2K0S


Conserved Protein Domain Family
ARL2_Bind_BART

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pfam11527: ARL2_Bind_BART 
The ARF-like 2 binding protein BART
BART binds specifically to ARL2.GTP with a high affinity however it does not bind to ARL2.GDP. It is thought that this specific interaction is due to BART being the first identified ARL2-specific effector. The function is not completely characterized. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1.
Statistics
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PSSM-Id: 463288
Aligned: 76 rows
Threshold Bit Score: 83.786
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2K0S_A            14 EFDIVIGNIEDIIMEDEFQHLQQSFMEKYY---------LEFDDSEENKLSYTPIFNEYIEILEKHLEQqLVERIp-GFN 83  zebrafish
EAY05393          22 REDKILAAFEDVLLSDEFVEKQDEFIAKHS---------KLFTEDGDLPPECMKIYKQYAELIEKTLLAkVSKLFp-DFS 91 
XP_002952516      66 RFDCIVGALEDVLMDPEFEELREGFCRENC---------HHFEDTDENKLIYTDIFTKYTELVESTIDQkLKQAVp-GFS 135
EFX66835          17 IFDQCIGCIEEIIMSEEFLKTQHHFLTKHC---------TVFDDMEENKLIYMDIFQDYAQLVETFLEQkLREMFp-LFS 86 
XP_001847277      16 YFDTVIGHIEDIVIGEEFQTLVNQFMDCYY---------LVFEPGEENKIAYTEIYQKYQFLVETFIVEsLNDRMrnMFD 86 
EGF81369          45 LFDTIVGEIETIIMDDKFIALQQAFLSKHC---------NVFDESDENKLEYTAIFQQYNQYIESYLCKrLKVRLp-WFS 114
CBJ30390          38 RFDSIVGALEEAVMDPAFASLQQVFVDEWCgayipqqllREFEDVEENRLIYTDLFRQYTRLVERHLDGwLRQRIr-GFE 116
XP_001009521      37 EFDIIVGELQEIVISDEFEKLYKKFLIDNC---------EVFEDEEENKMEYMIIFKNYEKVIDGFIQQeLEKKIe-GFQ 106
XP_003060143      73 KFDAIVGALEELLASEAFAAAQSAFLRRHC---------DVFEDTEENKLEYTTLFDEYTSALEDAMETsLGAAVe-GFD 142
jgi:MICPUN_61197  58 KFDTIIGALEDLLMSDGFSERQAEFCRAKC---------HVFEDTEENKLEYTSIFDEYTETLEAAMMGhLDESVe-GFD 127
2K0S_A            84 MDAFTHSLkqhkde--vsgdilDMLLTFTDfmaFKEMFTDYRAEKEG 128 zebrafish
EAY05393          92 FDELIPLIknhkeediahadvfELLTATLDfneFRDLMVSYNKGQNT 138
XP_002952516     136 MQEFMLLLeshkdh--lmsevfELLLSLADfeaFKEVMLSYKRDASE 180
EFX66835          87 MEEFVKELksqpvq--legeifDILREFTDflsFKAMMLDYKTGQNS 131
XP_001847277      87 MERFARELenrrsaq-ldgeifELLYTLTDfltFKEMLLDYKSFKEG 132
EGF81369         115 MPDFLQMIkqrpdq--aegdvfDMLHSLGEfieFKDLMIGYIREKEG 159
CBJ30390         117 METFMKMVaerqge--vvddvsDILMAVGDfaeFKGMMVAHRKGRDN 161
XP_001009521     107 MNRFLELLkerhnq--ideqilDTLLSFTDfnnFKQLMLDYKKQYLE 151
XP_003060143     143 MAEFAEMLakregtgeldgdafDLLMTLSSfdaFKELMLAYKAEKHG 189
jgi:MICPUN_61197 128 AAEFFDMLeqregq--ldgdvfDLLMTLTSfeaFKELMLDYKREADG 172
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