3ICQ,4HB3,7B51,5YU6,3ZJY


Conserved Protein Domain Family
Xpo1
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pfam08389: Xpo1 
Exportin 1-like protein
The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.
Links
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Statistics
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PSSM-Id: 462459
Aligned: 52 rows
Threshold Bit Score: 56.8473
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3ICQ_T  103 PAYISNAVQHLLTLLFLQLYPSNWNDFFASLQgviAASSQ---------SEFSNFYLKVLLSIGDEIADslVLKTDVQIQ 173  fission yeast
Q5SPJ8   98 KPFIRNKAAQVFALTFVMEYLTLWPKFFFDVL---ALVGLn--------PNGVDIYLRTLMAIDAEVVDrdILHSPEETR 166  zebrafish
O43592   98 KTFIRNKAAQVFALLFVTEYLTKWPKFFFDIL---SVVDLn--------PRGVDLYLRILMAIDSELVDrdVVHTSEEAR 166  human
Q7PC79  106 PPFVKNKLAQVLATLIYYEYPLIWSSVFLDFMl--HLCKG---------AVVIDMFCRVLNALDDELISldYPRTPEEIS 174  thale cress
Q8H3A7  103 PPFLRNKLAQLLALLVRFEYPHVYPSYFLDLI---PPSPPl--------PGPTDMFARVLVSLDDDLLSqdYPRNAEEAS 171  Japanese rice
Q5CYM5  121 QSYLKNKISELYVTMIYADYPENWPSAFLDIV---SLVTAh--------DWMPDMFIRILCTFDKMIVSniGLQSAEDIS 189  Cryptosporidium parvum
Q6C715  112 PVHMKNKLGETLAYLFIMTYTEIWDTFFYDFE---RLLESpenq--fgnPRAADLYLRVLNDIHREIGDtlIIRDPAVQS 186  Yarrowia lipolytica...
Q7RWV9  103 PANVQNKLTQTLTYLFVALYGEGWETFFDDFL---ALTSSqnga-srdnLSGVMLYLRILSSVHDEIADlmISRQGNESK 178  Neurospora crassa O...
Q5ASE3  102 PPNIQNKIAQTITFLFSALYGNGWESFFDDLL---SLTHKspssttrdnPLGIIFYLRVINSIHDEIGDvlVSRSRAEQE 178  Aspergillus nidulan...
Q6BL58  102 PVYLKNKFAGIMGNLFCFTYLSINPTFLKDLL---ALIADn-------nLIAIDIYSRIIIAVHTEISDkfISRSREVQD 171  Debaryomyces hansen...

3ICQ_T  174 KDNLVKDAIRANd-MSDIVSFVYEMMLAYSNAKn----YGTVGLCLQVYAQWVSWININLIVNEPCMNLLYSFL----QI 244  fission yeast
Q5SPJ8  167 RNTLIKDGMREQc-IPALVESWFQILQTYQHTH-----SELTCQCLEVVGAFVSWIDLNLIANDRFVNLLLSHM----SM 236  zebrafish
O43592  167 RNTLIKDTMREQc-IPNLVESWYQILQNYQFTN-----SEVTCQCLEVVGAYVSWIDLSLIANDRFINMLLGHM----SI 236  human
Q7PC79  175 VAARVKDAMRQQc-VPQIARAWYDIVSMYKNSD-----PDLSATVLDCMRRFVSWIDIGLVANDAFVPLLFELIlsdgLS 248  thale cress
Q8H3A7  172 DAGRVKDAMRAQc-VPQIARHWHEAAVSLRAAD-----PAVAAVALDAARRCISWIDVSLVANDVFVPLLFDIAlspgSV 245  Japanese rice
Q5CYM5  190 IRRKIKDIMRVNgdLNHIVQAWIFVVSKHKSQSltkdrIQLLSSSMKMMESFIDWIDISYAVNNEVLSIILSFL----NP 265  Cryptosporidium parvum
Q6C715  187 RNNDLKDLIRNRd-MARLADSWKKILMYYKDQQleplaTEIVNNALRVIGGWVSWAELTLIAEPEALEAIFNLL----SS 261  Yarrowia lipolytica...
Q7RWV9  179 RNNDLKDLIRERh-MQKIAMSWQDILAQWTNKH-----DGVVELTLKVIGKWVSWIDISLVVSQDMQNLILPLV----GR 248  Neurospora crassa O...
Q5ASE3  179 RANALKDLIRVRd-MQKIASSWQEILSQWMDGD-----DLIVEMSLKAVGSWVSWIDIGLVVNQTMLDLLFQQL----GR 248  Aspergillus nidulan...
Q6BL58  172 RNNLLKDQIRTNd-MNLLVDNWQKILRNPELIQh---nNEVLNNFLKIIGYYINWMEITLFISNDFINIIFQYL----NK 243  Debaryomyces hansen...

3ICQ_T  245 EEL----------RCAACETM 255  fission yeast
Q5SPJ8  237 EEL----------REAACDCL 247  zebrafish
O43592  237 EVL----------REEACDCL 247  human
Q7PC79  249 EQV----------RGAAAGCV 259  thale cress
Q8H3A7  246 APL----------AAAAVGCL 256  Japanese rice
Q5CYM5  266 IDSp--------vVVETLNFL 278  Cryptosporidium parvum
Q6C715  262 PKS----------RIHACDCL 272  Yarrowia lipolytica CLIB122
Q7RWV9  249 VNNtsnn--idtvRDTAIDTL 267  Neurospora crassa OR74A
Q5ASE3  249 AQKaelregedkvRDAAVDVF 269  Aspergillus nidulans FGSC A4
Q6BL58  244 PDQ----------RNETCLTL 254  Debaryomyces hansenii CBS767
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