Conserved Protein Domain Family
STKc_Nek4
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cd08223: STKc_Nek4 
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270862
Aligned: 10 rows
Threshold Bit Score: 500.041
Created: 15-Dec-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of MgADP to human Nek2
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            ## ##   #            # #                              #                 #
P51957      5 AYCYLRvVGKGSYGEVTLVKHRrDGKQYVIKKLNLrnASSRERRAAEQEAQLLSQLkHPNIVTYKESWEGgdgLLYIVMG 84  human
AAH54633    3 GYLFVRvVGKGSYGEVNLVRHKsDRKQYVIKKLNLrtSSRRERRAAEQEAQLLSQLkHPNIVMYRESWEGedcQLYIVMG 82  zebrafish
AAH68778    9 EYVLVRpVGKGSYGEVSLVRHRtLGKQFVIKKLNLqnASRRERKAAEQEAQLLSRLkHPNIVAYRESWEGedgMLYIVMG 88  African clawed frog
XP_414252   5 AYCFLRaVGKGSYGEVSLVRHRqDSKQYVIKKLNLkhASSRERKAAEQEAQLLSQLkHPNIVAYRESWQGedgLLYIVMG 84  chicken
EEN58813    5 EYQKVQvVGKGSYGEVWLSRHQkDRKQYVLKRMDLqnASKRERKAAEQEAKLLSKLrHPNIVNYKDSFETeegMLYIAMG 84  Florida lancelet
EDO49690    5 RYTIGKcIGKGSYGEVFLSKHKkDKKQYVLKKVDLqkASVRERKAAELEAKLLSQLrHPNIVSYRESFQDdtgFLYIAMN 84  starlet sea anemone
EKC37451    6 QFEFIRqIGKGSYGEVTLQRHKkDRKQYVLKRINLkkASKREQHAAEQEAKLLSKLkHPNIVTYKDSFQGkdgYLHIAMQ 85  Pacific oyster
EDV24761    5 SFNVLKqIGKGSYGEVFLVRHKrGNKKYVMKKIQLknASTRERKAAQQEALLLKKLiHPNIVSYKDSFQDrtgYLYIIMG 84  Trichoplax adhaerens
ELT92847    5 LYDKKNvIGKGSYGEVWLVRHKrDKKQYVLKKMELlnASKRERKAAEQEAKLLSKLkHPNIVSYKDSFECengFVYIVMG 84  Capitella sp. I Gr...
CCD78918    8 DYQFIKtIGKGSYGEVWLCRHKtDTKKYVIKKIDVtkSSDKERKAAKLECRLLSEFrHPNIVQYKTSFEYh-gFLYIAMG 86  Schistosoma mansoni

Feature 1     ##   #                                             # #               #          
P51957     85 FCEGGDLYRKLKeQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTrtNIIKVGDLGIARVLENHCDMAS 164 human
AAH54633   83 FCEGGDLYHRLKqQKGELLPERQVVEWFVQIAMALQYLHEKHILHRDLKTQNIFLTktNIIKVGDLGIARVLENQNDMAS 162 zebrafish
AAH68778   89 FCEGGDLYHKLKeQKGKLLLESQVMDWFIQIAMALQYLHEEHIMHRDLKTQNVFLTrsNIIKVGDLGIARVLESQYDMAS 168 African clawed frog
XP_414252  85 FCEGGDLYHRLKeQKGKLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTrtNIIKVGDLGIARVLENQCDMAS 164 chicken
EEN58813   85 FCEGGDLYTRLKnQKGVLLEEEQVVEWFVQITMALQYLHERNILHRDLKTQNIFLTktKIIKVGDLGIARVLDSSSDMAT 164 Florida lancelet
EDO49690   85 FCEGGDLYSRLKaQKGIPLDENQIVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTksKIIKVGDLGIARVLESSSDMAT 164 starlet sea anemone
EKC37451   86 FCEGGDLYTKLKeQKGVPLEERQVVEWFVQIAMALQYMHERNILHRDLKTQNIFLTksKIIKVGDLGIARVLESSSDMAT 165 Pacific oyster
EDV24761   85 FCEGGDVYNYLKnRNGLPIDESQVMVWFMQIALALQFMHSNNILHRDLKTQNIFLTkhDIIKVGDLGIARVLEGSWDLAT 164 Trichoplax adhaerens
ELT92847   85 YCEGGDLYARLKeQKGVPLEERQVVEWFVQITMALQYMHERNILHRDLKTQNIFLTksKIIKVGDLGIAKVLESSSDMAS 164 Capitella sp. I Gr...
CCD78918   87 FCEGGDLYTRLRmRNGVLLSERVLVEWFVQLAIALQYMHERNVLHRDLKTRNIFLTrsNIVKLGDLGIARVLESSNSMAT 166 Schistosoma mansoni

Feature 1                                                                                     
P51957    165 TLIGTPYYMSPELFSNKpYNYKSDVWALGCCVYEMatLKHAFNAkdMNSLVYRIIEGKLPPMPRdYSPELAELIRTMLSK 244 human
AAH54633  163 TLIGTPYYMSPELFSNKpYNYKSDVWALGCCVYEMatLKHAFNAkdMNSLVYRIVEGKLPQMPSkYDPQLGELIKRMLCK 242 zebrafish
AAH68778  169 TLIGTPYYMSPELFSNKpYNYKSDVWALGCCVYEIatLRHAFNAkdMNSLVYRIIEGKLPPMPKdYTKELGDLIAAMLNR 248 African clawed frog
XP_414252 165 TLIGTPYYMSPELFSNKpYNYKSDVWALGCCVYEMatLKHAFNAkdMNSLVYRIIEGKLPPMPKdYSPQLVEIIQTMLSK 244 chicken
EEN58813  165 TLIGTPYYMSPELFSNKpYNHKSDIWALGCCVYEMatLKHAFNAkdMNSLVYKILRGKMPSMPKkYSTDLCDLIKLMLAQ 244 Florida lancelet
EDO49690  165 TLIGTPYYMSPELFSNKpYNHKSDVWALGCCLYEMctLRHAFNAkdMSSLVYKILKGKTPPLPKqYSTDLCSIIKSMLDQ 244 starlet sea anemone
EKC37451  166 TLIGTPYYMSPELFSNKpYNHKSDVWALGCCVYEMatLKHAFNAkdMNSLVYKILKGKMPLMPKqYSPELIQIIKNMLHQ 245 Pacific oyster
EDV24761  165 TRVGTPYYMSPELFSNQpYNHKSDVWALGCCVYEMltLKHAFSAkdLNSLVYKILNGKVPQMPKqYSTQLGDIVKSTLAL 244 Trichoplax adhaerens
ELT92847  165 TLIGTPYYMSPELFSNKpYNYRSDVWALGCCVYEMttLKHAFNAkdMNSLVYKILRGKMPAMPKsYSPELVSLIKAMMNH 244 Capitella sp. I Gr...
CCD78918  167 TLIGTPYYMSPELFANKpYNHKSDIWALGCVLYEMstLRHAFNAksFNALSYKILSGKIPDMPTqYSPELLELMRAMLHL 246 Schistosoma mansoni

Feature 1                         
P51957    245 rPEERPSV---RSILRQPYI 261 human
AAH54633  243 kPEDRPDV---KHILRQPYI 259 zebrafish
AAH68778  249 qPEKRPSV---KQILHKSFI 265 African clawed frog
XP_414252 245 rPEQRPSV---KSILRQPYI 261 chicken
EEN58813  245 dPEKRPSS---KRVLRNPYI 261 Florida lancelet
EDO49690  245 dPDKRPSA---SRLLRHPYI 261 starlet sea anemone
EKC37451  246 ePEKRPSSvpqPAILRKKGH 265 Pacific oyster
EDV24761  245 dPKNRPSV---PQLLRLPYM 261 Trichoplax adhaerens
ELT92847  245 nPDKRPSV---NRILRDPYI 261 Capitella sp. I Grassle & Grassle, 1976
CCD78918  247 kPEKRPSA---RRVLSNSFI 263 Schistosoma mansoni

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