6G18,6ZXF


Conserved Protein Domain Family
WRNPLPNID

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pfam15017: WRNPLPNID 
Putative WW-binding domain and destruction box
This short conserved region is a putative destruction-box, with its RxxLxxI sequence motif, though the homology is not absolute. The domain occurs on a number of tumourigenic proteins, on some RNA-binding proteins and serine-threonine regulatory proteins. The second less well-conserved motif, WITPS, is a potential WW domain ligand-binding motif for recruiting proteins to their substrates. WW domains bind tightly to short proline-containing peptides that are typically in regions of native disordered polypeptide, as this family is as it lies between a PIN domain and a zinc-binding domain.
Statistics
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PSSM-Id: 464448
Aligned: 33 rows
Threshold Bit Score: 30.004
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6G18_y       152 LEFSSFMFWRNPLPNIDH-ELQELLidr------------------gedVpseeeeeeeNGF-------EDRKDDSDdDg 205
EEN48324      39 EDFTDFTFWRDPLPLLSEdDF---------------------------------------------------NTVDPaPe 67 
XP_006005166   7 SQYNSFLFWRQPIPELDLaELEGLGltdalmhnp------ksagrkksdL---------REN-------SKEEEEYl-Sl 63 
XP_002937308   7 SQYDSFLFWKLPIPELDLsELECLGledskt------------rraktsA---------DQK-------KKEDGEEYlSq 58 
NP_001183990   7 SQYSSFLFWRMPIPELDLsELEGLGlsdtptykmkds-sagnvtgqapgA---------ERE-------KNLEGDAl-Le 68 
XP_012405176   7 SQYSSFLFWRMPIPELDLsELEGLGlldmstyktrnnsndgnlsekpseA---------VQQ-------KYPENDPl-Le 69 
XP_007485468   7 SQYSSFLFWRMPIPELDLsELEGLGlldmaiyktpnssngkltkeepsgA---------DQK-------SGPESDAl-He 69 
XP_007230860   7 SQFDSFLFWRQPIPSLDLaELEDLGlsvlpnsg---------qmgktnkG---------MGKt-----lADEDDDPNlSe 63 
A3KQS5         7 SQFDSFLFWRQPIPSLDLsELEDLGisa------------------pksK---------EMKstksfprQDEDEDRElSk 59  zebrafish
XP_015192187   7 SQYDSFLFWRQPIPELDLsELEGLGlvdgvsikgsq---ggkkqkssqnS---------RQW-------EEEEDEGl-Sk 66 
6G18_y       206 ----gGWITPS 212
EEN48324      68 fndfnYWREPI 78 
XP_006005166  64 ystfnFWRAPI 74 
XP_002937308  59 ynafnFWRAPI 69 
NP_001183990  69 ystfnFWRAPI 79 
XP_012405176  70 ystfnFWRAPI 80 
XP_007485468  70 fstfnFWRAPI 80 
XP_007230860  64 ystfnYWKEPI 74 
A3KQS5        60 fstfnFWKEPI 70  zebrafish
XP_015192187  67 yntfnYWREPI 77 
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