3S8P,5WBV,4BUP,5CPR


Conserved Protein Domain Family
SET_KMT5B
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cd19184: SET_KMT5B 
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
KMT5B (also termed lysine N-methyltransferase 5B, lysine-specific methyltransferase 5B, suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1 or Suv4-20h1) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.
Links
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Statistics
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PSSM-Id: 380961
Aligned: 10 rows
Threshold Bit Score: 283.464
Created: 12-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus Suv4-20h2 (4AU7) in complex with histone H4 peptide and SAH.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #     ##                                      ########    #  #   ####
3S8P_A       130 DSGFEILPCNRYSSEqNGAKIVATKEWKRNDKIElLVGCIAELSEIEENXLLRHGENDFSVXYSTRKNCAQLWLGPAAFI 209 human
5WBV_A       130 DSGFEILPCNRYSSEqNGAKIVATKEWKRNDKIElLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 209 human
Q5U3H2       167 DSGFEILSCNRYSSEqNGAKIVATKDWKRNDKIEhLVGCIAELSPSEERMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 246 zebrafish
4BUP_A       128 DSGFEILPCNRYSSEqNGAKIVATKEWKRNDKIElLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 207 house mouse
5CPR_B       125 DSGFEILPCNRYSSEqNGAKIVATKEWKRNDKIElLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 204 human
Q4FZB7       192 DSGFEILPCNRYSSEqNGAKIVATKEWKRNDKIElLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 271 human
OPJ73725     160 DSGFEILPCNRYSSEqNGAKIVATKEWKRNDKIElLVGCIAELSEMEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 239 Patagioenas fas...
NP_001088653  98 SSGFEILPCCRYSSErNGAKIVATKDWKRNDKIElLVGCIAELSEAEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 177 African clawed ...
XP_005988066 192 ESGFEILPCNRYSSEkNGAKIVATKEWKRNDKIElLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 271 coelacanth
XP_007885786 131 ESGFELLPCNRYSSEqNGAKIVATREWKKNDKIElLVGCIAELSEMEENMLLRHGENDFSVMFSTRKNCAQLWLGPAAFI 210 elephant shark

Feature 1        ##       # #                       #  ###      ###              
3S8P_A       210 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR 273 human
5WBV_A       210 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR 273 human
Q5U3H2       247 NHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSK 310 zebrafish
4BUP_A       208 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR 271 house mouse
5CPR_B       205 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR 268 human
Q4FZB7       272 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR 335 human
OPJ73725     240 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEYCECYTCERRGTGAFKSR 303 Patagioenas fasciata monilis
NP_001088653 178 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRATGAFKSR 241 African clawed frog
XP_005988066 272 NHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEYCECYTCERRGTGAFKSK 335 coelacanth
XP_007885786 211 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGQGAFRSR 274 elephant shark

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