Conserved Protein Domain Family
TGF_beta_GDF10
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cd19394: TGF_beta_GDF10 
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins
GDF10, also termed bone morphogenetic protein 3B (BMP-3B), or bone-inducing protein (BIP), is a growth factor involved in osteogenesis and adipogenesis.
Links
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Statistics
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PSSM-Id: 381664
Aligned: 6 rows
Threshold Bit Score: 242.126
Created: 19-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens BMP-3 (2QCQ) forms a homodimer.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      # #   ## #         # ###                ##  ## ##  #    ###  # ## 
P55107       367 RKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPD 446 human
Q7T2X6       332 RRQWDEPRVCSRRYLKVDFADIGWSEWIISPKSFDAYYCSGACEFPMAKVVRPSNHATIQSIVKAVGIIPGVPEPCCTPD 411 African clawed ...
XP_007902779 347 RRQWNQPKICSRRYLKVDFADIGWSEWILSPKSFDAYYCAGACEFPIPKVVRPSNHATIQSIVKAVGIIPGIPEPCCVPD 426 elephant shark
XP_005992509 343 RRQWNEPRFCSRRYLKVDFADIGWSEWIISPKSFDAFYCAGACEFPMPKIVRPSNHATIQSIVKAVGIIPGVPEPCCVPD 422 coelacanth
XP_015266059 275 QKQWSEPTVCSRRYMKVDFADIGWNEWVISPKSFDAYYCAGGCKFPMPKIVRPSNHATIQGIVKAVGIIPGIPEPACVPN 354 Gekko japonicus
ACA57845     312 RKQWSEPRVCTRRYLRVDFADIGWSEWILAPKAFDAYYCAGTCAFPIPKVVHPSNHATIQSIVRAVGIVPGVPDPCCVPD 391 zebrafish

Feature 1         #                   ### #     #
P55107       447 KMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478 human
Q7T2X6       412 MMNSLSVLFLDEGRNMVLKVYPNMSVESCSCR 443 African clawed frog
XP_007902779 427 KMNALSVLFFDENKNVVLKVYPNMSVETCACR 458 elephant shark
XP_005992509 423 KMNSLSVLFLDENKNVVLKVYPNMSVETCACR 454 coelacanth
XP_015266059 355 AMNSLSVLFRDRSDNLVLKVYPNMSVDSCACR 386 Gekko japonicus
ACA57845     392 KMSSLAVLFLDSSRNMLVKIYPSMSVETCACR 423 zebrafish

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