1UUH


Conserved Protein Domain Family
Link_domain_CD44_like
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cd03516: Link_domain_CD44_like 
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This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.
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Statistics
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PSSM-Id: 239593
Aligned: 8 rows
Threshold Bit Score: 155.696
Created: 6-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative hyaluronan-binding site [chemical binding site]
Evidence:
  • Comment:These residues were identified by site-directed mutagenesis as critical or important for HA binding.
  • Citation:PMID 9417085
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #   ##                         #         ##                         
1UUH_B         7 ITCRFAGVFHVEKn-gRYSISRTEAADLCKAFNSTLPTXAQXEKALSIGFETCRYGFIe------GHVVIPRI-----HP 74  human
AAH26231      34 VSCRIMGITLVSKk-aNQQLNFTEAKEACRLLGLSLAGKDQVETALKASFETCSYGWVg-----dGFVVISRI-----SP 102 human
NP_444477     33 STCRIMGVALVGRn-kNPQMNFTEANEACKMLGLTLASRDQVESAQKSGFETCSYGWVg-----eQFSVIPRI-----FS 101 house mouse
AAQ85130      34 GPCRIMGVTLVTKk-tQPLLNFTEAQEACRLVGLTLASQDQVEEARKFGFETCSYGWVk-----nQFVVIPRI-----IS 102 cow
AAH74228      32 ISCRFKGVFHVEKn-dRYSLNQEDAVKLCGMLNTTIASYAQLEIALDFGFETCRYGWIe------DRVLIPRI-----KP 99  African clawed ...
AAD37443      26 ITCRYGGVFHVEKn-gRYSLTRAEAIELCRALNSTLATLEQFERAHALGFETCRYGFIv------GHIVIPRI-----NP 93  chicken
XP_001379514  43 DPCRIMGITLIGKg-kGPELNFTDASDACSLLGLQLASKAQVTTAKDFGFETCSFGWVs-----dKYVVISRI-----LP 111 gray short-tail...
XP_699576     31 LNDGVSGVFLIQTktsTYSFDAITAKEACEAIKMRIAKKTEVETANKNGLQTCRFYLFicavcnkGVEYIKRLalrwvDV 110 zebrafish

Feature 1              ##        #                                                               
1UUH_B        75 NSICAANN-----TGVYILts----ntSQYDTYCF-NASAPPEEDCtsvtdl-------------pnafdgPITITivn- 130 human
AAH26231     103 NPKCGKNG-----VGVLIRkvp---vsRQFAAYCY-NSSDTWTNSCipeii----------------ttkdPIFNTqta- 156 human
NP_444477    102 NPRCGKNG-----KGVLIWnap---ssQKFKAYCH-NSSDTWVNSCipeiv----------------ttfyPVLDTqt-- 154 house mouse
AAQ85130     103 NPKCGKSG-----VGVVIWrss---lsSRHRSYCH-NSSDIWINSClpeii----------------ttddPLFNTeta- 156 cow
AAH74228     100 NPICAANY-----TGIYTLgnn---esLRYDVYCY-NASETEDKSClpvlllnetd-----fshntidsydPTLDTqiqn 165 African clawed ...
AAD37443      94 YHLCAANH-----TGIYKLsan---ttGRYDAYCY-NATETRSKACepie-----------------ridiTFLSNqsei 147 chicken
XP_001379514 112 NPKCGKNK-----IGVLEWnlk---lqKEQYAYCY-NSSDTWINSCkpeav----------------tteeDITILptvl 166 gray short-tail...
XP_699576    111 VHLALYNLgvqskKKYFELeeivafinNNWDRFQMgKLSNTPLPERgqlildalnnykskflcgkeikkrkCIFRLr--- 187 zebrafish

Feature 1                                    
1UUH_B       131 ----rdgTRYVQkgey---rtnPEDIYP 151 human
AAH26231     157 ----tqtTEFIVsdsty-svasPYSTIP 179 human
NP_444477    155 -----paTEFSVsssay-lassPDSTTP 176 house mouse
AAQ85130     157 ----tytTKLMVsdsthselstDGPDYV 180 cow
AAH74228     166 ----sdkSGYQGdsvt---dpaPAMITP 186 African clawed frog
AAD37443     148 vidnedgSRYNAdgtr---hsgDSSTSG 172 chicken
XP_001379514 167 ---dtteTEHNVsvtadttttsPALPPN 191 gray short-tailed opossum
XP_699576    188 -------TRVPPn--------pPSKLYP 200 zebrafish

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