1F88,1JFP,3OAX,4PXF,5DGY,4X1H


Conserved Protein Domain Family
7tmA_MWS_opsin

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cd15080: 7tmA_MWS_opsin 
Click on image for an interactive view with Cn3D
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.
Statistics
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PSSM-Id: 381742
Aligned: 13 rows
Threshold Bit Score: 484.721
Created: 10-Nov-2008
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1F88: Bos taurus rhodopsin binds retinal, contacts at 4A.
  • Structure:1JFP: Bos taurus rhodopsin (dark adapted) binds retinal, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                #   #
1F88_A     38 SMLAAYMFLLIMLGFPINFLTLYVTVQHKKlrtpLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGptgCNLEGFFA 117 cattle
1JFP_A     38 SMLAAYMFLLIMLGFPINFLTLYVTVQHKKlrtpLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGptgCNLEGFFA 117 cattle
3OAX_A     39 SMLAAYMFLLIMLGFPINFLTLYVTVQHKKlrtpLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGptgCNLEGFFA 118 cattle
4PXF_A     38 SMLAAYMFLLIMLGFPINFLTLYVTVQHKKlrtpLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGptgCNLEGFFA 117 cattle
5DGY_A    198 SMLAAYMFLLIVLGFPINFLTLYVTVQHKKlrtpLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGptgCNLQGFFA 277
4X1H_A     38 SMLAAYMFLLIMLGFPINFLTLYVTVQHKKlrtpLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGptgCNLEGFFA 117 cattle
P29403     38 SALAAYMFLLILLGLPINFMTLFVTIQHKKlrtpLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGptgCYIEGFFA 117 African clawed frog
P22328     38 SALAAYMFMLILLGFPVNFLTLYVTIQHKKlrtpLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGvtgCYIEGFFA 117 chicken
P35359     38 GLLAAYMFFLIITGFPVNFLTLYVTIEHKKlrtpLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGrlgCNLEGFFA 117 zebrafish
ABS89278   38 SALAAYMFFLILTGFPINFLTLYVTVQHKKlrtpLNYILLNLAVADLFMVFGGFTTTMYTAMNGYFVFGvvgCNLEGFFA 117 Australian lungfish
AAD30519   38 SALAAYMFFLILVGFPINFLTLFVTIQHKKlrtpLNYILLDLAVADLCMVFGGFFVTMYSSMNGYFVLGptgCNIEGFFA 117 coelacanth
P79863     38 SALAAYMFFLILTGLPVNFLTLFVTIQHKKlrqpLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGpagCNFEGFFA 117 little skate
AAR14683   38 SAISAYVFTLILIGFPVNFMTLFVTFKLKKlrqpLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGptgCNIEGFFA 117 pouched lamprey
Feature 1     #  ##                                                                ### #      
1F88_A    118 TLGGEIALWSLVVLAIERYVVVCKPmSNFRFgENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGmqCSCGIDYytphee 197 cattle
1JFP_A    118 TLGGEIALWSLVVLAIERYVVVCKPmSNFRFgENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGmqCSCGIDYytphee 197 cattle
3OAX_A    119 TLGGEIALWSLVVLAIERYVVVCKPmSNFRFgENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGmqCSCGIDYytphee 198 cattle
4PXF_A    118 TLGGEIALWSLVVLAIERYVVVCKPmSNFRFgENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGmqCSCGIDYytphee 197 cattle
5DGY_A    278 TLGGEIALWSLVVLAIERYVVVCKPmSNFRFgENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGlqCSCGIDYytlkpe 357
4X1H_A    118 TLGGEIALWSLVVLAIERYVVVCKPmSNFRFgENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGmqCSCGIDYytphee 197 cattle
P29403    118 TLGGEVALWSLVVLAVERYIVVCKPmANFRFgENHAIMGVAFTWIMALSCAAPPLFGWSRYIPEGmqCSCGVDYytlkpe 197 African clawed frog
P22328    118 TLGGEIALWSLVVLAVERYVVVCKPmSNFRFgENHAIMGVAFSWIMAMACAAPPLFGWSRYIPEGmqCSCGIDYytlkpe 197 chicken
P35359    118 TLGGEMGLWSLVVLAIERWMVVCKPvSNFRFgENHAIMGVAFTWVMACSCAVPPLVGWSRYIPEGmqCSCGVDYytrtpg 197 zebrafish
ABS89278  118 TFGGIIALWCLVVLAIERYIVVCKPiSNFRFgENHAIMGVVFTWIMALACAGPPLFGWSRYIPEGmqCSCGIDYytlkpe 197 Australian lungfish
AAD30519  118 TLGGQVALWALVVLAIERYVVVCKPmSNFRFgENHAIMGVIFTWIMALSCAVPPLFGWSRYIPEGmqSSCGVDYytlkpe 197 coelacanth
P79863    118 TLGGEVGLWCLVVLAIERYMVVCKPmANFRFgSQHAIIGVVFTWIMALSCAGPPLVGWSRYIPEGlqCSCGVDYytmkpe 197 little skate
AAR14683  118 TLGGEVSLWSLVMLAIERYIVVCKPmGNFRFaTTHAALGVVFTWVMASACAVPPLVGWSRYIPEGmqCSCGPDYytlnpk 197 pouched lamprey
Feature 1              ##  ##                                                    #  ##  #     
1F88_A    198 tNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKeaaaqqqesaTTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFt 277 cattle
1JFP_A    198 tNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKeaaaqqqesaTTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFt 277 cattle
3OAX_A    199 tNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKeaaaqqqesaTTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFt 278 cattle
4PXF_A    198 tNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKeaaaqqqesaTTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFt 277 cattle
5DGY_A    358 vNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKeaaaqqqesaTTQKAEKEVTRMVIIYVIAFLICWVPYASVAFYIFt 437
4X1H_A    198 tNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKeaaaqqqesaTTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFt 277 cattle
P29403    198 vNNESFVIYMFIVHFTIPLIVIFFCYGRLLCTVKeaaaqqqeslTTQKAEKEVTRMVVIMVVFFLICWVPYAYVAFYIFt 277 African clawed frog
P22328    198 iNNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKeaaaqqqesaTTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFt 277 chicken
P35359    198 vNNESFVIYMFIVHFFIPLIVIFFCYGRLVCTVKeaaaqqqeseTTQRAEREVTRMVIIMVIAFLICWLPYAGVAWYIFt 277 zebrafish
ABS89278  198 vNNESFVIYMFIVHFTIPLIIIFFCYGRLMCTVKeaaaqqqesaTTQKAEKEVTRMVYIMVISYLVCWLPYASVSFYIFt 277 Australian lungfish
AAD30519  198 vNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKdaaaqqqesaTTQKAEKEVTRMVIVMVISFLVCWVPYASVAAYIFf 277 coelacanth
P79863    198 vNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKeaaaqqqeseSTQRAEREVTRMVIIMVVAFLICWVPYASVAFYIFi 277 little skate
AAR14683  198 yYNESYVIYLFLVHFLLPVTIIFFTYGRLICTVKeaaaqqqesaSTQKAEREVTRMVIIMVVGFLVCWVPYASFAFYLFm 277 pouched lamprey
Feature 1                   #   #                     
1F88_A    278 hqgsdfGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCM 317 cattle
1JFP_A    278 hqgsdfGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCM 317 cattle
3OAX_A    279 hqgsdfGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCM 318 cattle
4PXF_A    278 hqgsdfGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCM 317 cattle
5DGY_A    438 hqgscfGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCM 477
4X1H_A    278 hqgsdfGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCM 317 cattle
P29403    278 hqgsnfGPVFMTVPAFFAKSSAIYNPVIYIVLNKQFRNCL 317 African clawed frog
P22328    278 nqgsdfGPIFMTIPAFFAKSSAIYNPVIYIVMNKQFRNCM 317 chicken
P35359    278 hqgsefGPVFMTLPAFFAKTSAVYNPCIYICMNKQFRHCM 317 zebrafish
ABS89278  278 hqgsdfGPVFMTVPAFFAKTASVYNPVIYILMNKQFRNCM 317 Australian lungfish
AAD30519  278 nqgsefGPVFMTAPSFFAKSASFYNPVIYILLNKQFRNCM 317 coelacanth
P79863    278 nqgcdfTPFFMTVPAFFAKSSAVYNPLIYILMNKQFRNCM 317 little skate
AAR14683  278 nkgilfSATAMTVPAFFSKSSVLYNPIIYVLLNKQFRTCM 317 pouched lamprey

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