4GMN,4GMO


Conserved Protein Domain Family
Syo1_like
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cd13394: Syo1_like 
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Fungal symportin 1 (syo1) and similar proteins
This family of eukaryotic proteins includes Saccharomyces cerevisiae Ydl063c and Chaetomium thermophilum Syo1, which mediate the co-import of two ribosomal proteins, Rpl5 and Rpl11 (which both interact with 5S rRNA) into the nucleus. Import precedes their association with rRNA and subsequent ribosome assembly in the nucleolus. The primary structure of syo1 is a mixture of Armadillo- (ARM, N-terminal part of syo1) and HEAT-repeats (C-terminal part of syo1).
Links
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Statistics
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PSSM-Id: 240521
Aligned: 53 rows
Threshold Bit Score: 305
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptide
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:4GMN: syo1 from Chaetomium thermophilum binds the N-terminal fragment of 60S ribosomal protein L5, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
4GMN_A         2 GKTRRNRVr-NRTDPIAKpvk------------------------ppTDPELAKLREDKILPVLKD------LKSPDAKS 50  Chaetomium ther...
NP_001025740   2 GKSRARRFrrVPFSPTGSe---------------------------pRREVEDGPEEEPAAELLQK------LQHPSAEV 48  chicken
NP_957183      2 GKTKNPKFkrSQFSPDGLaata----------------------vknTVEEAEDEEDSPAAELLEK------LQSPSADV 53  zebrafish
AAH14415      48 GKSRTKRFkrPQFSPTGDcqae---------------------aaaaANGTGGEEDDGPAAELLEK------LQHPSAEV 100 human
EFN62699       2 GKQKRQRHkpHKENPTGLps-------------------------vkEFELSEGITEGAKEKVLQNay--gdVQSCNLEE 54  Camponotus flor...
AEO35149       2 GKAKTKKRasRRNNPTGMps-------------------------trDIEGSELQDGNVTCSVVDNlp--ylLQSGTAEE 54  Amblyomma macul...
XP_001843480   2 GKAKKPKVhkNQLNPTGLvdvg----------------------allNQELANGKSETPIQAIVDQ------LQSASAED 53  southern house ...
XP_003708346   2 GKERRQRRkpHKENPTGLpsvkd-------------------fealeDDSKVNNVSEVALQTAYEE------IQSANVGE 56  alfalfa leafcut...
XP_643103      2 GKFTSSKKt-YRVDPLGLnlpnngfdneeldtadnlsgivaggvvgaTTDGNLIMNEDLSQSITDPiklldlISSSETVE 80  Dictyostelium d...
EHJ73656       2 GKVRKRKV--RHNAPVNNs---------------------------dEEELPVESKESAIQTIIDQ------LQVSNVEE 46  monarch butterfly

Feature 1                                                                                        
4GMN_A        51 RTTAAGAIANIVQ-DAKCRKLLLREQVVHIVLTETLTDNNiDSRAAGWEILKVLAqeeeaDFCVHLYRLDVLTAIEHAAK 129 Chaetomium ther...
NP_001025740  49 REYACASISRLLQ-QQHVIPAFLQRDVVRCLGPMLLDHSL-AVRETAAGALRNLSacggfEVCDDMVTQDIMTPLVALLK 126 chicken
NP_957183     54 REYACASISRIVQ-ENQTLPGFLQRDAVRKIGPLLLDHSL-TVRETATGALRNLSasggpEVCEDMVRQDVLTPLSALLR 131 zebrafish
AAH14415     101 RECACAGLARLVQ-QRPALPGLARRDAVRRLGPLLLDPSL-AVRETAAGALRNLSacggfEVCDDMVTKDIMTPLVALLK 178 human
EFN62699      55 KLSALQILASMSC-DSSMAKQIAKDGIAKIIGPLLMDRNA-AIQANTIHTLRDIAengreDAYNDLIKDDIMTPLTAFLK 132 Camponotus flor...
AEO35149      55 RHNAACVMANISK-DSATCRSLLKASIIRTAAPLLLDKNC-AVRHSIVGSLRNISai-nyKACEELVKFDIMTPLVCLLE 131 Amblyomma macul...
XP_001843480  54 KICGLQTLATICQ-NDVNIAAVIESEIVRIAAALLVDADN-SIRHATAGAFRNLSvl-svEICEYMVDQDVLTPLLALLN 130 southern house ...
XP_003708346  57 KLSGLQTLESMSY-DSTIAVQVATDGIAKMIGPLLIDPNA-TVRAYSASALRHIVdngktETHASLLKDDIMTPLCSLLK 134 alfalfa leafcut...
XP_643103     81 RDFAFRTISEFVLeNESFTQELIKPENIRKIITRLVEPDV-QIRVSVIGTFRNLTvv-keDICETLINLDILTPLLSNFV 158 Dictyostelium d...
EHJ73656      47 KYCGLQTFAMLLE-CPENLEQMIKRGLIKIVAPLLLDAAS-SVRNAAAGSLRNLSai-rfDLCDVLMEQDVMTSLICFFH 123 monarch butterfly

Feature 1                                                                                        
4GMN_A       130 AVLETLTtseppfskllkaqQRLVWDITGSLLVLIGLLALARD--EIHEAVATKQTILRLLFRLISaDIAPQDIYEEAIS 207 Chaetomium ther...
NP_001025740 127 ECSNGLDanqlspkkrrevnKNYVEDIANEAINLLWNVCECNS--TAVSIFNKEGCLEAVLHYIKK-FSTNVDLAISVAN 203 chicken
NP_957183    132 ECCAGFGvnsps----kkgqKTSVEDVANEAVNLLWNLCESSS--TAVSVFNKAGLVDVLLQCLQK-HPQNMELAISAAH 204 zebrafish
AAH14415     179 ECSAGLDsnemslqekkdqnRNSIENIANETVNVLWNICECSS--RAVSIFNKEGCLEIVLKYLSR-FPTNVDLAISVAY 255 human
EFN62699     133 QHSDWEPk-----------kAREEKETFIQAIDLLRILCANNE--IALKCVNEEDLVSFLIKFLDI-NIYGMEIVTIATQ 198 Camponotus flor...
AEO35149     132 EYKSPWEpves------qgkIDSKTEIFYEAVNLLWNLCENSA--TCVSVFNRERLWMVLLPCLNA-DKFGTKIATAVGC 202 Amblyomma macul...
XP_001843480 131 KYAGSEWkptfdq--nlqnqMDEKSDTFLQAVSLLWNLCESTS--VALDSFNQSQLLESFVKCLDR-NVYGKDIAVAVAQ 205 southern house ...
XP_003708346 135 NYYAEWEpksdq---dkesnVKAEEDAFIQVVTLLWTLCEHNE--DAVKIANEADIVSILKKFFDI-NTYNIEITTVTAQ 208 alfalfa leafcut...
XP_643103    159 QGINFIKtlnekd--mkqqkSIETQHVLIQAVALINNLCEVSDkgFSIVSKECKSILTTLFEVLINnSIFMPELIMNISE 236 Dictyostelium d...
EHJ73656     124 QFAENWTpdpa------sksKDEDIDTFVQCTYLLLNLCESSE--LAMKYVGDSRVLDIFCRYLDL-STFGIDIVTAILQ 194 monarch butterfly

Feature 1                                                                                        
4GMN_A       208 CLTTLSEDNl---KVGQAITDDqe----thVYDVLLKLAtgt---dpRAVMACGVLHNVFtslqwmd------------h 265 Chaetomium ther...
NP_001025740 204 CLQAVTEDNp---DLLSSFSASth-----qVLETVMMCPestmkhilLRTLIAGTIWNIKetipp--------------- 260 chicken
NP_957183    205 CLHTVTEENs---ELIRSGNAAvf----gvLDNILSSTHtsme-nilLRTLAAGSLWNLKnglss--------------- 261 zebrafish
AAH14415     256 CLQTVTEDNp---ELLKSFSATalnmlesaLLSPVSSMEsl-----lLKTLVAGTIWNLKdiipc--------------- 312 human
EFN62699     199 CMVCLSDENd---IAIKKIKQSqsi--lfnLLDLKMDDEktaskmlaLKTSVANLLININnyad---------------- 257 Camponotus flor...
AEO35149     203 CLYTASEDNaelaQCMIDFKASl------dIFQTLSEDPgi----ilLQVLSAGILVNITevqk---------------- 256 Amblyomma macul...
XP_001843480 206 CLLVISEDNaaswRILVNFGTElh-----sLLLLPDEDHpt----vlLRTVAAGIIANVPal------------------ 258 southern house ...
XP_003708346 209 CLLSLSEDNp---TAIKKLCSCeni--isrLLNLETGNNdvad-liyLKTAISGLIINIVnlmd---------------- 266 alfalfa leafcut...
XP_643103    237 FLTVVTDDNn---ELNATINNElm----lqLFNIIKDSTtmn---irLKTLISTIILNIGqlynkelviqnitpillstf 306 Dictyostelium d...
EHJ73656     195 CLFVIVEDNp---KAVDKLKNScerq-lreLLSIEGNDPsn----llIKSVAGGLTISLCggniv--------------- 251 monarch butterfly

Feature 1                                                                                        
4GMN_A       266 spgkdgACDAILIPTLTRALEHvvpggakfng------------------------------------------------ 297 Chaetomium ther...
NP_001025740 261 --gslgNMVNAILKIFSESLAIdagetiihmneaeknrlkpaagaeteeseidvtdncalse---------------ddg 323 chicken
NP_957183    262 --aqqsHTLTALASTLSHSLSLdagelipqlwraesarlskdttsvtethhtdqrpaglqveemeee------lndqkrn 333 zebrafish
AAH14415     313 --ksqaEIINALLKILSEVLGMdagemviqmkeaetqrlktaaeaeeilentngddliedd-----------------em 373 human
EFN62699     258 --snqmQMFCKMLLILSEVLAVdhkqvlaclisilphennaa-------------------------------------- 297 Camponotus flor...
AEO35149     257 --eplaAALLPIIPVLSNALSLpvfdniktlaakvelleqnvdmlt---------------------------------- 300 Amblyomma macul...
XP_001843480 259 ----aaTYSGQLLQTLAKTLEVnhrtalgtvtsslplvgqkdvaaleviedapmed------------------------ 310 southern house ...
XP_003708346 267 --ndttDIVQRVICVLSDTLSIdckqllsdltsilphkkndy-------------------------------------- 306 alfalfa leafcut...
XP_643103    307 qfnsisTLNSDLLKSLNSAKDAklkydqlvaeqtddnnnnnndekmgmdensnnnnndnnieepideskpitstvdetik 386 Dictyostelium d...
EHJ73656     252 --tlptVVLNQIIGILAQTLSVdhrlacnqlssnvplgdaagkvki---------------------------------- 295 monarch butterfly

Feature 1                                                #      #        ##                      
4GMN_A       298 ----------------------------daryanitlLALVTLASIGTDFQETLVKGNQGsrespisaadeewngfddad 349 Chaetomium ther...
NP_001025740 324 meevskgkgsgehdisdllpsdkwelkevtallmaqqTALEIIVNMCCSEDPSDDEWEELsssdesdlfmensy------ 397 chicken
NP_957183    334 ggkpnvqmsrtkndisdllprdrlelreakallsaqqTSLEIIVNMCCSDEPSDDEWEEMsssdesemcadgm------- 406 zebrafish
AAH14415     374 egishkrrvrrktfvsdllpptdkelretialltaqqTALEIIVNMCCNEDPSDDEWEELsssdesdafmensf------ 447 human
EFN62699     298 ------------------sndkrkkvqenrkilesqeQALQILANLCYEDEDSDSDIDSDidnpetidiesecldddsm- 358 Camponotus flor...
AEO35149     301 --------------veekernieqilasvldglmakqTALEILYNIVCEEDGGTEEEDCEcasddssevfdddm------ 360 Amblyomma macul...
XP_001843480 311 ---esaeqsfqrrrradlpsdvelevrnvgwllqaqrIAAEILTNICSTEEEEWQDDMDDenlseaesvhdfdaatgmn- 386 southern house ...
XP_003708346 307 ------------------sdsakkkvqtnrkilsaqqQALEILANLCVEDQENDDSNDSDindiefeidgvndvcmddk- 367 alfalfa leafcut...
XP_643103    387 ktpkniiknaaadlvqecekqfknqneewkdsllaqqSAIELFVNIVSDAQQQQPDDSNPydddddkfl----------- 455 Dictyostelium d...
EHJ73656     296 -------------pegkeamvlekqvksviqvldaqqSAIEIITNICSSEDLDEVMDGMEssdsdeptedsigegt---- 358 monarch butterfly

Feature 1                                                                     #                  
4GMN_A       350 gdamdvdqksssgedqeedyeeidvkeddedddddsitsemqadmervvgadgtddgDLEDLPTLRELIQTAVPQLIRLs 429 Chaetomium ther...
NP_001025740 398 --------------------------------------------segsgllmsplclSAEVHSAFLNNLIPKKILEKTAf 433 chicken
NP_957183    407 --------------------------------------------sdtnsslfsplclSAELHTVLLNHSMPQQVLKKAEf 442 zebrafish
AAH14415     448 --------------------------------------------secggqlfsplclSHEVHTALTNYLIPKKIFEKTAf 483 human
EFN62699     359 --------------------------------------ndnlkitstfpvelievvsNCNLIDKIWDKTELVVDKDSQEi 400 Camponotus flor...
AEO35149     361 --------------------------------------------eteessdvhplniSCELHKALVENYIAPEVLDHVSe 396 Amblyomma macul...
XP_001843480 387 ---------------------------------------dslqntdklpvevleaikTMSLVEKLWQKAQPIAENVREIl 427 southern house ...
XP_003708346 368 ---------------------------------------lynktssslspeiievfnSCNTLKKVWDKTVAVDKDTAEIl 408 alfalfa leafcut...
XP_643103    456 ------------------------------------------------diedgeteqSQQILSNISKFIISTPLCQYLIe 487 Dictyostelium d...
EHJ73656     359 -----------------------------------------llpedklppellealiSLEIYDKIWARTQLPPENVMSIl 397 monarch butterfly

Feature 1                                           #  ##  ## ###         #                      
4GMN_A       430 nlp------------------idsdESLTIQSHALSALNNISWTISCLefangenanIHNAWYPTAKKIWRKtilpilea 491 Chaetomium ther...
NP_001025740 434 pnsvaldicv-----hnpswkplikKMNTVQCRALTCLHSILLVSDVDclgg--asaLQSLAQHLSQLIFSKtel----- 501 chicken
NP_957183    443 psaaalelcs-----kdsswkcllkKMQRVQCRALTCLHNILSSMDTDslgg--assLQAVAQHLSSLVFSSaev----- 510 zebrafish
AAH14415     484 pnsiavdlcs-----rnptwkplirKMNTIQCRALFCLQSLVSLLDVEhlgg--aaaLQTLAQHLSQLLFSQpdf----- 551 human
EFN62699     401 lnqtte-------------gkavikQFHDIRCAAYLCLNNLLSSIEIDvfgg--idnLYRKWLEIGTAIFKDvts----- 460 Camponotus flor...
AEO35149     397 ldktiskvll-----rhkpssvvlkRVHSVRCRALLCLGNLADTLNPAafgg--isgLASTWTCLASLLFHNids----- 464 Amblyomma macul...
XP_001843480 428 eend----------------rnlvkRVNNLRAAAMLCLHNLCNNITVEdlgg--aeaVYTVWLELGQQVFQGqq------ 483 southern house ...
XP_003708346 409 eqnve--------------geavlkQMHILNCRAYLCLNNLISCLEMDtlgg--ienIYRMWCNIGTVVFKDanp----- 467 alfalfa leafcut...
XP_643103    488 llnsivnfdstefgklniellpnisSIRILQKRAMTCLSNLLITFIPKee-----nvQKILWDLLMKIANKSftt----- 557 Dictyostelium d...
EHJ73656     398 keyeg--------------tqlvskKLYSLQTRSLLCVNNMIMTLPLDnlgg--ingVYKIWVDAGKLVFKNns------ 455 monarch butterfly

Feature 1                       #   #                                                    #    #  
4GMN_A       492 dsadLKLATQVTSLAWAVARVlhget-----------ptdgnPHRKFISLYHsskqqaggnsnsieepedpfQGLGVKCI 560 Chaetomium ther...
NP_001025740 502 -pedTEFLEAITSALRALLQTmaskn-----------isqcmTPEQLLALCEasih-------------ssnASVRVNVV 556 chicken
NP_957183    511 -lkdEEFLEAVTSALRSLLQImatkn-----------isqcmTPHQLMGFCEaats-------------cdlVSVKVNAL 565 zebrafish
AAH14415     552 -akhVDFLEAISSALRALLQTmaskn-----------isqcmTPDQLMTLCKagih-------------ssnVGVRVNVV 606 human
EFN62699     461 --ndIELLEAATAAMRAILQQlaevra---------nvfkqlTVDDCQPMLNgvrq-------------csnANVRVNLI 516 Camponotus flor...
AEO35149     465 --keLDLLEASTSACRSVLQAlasaatrgea--sntrylpnvTDEELEVLAQvglq-------------cseLHVRTIMT 527 Amblyomma macul...
XP_001843480 484 ---nPKLLEASTSLMRATLEHlrkspe----------lfkqmTESDLQLMLNgvne-------------cqdSEIRANWL 537 southern house ...
XP_003708346 468 --ddTELLESATAAMRAALEKlseaev---------nvfnqlTLNDIHPMLNgerq-------------ckdPNIRVNLL 523 alfalfa leafcut...
XP_643103    558 --ndIDIIEMTTSSLWSIMRTnsni--------------gftTEIEIKNLVElai--------------kspNSIKTNLI 607 Dictyostelium d...
EHJ73656     456 --nnFDILESATAVMRAALDKlqgyysakdrklddnnlfkdlALSDIEIMLTgird-------------cqvPEIRSNLI 520 monarch butterfly

Feature 1                                                                                        
4GMN_A       561 GVVGSLAhd------paPIEVNREVGVFLVTLLRQSNnvPPAEIVEALNQLFDIYGDEelacdkevfWKDGFLKHLEEFL 634 Chaetomium ther...
NP_001025740 557 SILGISGsvla--kvqdTAETLKMIGKFLLEVAMKES--SLVVAGEALDALFDVFADVkeae--kaaVQMKLLPALKEFQ 630 chicken
NP_957183    566 AILGITGssla--kdknTADTLQLIGNALLNVATKDA--NLVVCGEALDALFDVFADGdeae--kaaKNIDLLSSLKALQ 639 zebrafish
AAH14415     607 SILGITGsvla--kedgTLETLKNIGCFLLEVTTKDP--SLVVAGEALDALFDVFADGkeae--rasIQIKLLSALKEFQ 680 human
EFN62699     517 RMLCNLVqilmnnknseDYEMIKFISTFLLNICTTET--QAWIIAESIDAIMDIYAEDet------dCLAAEIELVPKLL 588 Camponotus flor...
AEO35149     528 RIMATLAcll----gpqRTDVLKRVGQYLLEVCVKDT--DIRVVTEALDATFDVFAEDtt------dAVAAEIGLVTKLR 595 Amblyomma macul...
XP_001843480 538 RMLGILGcl-------lPEPLIKLIIDFVLVTCLKEQ--DLWTVSEAMDSMMDIFADNdw------pQLVYELGMPAKCK 602 southern house ...
XP_003708346 524 RILGNLAtvltrnnvteSSELIKHISIFLLDTCLNES--KVWVMAECMDAIMDIYAEDds------dKIASETKLIERLY 595 alfalfa leafcut...
XP_643103    608 GIIGIAGqk------pyCQNILKEVAMFLLQCLNKDL--PADIISESLNSIFDIYAEPnvn---nivKEVSLIQHLDAFV 676 Dictyostelium d...
EHJ73656     521 RMIGTMAlllvnnlndiTTNVIITITEFIIEQAHKEN--EVWVLAEAIDTIVDLYSEDet------dSLAAKIKLGDKLS 592 monarch butterfly

Feature 1                          #   #                  
4GMN_A       635 PKMRTLTKGIDKRTQ--PELRTRADEALLNLGRFVQYKKKH 673 Chaetomium thermophilum var. thermophilum DSM 1495
NP_001025740 631 PMFKMRIRKEGKGQYs-TDQLCVLDNVKMNLRRFIAYQETL 670 chicken
NP_957183    640 PGFRAKLRKEGKGKYs-PDQLCVLDNIRINLKRFIGYLENL 679 zebrafish
AAH14415     681 PVFKMKIRKEGRGNYs-TDQLCVLDNVKMNLRRFIAYQETV 720 human
EFN62699     589 SIIPHFKSKVRQQKKqlKDNMSVVSTVNANLTRFIKYKQKQ 629 Camponotus floridanus
AEO35149     596 QMLPAFKSKVNEAKKtlVHHYPVIATIKTNLVRFIEYKAQR 636 Amblyomma maculatum
XP_001843480 603 ELDRIMKAKLKQSKRelNERYPAVCTVRTNLSRFCKYLEAE 643 southern house mosquito
XP_003708346 596 GLVPLFKDKMRQQRKtlGDNIAVVSTVKNNIMRFIKYKEKR 636 alfalfa leafcutting bee
XP_643103    677 PIIRNKIKTDKKKLD--RALLDRLDESRINLSRFITYKKSQ 715 Dictyostelium discoideum AX4
EHJ73656     593 MLAPILKNKARQQKKlpKEYKVLVATANSNLPRFIKYLKGR 633 monarch butterfly

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