Conserved Protein Domain Family
Pro-NT_NN
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pfam07421: Pro-NT_NN 
Neurotensin/neuromedin N precursor
This family contains the precursor of bacterial neurotensin/neuromedin N (approximately 170 residues long). This the common precursor of two biologically active related peptides, neurotensin and neuromedin N. It undergoes tissue-specific processing leading to the formation in some tissues and cancer cell lines of large peptides ending with the neurotensin or neuromedin N sequence.
Links
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Statistics
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PSSM-Id: 462161
Aligned: 7 rows
Threshold Bit Score: 199.651
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9D3P9         6 LQLVCLTLLAFSSWSLCSDSEEDVRALEADLLTNMHTSKI---SKASPPSWKMTLLNVCSLINNVNSPAEEAGDMHDDDL 82  house mouse
XP_003771020   7 IPLVCMMFLAFTSQSLCSDSEEEMKALEADLLTNMYTSKI---NKARFPHWKMTLLNVCSLVNNLNSPAEETGETGEDEL 83 
P10673         7 IQLVCMILLAFSSWSLCSDSEEEMKALEADLLTNMHTSKI---SKASVSSWKMTLLNVCSFVNNLNSQAEETGEFREEEL 83  dog
XP_003221181   8 MQLACAMLLAFASWSLGSDSEEEMKALEADLLTNMYTSKV---NKAKLPPWQMTLLNICDLISNLNNQ-EETAGNTEDDL 83 
ALD51567       3 AQLACMLLLCFTCGGLCTDVDRDPQALEEELVRSLFPSKVakqNKQSAPYWRVSLVDLCRMLNGVSA---AELGGEGELE 79 
XP_017207567  13 mqltsflllfllcnglcSDIDQGKRAIEDEVLRSLLTSKVk-aSRHIAPLWQLPLQDVCRMVNGLGDSWLEAWANEEAAE 91  zebrafish
XP_006633673   4 qLICLVLLFA-ASDGMCSDSDQEMKMIEEELLNSLYTTKV---NKQRLPSWKLSLLNMCRLINDPSRQGDDVWTSDEEGF 79  spotted gar

Q9D3P9        83 VGKRKLp--LVLDGFSLEAMLT--IFQLQKICrsRAFQHWEI------IQEDILDNVNDKNEKEEVIKRKIPYILKRQL- 151 house mouse
XP_003771020  84 VMRRQL---STLEGFNLEAMLT--IYQLQKICrsRAFQHWEL------LQEDVLESGNLNREKEEIMKRKTPYILKRQL- 151
P10673        84 ITRRKFp--TALDGFSLEAMLT--IYQLQKIChsRAFQQWEL------IQEDVLDAGNDKNEKEEVIKRKIPYILKRQL- 152 dog
XP_003221181  84 MTRR-----PTLDSFTLEAMLT--LYQLQKVChsRTFQQWEL------FQQDVYDPENSSQDKD-LMKRKTPYILKRQL- 148
ALD51567      80 F--------NFVNSKTLHYLSAniIINLIYLN--KAPENRKEkyshcvILRGPQDYLE--GNRDNPLKRKSPYILKRQAa 147
XP_017207567  92 DTEVHAdyeQRVSGTLLQMLEE--MHDIQNLC--RVLQPRE--------LQDEQEYLELEQNSDSPLKRKSPYILKRQL- 158 zebrafish
XP_006633673  80 ISREQIs--TFPDSFSLEKLAD--FYQLQNLC--RILHGGE-------FNQKTEDYLDQDYKNEGPLKRKSPYILKRQL- 145 spotted gar

Q9D3P9       152 YENKPRRPYILKRGSyYY 169 house mouse
XP_003771020 152 HVNKARRPYILKRSSsYY 169
P10673       153 YENKPRRPYILKRGSyYY 170 dog
XP_003221181 149 HVNKARRPYILKRSS-YY 165
ALD51567     148 HTTKSRRPYILKRST-TY 164
XP_017207567 159 RTNKSRRPYILKRSV-IY 175 zebrafish
XP_006633673 146 HINKPRRPYILKRST-LY 162 spotted gar
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