Conserved Protein Domain Family
CENP-P
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pfam13096: CENP-P 
CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P
CENP-P is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.
Links
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Statistics
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PSSM-Id: 289841
Aligned: 3 rows
Threshold Bit Score: 307.562
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q1LV50       101 QQLRLAGHCGLLLFQVEFAVTEIQEDNVLHRRVTELNIVVDGVEFKDFSAFVSRVEDTKDLLLFFRTLRTFSERCEDRRQ 180 zebrafish
Q1T7B7       105 QKHRLSGNCQSLPFSLEFQLLEVQNKENVSAAITDLSIAIESGQHSELSKFVSRAEENGNLLMFFRNLSSYAEWCEHRRC 184 chicken
XP_004004127 103 QKHRLSGNCHMITFQLEFQILEIQDKESLSSVITDLSIIMEPTEYSELSEFVSRAEEKRDLLMFFQSLRFFVEWCDYRKR 182

Q1LV50       181 TFQHFQEKYPDVVNLPEGCRSEIMIIRSPQLPGISMTLFWKIHVSKEGVVKPLLDLLLKMPDQALElDTKKVMEKGSDYF 260 zebrafish
Q1T7B7       185 TFLHFKAKYPNIVTLPEGQEGDHIILRNPQLPGFELMIVWKMHIDEEGTTTPVLDLLPKVPQQALE-QKKASIDNAPACF 263 chicken
XP_004004127 183 TFKHFKEKYPEAVQLSEGASSSCMGIRNPSQPGFELVIVWKIQIDEEGKVLPKLDLLTEVPLRALElDKNGVIETAPLSF 262

Q1LV50       261 QSLLQLLGVEASIEGLI 277 zebrafish
Q1T7B7       264 RSMLLLFGIETAIENLI 280 chicken
XP_004004127 263 RTLLGVLGIEATLESLI 279
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