSIVQWGIDNYEYLQNAP 118
Q3B747        40 SLYSV--PQqniqpvESERGQLEERVAELRLMTEPYLTWCQGAY-----------GTVKPKVDSTVQFGQNSYAYLKNPP 106 zebrafish
XP_023191437  65 SLYTAppPPqtlrheESEAGQLEEKVATVRKLAEPYATWCQSTY-----------TKIKPKVQKVVQLGNDTYVYLQNPP 133
Q7T173        45 SLYDT--PEprlryeEPDVGPVEQGVASLRKTVEPYCSWCQERTqfavdkiqsyyKTVEPGVDTTQNIVQDIFTFLKDPP 122 zebrafish
1_pfamImport   1 SLYTR--PEpelecvEPEAGSLEQSVTSLRKWAEPYTNQCQQTCqmvmekveevyRSVEPAVATSVSTVSEAYQFLSDPP 78 
XP_004078617  42 SLYTApqKPhy---vEPAAGQLEEHVATLRKLVEPYTGWCQATV-----------GKLKPKVESLVQSGNDSYVYLQNHP 107 Japanese medaka
XP_003718574 139 esgERLMPGLVYVLVASMAGSIVSRrRNVVFRAAAPIAFGVAAGWAVLPVT----MRNVGDLAWRYEQ-RFPVVA 208
XP_007493475 108 ---PGFLPRLGVIGFSGILGYFFAR-GSKLKKLVYPIGFMSITASVYYPQEafefAQVNGEKLYDWGLrVFIILE 178
XP_006085688 108 ---PGFFPRLGVIGFAGIIGLLLAR-GSKIKKLVYPPSFMGLAASLYYPQQaivfFQVSGEKLYDWSLrGYIVVE 178
XP_005334861 108 ---PGFFPRLGVIGFAGLVGLLFTR-GSKIKKLVYPPAFMGLAASIYYPQQaiafAQVTGEKLYDWGLrGYIVIE 178
XP_023410919 119 ---PGFFPRLGVIGFAGLVGLLFAR-GSKIKKLIYPPGFMGFAASVYYPQQaisfAQVSGELLYDWGLrGYIVIE 189
Q3B747       107 ---PEFYPRAGIIGFAGILGLFLGR-GSRLKRLIYPTGLMAVGASMYYPQEavtiAKSTGDSVYDWALqAYVTVE 177 zebrafish
XP_023191437 134 ---KDFYPRAGVIGLAGVAGLFLAR-GSRIKKVLYPTGFMTLGASLYYPEQaaaiAKSTGDSAYDTAVqSYAAVE 204
Q7T173       123 ---SEFYPSVGVIGFSGILGLFFAK-GSTVKRLIFPTGLMALCASVFYPQHaasaARTTKDYMYSWGSeGRAVLE 193 zebrafish
1_pfamImport  79 ---PNLYPSVAAVGFSGLLGLYLAK-GSRVKRVVFPAGLMALSASVFYPQLtaslLKASRDRALTWAQqGRGALE 149
XP_004078617 108 ---KDFYAQAGIIGFTGLLGLFLAR-GSRVKKLIYPAGLMTVSASLYYPEEavtiAKSTGDSVYGYAVrGFAAAE 178 Japanese medaka
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