Conserved Protein Domain Family
Glypican

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pfam01153: Glypican 
Glypican
Statistics
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PSSM-Id: 460084
Aligned: 15 rows
Threshold Bit Score: 627.479
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005802141  14 ALSGTRSPAAAA-GRSCADTRQVYSEKGY-STSTAPVTQISGEHLRLC-PQDYTCCSSQMEETLSLQSERDFLKATEDNS 90 
XP_006637812  13 ATPIVGENTSGK-ARSCSDVRQFYSGKGF-HLVGVPQTEISGEHLRIC-PQGYTCCTSEMEESLSTLSRREFEGLVKEAG 89 
F1QCC6        14 SVSLSAENAGGK-ARSCTDVRQFYSGKGF-TLNGVPQSEISGEHLRIC-PQGYTCCTSAMEETLSNLSRREFEGLVREAG 90  zebrafish
XP_014347969  17 SSVCTGSPTS-K-PKSCSEVRQLYNSKGY-SLNGVPHTEISGEHLRVC-PQGYTCCTSEMEENFASLSRRELEGKVKEAG 92 
Q5RE54        21 A------GADVK-ARSCGEVRQAYGAKGF-SLADIPYQEIAGEHLRIC-PQEYTCCTTEMEDKLSQQSKLEFENLVEETS 91  Sumatran orangutan
XP_001514704  15 ALSLSPLAAEPK-SKSCSEVKRLYVSQGF-NKNDAPSHEINGDHLKVC-PQGYTCCSQEMEEKYSQQSKDDFRGSVGEHC 91 
AAK69693      17 A----SAQADQK-SKNCNEVRTAYSSKGF-NVNDVPNKGVQGAHLKVC-PQGFSCCTLEMEEKLSQLSRVDLKVPVHQLS 89 
Q24114        53 QRDSRAKDAVGGsTHQCDAVKSYF------ESIDIKSSGTYSEKGAIC---GGNCCNNATELELRDKAAGMFEQLLHHHT 123 fruit fly
XP_509696     17 ALVGSARSEGV---QTCEEVRKLFQWRLLgAVRGLPDSPRAGPDLQVCiSKKPTCCTRKMEERYQIAARQDMQQFLQTSS 93 
P51653        16 PGPGPGHGSEAKvVRSCAETRQVLGARGY-SLNLIPPSLISGEHLQIC-PQEYTCCSSETEQKLIRDAEVTFRGLVEDSG 93  Norway rat
XP_005802141  91 QFLLTTFTQRHRRFDEFFRELIDLSEKSMNQMFTKTYGRLFTQNTHVFQELFVELRRY------YSGGS--V-------- 154
XP_006637812  90 HSLQLSLTTQYKSFDGYFLDLLNQSERSLQDSFPAVYGELYTQNARLFKDLYAELRRY------YRGSN--I-------- 153
F1QCC6        91 RSIQALLNAQYRTFDTYFLELLNGSERWLEEAFVAALGELYRLNAGVFRDLYAELHRY------YSGAS--L-------- 154 zebrafish
XP_014347969  93 RSIQASLNTQYKNFDGYFQEVLNRSESSLHEAFLGLYGDLYTQNTQLFKELYGELRRY------YHGSN--I-------- 156
Q5RE54        92 HFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRY------YTGGN--V-------- 155 Sumatran orangutan
XP_001514704  92 NLLQTTFGSRYKKFDEFFKELLENAEKSLNDMFVRTYGRLYMQNSELFKDLFVELKRY------YVGGN--V-------- 155
AAK69693      90 SNLQSTFTQRHRHFDQFFRELLDNAEKSLNHMFVRTYGLMYVKNKELFEGFFSDLRRY------YSHGSseV-------- 155
Q24114       124 SSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHliytsnYTNSNgqLgrrgigsv 203 fruit fly
XP_509696     94 STLKFLISRNAAAFQETLETLIKQAENYTSILFCNTYRNMALEAAASVQEFFTDVGLY------LFGAD--V-------- 157
P51653        94 SFLIHTLAARHRKFNEFFREMLSISQHSLAQLFSHSYGRLYSQHAVIFNSLFSGLRDY------YEKSG--E-------- 157 Norway rat
XP_005802141 155 --SLTEVFSDFWSGLVERVF-SLVNPQYQ--FSD---DYLECVSKHTE----QLQPFGDVPRKLRVQVSRAFIAARALSQ 222
XP_006637812 154 --NLEEVLNEFWVRLLERLF-KAQNPQYV--FGD---EYLECAVKQTE----TLRPFGDVPRELKLKATRAFIAARSFVQ 221
F1QCC6       155 --NLEEALDEFWMKLLERLL-KASDPETAslLSD---DFLDCASKQTE----TLRPFGDAPRELKAKLVRAFIAARAFVQ 224 zebrafish
XP_014347969 157 --NLEEALTEFWTRLLERIF-KQLNPQYQ--LTD---EYLDCALKQAE----QQRPFGETPRELKARATLAFIAVRSFIQ 224
Q5RE54       156 --NLEEMLNDFWARLLERMF-QLINPQYH--FSE---DYLECVSKYTD----QLKPFGDVPRKLKIQVTRAFIAARTFVQ 223 Sumatran orangutan
XP_001514704 156 --NLEEMLNDFWARLLERMF-RLVNPQYH--FTD---EYLECVSKYTE----QLKPFGDVPRKLKLQVTRAFVAARTFAQ 223
AAK69693     156 --NLDDMLAEFWSELLERMF-RLVNVQYE--FSD---SYMECVSRHTD----QLKPFGDVPRKLRLQLTRSFIAVRAFTR 223
Q24114       204 qsNLEEAVRHFFVQLFPVAYhQMVHLSKNn-LGDlheDYVNCLQHNFD----EMHPFGDIPQQVQSNLGKSVHMSNVFMN 278 fruit fly
XP_509696    158 --NPEEFVNRFFDSLFPLVYnRLINPA----VTDsslEYSECIRMARR----DVSPFGNIPKRVMGQMGRSLLPSRTFLQ 227
P51653       158 --GLDDTLADFWAQLLERAF-PLLHPQYS--FPP---DFLLCLTRLTStadgSLQPFGDSPRRLRLQITRALVAARALVQ 229 Norway rat
XP_005802141 223 GLAFGRDMVNTATKL---TADSECVRGLMRQWYCSLCRGLPF-----LRPCHSLCLNVMKGCLANQAE-LDTEWNNFIDA 293
XP_006637812 222 GLGVSSEVVRKVSQV---PLSPECTRALMKLMYCPHCRGMPS-----VKPCINYCRNVMKGCLANQAD-LDTEWRNLIES 292
F1QCC6       225 GLNAAGEIVRKVSQV---PLSPECNRAIMKLVYCPHCRGLGS-----VKPCINYCKNVMKGCLANQAD-LDTEWQSLIET 295 zebrafish
XP_014347969 225 GLSMASDVVRRVSQV---PLSPECTRAIMKLLYCPHCRGMSS-----VKGCQNYCHNVMKGCLANQAD-LDTEWRAFVDA 295
Q5RE54       224 GLTVGREVANRVSKV---SPTPGCIRALMKMLYCPYCRGLPT-----VRPCNNYCLNVMKGCLANQAD-LDTEWNLFIDA 294 Sumatran orangutan
XP_001514704 224 GLAVARDVVNKVSVV---NPTPSCTHALLKMMYCPHCRGLVT-----VKPCYNYCSNVLRGCLANQGD-LDSEWNHFIDA 294
AAK69693     224 GLTLMPDVVRKVSTV---SASPSCVRASMKMLYCPYCSGQVA-----LKPCKNYCLNVMRGCLANQAD-LDTEWNNFLDS 294
Q24114       279 ALLQAAEVLSEADALygeQLTDTCKLHLLKMHYCPNCNGHHSssrseTKLCYGYCKNVMRGCSAEYAGlLDSPWSGVVDS 358 fruit fly
XP_509696    228 ALNLGIEVINTTDYL---HFSKECSRALLKMQYCPHCQGLTL-----TKPCMGYCLNVMRGCLAHMAE-LNPHWHAYIRS 298
P51653       230 GLETGRNVVSEALKV---PMLEGCRQALMRLIGCPLCRGVPS-----LMPCRGFCLNVAHGCLSSRG--LEPEWGGYLDG 299 Norway rat
XP_005802141 294 L-YVVSEKLEGPFNFELAADSISVKVSEAIMHMQENSVSISRKVFQGCGNPSPa---RNKRSPSESGGNRKPFRTYtpee 369
XP_006637812 293 M-LQVADRFNGPSSVEVVIGSIHTRISEAMVNMLDNSAHFTSKVFQACGTPRV----GGTQVSGSEDKKKRGKSPV---- 363
F1QCC6       296 M-LQVASSFGAEPSMDTVIYSIPVRISEAVLAMQENMEIYTSKVFKACGDRGE----EGTPSSISEEPKKKERTVTaley 370 zebrafish
XP_014347969 296 M-LQVSDRFEGTSSVETVFGSIHVRISEAIFNLQENEEHIRAKVFQACGNPKA-----NSRGSEGNEKKRM-KPVSd--- 365
Q5RE54       295 M-LLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPapalRSARSA-PENFNTR-FRPYnpee 371 Sumatran orangutan
XP_001514704 295 M-LMVAERLEGPFNIESVMDPIDVKISDAIMNMQENSMQVSQKVFQGCGPPKPlspgRSSRSVSESGFSAR-FRPYnpee 372
AAK69693     295 M-LGLAERLEGPFNFESVVDPIDVKISDAIMNMQENSMQVSQKVFQGCGQPKLsmgfRSRRSAKDSGFPGR-FRPYspea 372
Q24114       359 LnNLVTTHILSDTGIINVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLtpysSGEPDARPpph------------ 426 fruit fly
XP_509696    299 L-EELSDAMHGTYDIEHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRPVRtp-tQSPRCSFDQSKEKHGMKTTtrns 376
P51653       300 L-LLLAEKLQGPFSFELAAESIGVKISEGLMHLQENSVKVSAKVFQECGTPHPvq-sRNRRAPAPREETSRSWRSSaeee 377 Norway rat
XP_005802141 370 kpTTAAGTNLDRLVTELKERLRPMRGFWVSLPHTICNdERMAADVTNEDR-CWNGQT-RGRYLPDVTGNGLASQINNPEV 447
XP_006637812 364 --DEKAGLGLEKLVSDVTGKLREMQQYWVQLPNALCT-DKVSAAPASEDK-CWNGMS-RASYLPEVMGDGLASQINNPEV 438
F1QCC6       371 kpSPKSAARLEVQVTDVYSKLKEMQLYWIQLPSALCS-GK-TASSTTGDK-CWNGIT-KASYLPEVMGDGLANQINNPEV 446 zebrafish
XP_014347969 366 --DTSAGHRLEKLVLDVKGKLGEMKHYWVALPSALCG-NKITAGPTNEDR-CWNGMT-KSRYLPEVMGDGLANQINNPEV 440
Q5RE54       372 rpTTAAGTSLDRLVTDIKEKLKLSKKVWSSLPYTICKdESMTAGTSNEEE-CWNGHS-KARYLPEIMNDGLTNQINNPEV 449 Sumatran orangutan
XP_001514704 373 rpTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNdEKMAAGNVNEDE-CWNGNA-QSRYLFAVTGNGLANQGNNPEV 450
AAK69693     373 rpTTAAGTTLDRLLTDVKKKLKHAKKFWSTLPDTVCVgERIAPS----DD-CWNGTA-KSRYESVVMSSGLANQVSNPDV 446
Q24114       427 knNVKWATDPDPGMVLFLSTIDKSKEFYTTIVDNFCDeQQHSRD----DHsCWSGDR-FGDYTQLLINPGTDSQRYNPEV 501 fruit fly
XP_509696    377 eeTLANRRK------EFINSLRLYRSFYGGLADQLCAnELAAAD----GLpCWNGEDiVKSYTQRVVGNGLKAQSGNPEV 446
P51653       378 rpTTAAGTNLHRLVWELRERLSRVRGFWAGLPVTVCGdSRMAADLSQEAApCWTGVG-RGRYMSPVVVGSLNEQLHNPEL 456 Norway rat
XP_005802141 448 EVDIARPDVKVKQLIVDLKVVTNKLKHAER-------------GQDINFI----DSEEGS--GSGGGdhderysddwpgy 508
XP_006637812 439 EIDITKPDMTIRQQIMQLKIMTNRLRNAFN-------------GNDVDFQ----DTSDDVs-GSGSG------------- 487
F1QCC6       447 EIDITKPDRTIRQQIMLLKIMSNRLKNALE-------------GNDVDFQ----DTSDDFs-GSGSG------------- 495 zebrafish
XP_014347969 441 DVDITKPDMMIRQQIMQLKIMTNRLRNAYK-------------GNDIDFL----DSSDDIs-GSGSAd------------ 490
Q5RE54       450 DVDITRPDTFIRQQIMALRVMTNKLKNAYN-------------GNDVNFQ----DTSDESs-GSGSGs------------ 499 Sumatran orangutan
XP_001514704 451 EVDITKPDMVIRQQIMALRVMTIKMKNAYN-------------GNDVDFI----DISDESs-GEESGs------------ 500
AAK69693     447 EVDITKPDMVIRRQIAVLKEMTSWLKAAYT-------------GNDISFT----SDDAGS--GEESGs------------ 495
Q24114       502 PFNAKAQTGKLNELVDKLFKIRKSIGAAAP-------------SNSIQATh---DIQNDMgeGSGGGegqigddeeeygg 565 fruit fly
XP_509696    447 KVKGTDP--VISQIIDKLKHVVQLLQGRSPkpdkwellqlgsgGGMVEQVsgdcDDEDGCg-GSGSGe------------ 511
P51653       457 --DTSSPDVPTRRRRLHLRAATARMKAAAL-------------GQDLDMH----DADEDAs-GSGGGq------------ 504 Norway rat
XP_005802141 509 GPHSPPYSKTPRNPV----SNPAKPTRGreRNGSKWSRNHGQGRIKASAtsphlhiSSLVPLLS 568
XP_006637812 488 ACVEELCPRSTDRNTipntDQPIQYAIP--AENKKVVKGTASQALPHST-------LLLLSLAV 542
F1QCC6       496 MCADHLCVRGRPPVFgpktDRPKLYATG---PENKRVKGSGNQIQPSF--------ILLIVFFV 548 zebrafish
XP_014347969 491 GCPEETCKGSRKKVIlsvaGQPKVLTRP---LGTGSQGGGGGMALPSALtltlswaVTLahylw 551
Q5RE54       500 GCIDDVCPTEFEFVTt---EAPA-------VDPDRREVDSSAAQRGHSLl-----sWSLTCIVL 548 Sumatran orangutan
XP_001514704 501 GCESPQCASEFVFNVtdnaGKPQ-------NSDRNTKDSSSASTVGPSRvavifgiMFLVmqrq 557
AAK69693     496 GCDSPSCEGDGDIYF----STPA-PGKPriLKTQEVEQASSGTRLAPCSl-----aLALASLLL 549
Q24114       566 AHGSGDGSGDGP-------HTPIEESEGttTNEVESRDSGKTSGSNPLEgtatwmlLTLVTMLF 622 fruit fly
XP_509696    512 ------VKRTLKITDwmpdDMNFSDVKQihQTDTGSTLDTTGAGCAAATesmtftlISVVMLLP 569
P51653       505 QYADDWKAGAAPVVPp---ARPPRPPRPprRDGLGVRGGSGSARYNQGRsrnlgssVGLHAPRV 565 Norway rat
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