Conserved Protein Domain Family
DUF4507

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pfam14964: DUF4507 
Domain of unknown function (DUF4507)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 346 and 434 amino acids in length.
Statistics
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PSSM-Id: 464409
Aligned: 22 rows
Threshold Bit Score: 259.934
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDO36968      23 KYINGCFSCLKFPACCQQVLIVL--DKYYASYQPCTLQNPalfvmSFLEELIEKYLYHTTDKTGQ--------------- 85 
XP_002040665  11 llrkGEMKMDNYPTCAVEALTRL--ETLIASRNKQ----------NMVMQIISEFIFLERTSKDGdvrksq--------- 69 
EFX85120       9 PDLHRILRRLDFPQSAKEALACLgmEKQLCLPLAHTRPPTsk-qlDYIGEIIDEFVFCEIDHKGArr------------- 74 
XP_002408288   2 TDVRVSLRKIEFPTVIFEALRQM--QKLLSNEGRSPTYA------HVAKEIAEEFIFQDFDQRRQpphhhhhhhpsqqpp 73 
XP_002613624   2 pSLRDSLAYEGFPQATRRVLEHV--EASCSGGEAG----------TNLGALVEEFVHFRPPDALPhh------------- 56 
XP_011405071  23 SEIDQTLKTLQKPAACNFILSMV--ERYIRSLSSPDLVVSslpnkEKLLSLIDSYILLVPTAAASssv------------ 88 
Q7ZTY6         2 SDIRHALLRRDPLSAAKEVLYHL--DISLGSALQSSAGPPag-leKSTVELVEEFIFHVSKDRNIqs------------- 65  zebrafish
XP_015215558   2 SDIRHSLLRRDALSAAKEVLYHL--DIYFSSQLQSTAVPIv---dKGTLELVEEFIFHVPKERGVlp------------- 63 
XP_014353234   3 SDIRHSLLRRDALSAAKEVLYHL--DIYFSSQLQKVPLPIv---dKGTIELVEEFVFQVPKERAAqp------------- 64 
XP_003975881   2 gDIRQSLLPRDVLSAAKELLYHL--DIYICNLLQSGRQPPqv--dTKTLELVEEFILHAPKDRNTsa------------- 64  torafugu
EDO36968      86 -----GLSAILELRLLEVMCSHFQTQE-SDFVRYCVFDLLFGVSRDDlree--------------------kfeCRIDLL 139
XP_002040665  70 alpisQMNLFQEFQLIIALIEYFSRPG-RDATRNAIFLSLFGSHLTP---------------------------QRSKLL 121
EFX85120      75 ----kRLNPLQELQLLEVLLGYFAAGE-DKVILNTVFMMLFTPPHTPspspspspsgfaradvftpgtataalsDRMRIL 149
XP_002408288  74 qlrrrKMSAIRELQIIEIMASSFQSSR--PDMCQKVFFILFPSADPAvm------------------------dTRVPIL 127
XP_002613624  57 ----tGLNALQELQLLQILSDYFGAKT-NVGLARQVFMVLFGTRGGAdrl----------------------tdHKVKLL 109
XP_011405071  89 ---ewPFNVFEELELLEALRGQVEERQlSKEIQLALFDTLFGLADDDeva----------------------saHRLSLL 143
Q7ZTY6        66 ----kRMSCVQELQLLEIICSYFQEQS-KDAIRQVIFSALFSLQGNKad------------------------eSRMAML 116 zebrafish
XP_015215558  64 ----kRMSSLQELQLLEIMCSYFQEQS-KDAVRQVIFSALFSPQGNKad------------------------dSRMAML 114
XP_014353234  65 ----kRLNSLQELQLLEIMCNYFQEQS-KDSVRQIIFSALFSPQGNKad------------------------dNRMIIL 115
XP_003975881  65 ----rRMSALQELQLLEIMCSCFQEQS-RDAVRQLMFNALFGLQGNQad------------------------eSRMALL 115 torafugu
EDO36968     140 TKLVSMAVA-LQSGNVLDCMAWWIQKHRHAPDFVVKIASSIVDDYTCL-VP-----ASLPFLESVSFISPPLACQLIITQ 212
XP_002040665 122 SRLISTAVS-GSVAPLLSSAGTWMQQVGCKTPLSLEVAQNIVSDFISY-SR-----KTPEQLKQLPMVGPHFAANFMVAV 194
EFX85120     150 ARLVSAAVA-SRNLAVLNCTGVWMQQLGCLSQHSLNLSRVFIEDYFVLnTPqsnisSSTSYLEQLPQQAPHFTSCFLTAA 228
XP_002408288 128 SRLVSLSIA-LKSHNALNCVGFWMHVCGCTSEPSLHIVRHVIGDYLSL-IP-----SSAEMLKDLADISPLFCASLATSL 200
XP_002613624 110 GKLVSMCIA-TQHEMVLDCTAYWILQEGASSSPVLTLLTSIIQDYCML-MP-----GTLDTLQRVDKTSPSFACQFVTIV 182
XP_011405071 144 KKLVSLSISgLGNGTVLHCTTYWMEL---YPIAAAELATNIYSEFCEL-LP-----NAMEPLLALGNNCPSFTKLLILHL 214
Q7ZTY6       117 GKLVSMSIA-VCRVPILECAAIWLQR--THSAWCVRLAQVLMEDYCTL-VP-----CAISTLQNICSASPRFCCQLITAV 187 zebrafish
XP_015215558 115 GKLVSMAVA-VCRVPILECAALWLQR--THAIYCVRLAKVLVDDYCSL-VP-----GSVQTLQQIFSASPRFCCQFITAV 185
XP_014353234 116 GKLVSMAIA-VCRVPVLECCALWLQR--TPAVYCVRLSRILVDDYCSL-VP-----GSGQTLKQIFHASPRFCCQFITAV 186
XP_003975881 116 GKLVSMAIA-VGRVPILECAATWLQR--SHRVFCVRLAQVLVDDYCSM-VP-----GSVSTLQNIHSASPRFCCQFITAV 186 torafugu
EDO36968     213 TSVYTMKPQPDRDeteaqPSNTLVKVIVKWISTNLGICLAKPNNTflsLPSlhnppmsePAATPL--PTCPVLGLLTWTV 290
XP_002040665 195 ADLYLNEQRSQTLn---pPPDALLDTITEWMAENPTLCQASQQPL----VL--------PAGAIAmpFTTPLAGLLRWVV 259
EFX85120     229 AELYGGIDGNRSAyi--pPPMCLLNTIVNWVSSNPRLCLTPLTLNl-qPLL--------PKGSIVmtSVTPLAGLLKWCV 297
XP_002408288 201 THMTPTN-----------PSVEIVDLLASWVRAQPLLCFTPMEAI--------------PPQLYSqcLQTFLPGLVAWCV 255
XP_002613624 183 TSLYQLKPDAASSs---hPPPSLLEVIAEWVAGNPRICLASLKDT---------------KGTVP---VTPIPGLCHWCV 241
XP_011405071 215 TSSFPISSSSSIGha-scPPLRCIHLLSQWILTNP-DSLTTFPDTrdsPILirsqrvkrPINAP------PLMGVAQWVI 286
Q7ZTY6       188 TALYDFSTDELT------PPPALLEMLVGWITEDPRLLLLTFINSplnSSL--------PLGCLE---ITPLLGLLRWCV 250 zebrafish
XP_015215558 186 TALFDMSSDDLI------PPNDLLEMVVTWIFDDPRLTLITFLNTpisANL--------PVGCLD---LTPLVGLVRWCV 248
XP_014353234 187 TVLYDLSTDDLI------PPYDLLEMVTSWILEDPRLTLITFLNTpiaANL--------QISYLE---LTPLTGLIRWCV 249
XP_003975881 187 TTLYDLSSEELT------PPTELLQMIVFWIQEDLRLILIAFLNTpltGSQ--------PISSLD---VTPLGGLVRWCV 249 torafugu
EDO36968     291 LQPLV---------------------CLVDQEESTRDLYSELQLGILQTLvrsgrnkmnpkdememepgEVMDESDLLRH 349
XP_002040665 260 LAPLV----------------------------SNRSAYSNLHLSLLRAL--------------------QQLVSSGEST 291
EFX85120     298 EAPFNpslkkts-------pvklektKDTKSTWNENSYYSQLHSSLLESMqer--------------svLQNQQQLLQAE 356
XP_002408288 256 LAPIG----------------------SVDSTDPQAELYSYLHYALLEMLir---------------agQVTPRAPIVFP 298
XP_002613624 242 KSPLV---------------------RNPESTQEEAMIYSKLHLGILQSL-------------------LTAQNVAPNAK 281
XP_011405071 287 LEPLIpdqwivrnt----errlrgrdEEKQLVTEYRSSMSQLHANLLTYL--------------------MSLSSSPVHI 342
Q7ZTY6       251 KAPLAyhrgrks--------amtnghGDGEKGTAYEELYSKLHLSVLQVFlml-------------qvhLTEKNMFCRLT 309 zebrafish
XP_015215558 249 KAPLAykrnrkpaltnghisklskeeKEEEGVGDRDLLYSKLHLSILQVLmml-------------qvhLTEKNLFGRLG 315
XP_014353234 250 KAPLAykrnrktsltnghnaktskdlGTAM-EKDCNTLYSKLHLSVLQVFmml-------------qvhLTEKNLYGRIG 315
XP_003975881 250 KAPLAyrrdkk----------rtlpsGTGETGPDVGPLFSALHLSVLQVFmll-------------pniLNEKGLFGRLA 306 torafugu
EDO36968     350 LLKGEELHSLTSTVTSFIDNLKHnai-akGAVQEKIDLALDRLAQVLQVAIATGCLSCTRDELLAICKSLPA 420
XP_002040665 292 ALPSQDLMQIVKSLQSYCARLAEsk--tdPEADAAYQKCMERFAQAVQIALSSNCI-TNQIQLLCLLESLPP 360
EFX85120     357 VISPRHLVALVRGLLDSCAKNN--------SSNEKIQLSLDRLAQSVQVAQSSGCLYGNTHELMQALRTLPY 420
XP_002408288 299 FLPSHYVVQVAETLKRASS-----------PNSKGWDLALNRLAQVLQAAFASKCVHGNLEPMFQTLRQLPS 359
XP_002613624 282 LLPVSAVEEIVSDLRALVQTSE--------GQGEATQLAVERLAQVMQVAMATGSTQLNRKQVAGLYGQLPE 345
XP_011405071 343 AMTSTSLSSLVGRLLEFQQKTATl----lQEEKNKTELSLERLSQFLQIGLDVGIVSLNPDFLTTLLSTLPK 410
Q7ZTY6       310 VLPVESVAALIEEVGRLCEKLAP------LLDASHIQLALDRLAQALQVAMATGALLCAREDLRALCSRLPH 375 zebrafish
XP_015215558 316 LLVFDHMVQLVEELSRLVDELNP------LNATKETELSLDRLAQALQVAVASGALLCTREDLRSLCSRLPH 381
XP_014353234 316 LILFDHVVPIVEEFSRLADELNP------VHAMKEIELSLDRLAQALQVAMASGALLCTRDDLRSVCSRLPH 381
XP_003975881 307 LLQMDSLATLASELSRLLDQADKqthvsaADTQALSQLALDRLAQALQVAMANGALLCSREDLRAICSRLPH 378 torafugu
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